Reactome | PDK isozymes phosphorylate PDHC subunit E1

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PDK isozymes phosphorylate PDHC subunit E1 Show undefined attributes

authored	[InstanceEdit:204185] Gopinathrao, G, 2007-11-26 20:29:38
catalystActivity	[CatalystActivity:203942] pyruvate dehydrogenase (acetyl-transferring) kinase activity of PDK isozyme dimers [mitochondrial matrix]
catalystActivityReference	[CatalystActivityReference:9643855] pyruvate dehydrogenase (acetyl-transferring) kinase activity of PDK isoforms [mitochondrial matrix] Regulation of pyruvate dehydrogenase activity through phosphorylation at multiple sites
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:203945] Gopinathrao, G, 2007-11-19 17:27:54
crossReference	[DatabaseIdentifier:9861895] RHEA:23053
dbId	203946
displayName	PDK isozymes phosphorylate PDHC subunit E1
edited	[InstanceEdit:203945] Gopinathrao, G, 2007-11-19 17:27:54
eventOf	[Pathway:R-HSA-204174] Regulation of pyruvate dehydrogenase (PDH) complex - Homo sapiens [Pathway:R-HSA-5362517] Signaling by Retinoic Acid - Homo sapiens
followingEvent	[Reaction:R-HSA-204169] PDP1,2 dephosphorylate p-lipo-PDH - Homo sapiens
input	2 × [SimpleEntity:R-ALL-113593] ATP [mitochondrial matrix] [Complex:R-HSA-70070] PDH complex [mitochondrial matrix]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:204153] Evidence for existence of tissue-specific regulation of the mammalian pyruvate dehydrogenase complex [LiteratureReference:204164] Diversity of the pyruvate dehydrogenase kinase gene family in humans [LiteratureReference:450877] Regulation of pyruvate dehydrogenase activity through phosphorylation at multiple sites [LiteratureReference:204152] Site specificity of four pyruvate dehydrogenase kinase isoenzymes toward the three phosphorylation sites of human pyruvate dehydrogenase [LiteratureReference:450881] Cloning and characterization of PDK4 on 7q21.3 encoding a fourth pyruvate dehydrogenase kinase isoenzyme in human [LiteratureReference:9861917] Pyruvate dehydrogenase kinases (PDKs): an overview toward clinical applications [LiteratureReference:9861883] Orchestration of Mitochondrial Function and Remodeling by Post-Translational Modifications Provide Insight into Mechanisms of Viral Infection
maxDepth	1
modified	[InstanceEdit:11051501] Weiser, Joel, 2026-03-16
name	PDK isozymes phosphorylate PDHC subunit E1 PDK-catalyzed phosphorylation (inactivation) of PDC E1 alpha subunit Inactivation of PDC by phosphorylation of PDC E1 alpha component
negativePrecedingEvent	[NegativePrecedingEvent:9908916] Futile Cycle: DLD dimer dehydrogenates dihydrolipoyl
orthologousEvent	[Reaction:R-DRE-203946] PDK isozymes phosphorylate PDHC subunit E1 - Danio rerio [Reaction:R-SSC-203946] PDK isozymes phosphorylate PDHC subunit E1 - Sus scrofa [Reaction:R-RNO-203946] PDK isozymes phosphorylate PDHC subunit E1 - Rattus norvegicus [Reaction:R-CFA-203946] PDK isozymes phosphorylate PDHC subunit E1 - Canis familiaris [Reaction:R-BTA-203946] PDK isozymes phosphorylate PDHC subunit E1 - Bos taurus [Reaction:R-DME-203946] PDK isozymes phosphorylate PDHC subunit E1 - Drosophila melanogaster [Reaction:R-CEL-203946] PDK isozymes phosphorylate PDHC subunit E1 - Caenorhabditis elegans [Reaction:R-XTR-203946] PDK isozymes phosphorylate PDHC subunit E1 - Xenopus tropicalis [Reaction:R-GGA-203946] PDK isozymes phosphorylate PDHC subunit E1 - Gallus gallus [Reaction:R-MMU-203946] PDK isozymes phosphorylate PDHC subunit E1 - Mus musculus [Reaction:R-SPO-203946] PDK isozymes phosphorylate PDHC subunit E1 - Schizosaccharomyces pombe
output	2 × [SimpleEntity:R-ALL-113581] ADP [mitochondrial matrix] [SimpleEntity:R-ALL-113529] H+ [mitochondrial matrix] [Complex:R-HSA-210342] p-lipo-PDH [mitochondrial matrix]
precedingEvent	[Reaction:R-HSA-204169] PDP1,2 dephosphorylate p-lipo-PDH - Homo sapiens [Reaction:R-HSA-9861667] DLAT trimer transfers acetyl to CoA - Homo sapiens
previousReviewStatus	[ReviewStatus:9821384] two stars
regulatedBy	[PositiveRegulation:R-HSA-210332] Positive regulation by 'Ac-CoA [mitochondrial matrix]' [NegativeRegulation:R-HSA-210344] Negative regulation by 'PYR [mitochondrial matrix]' [PositiveRegulation:R-HSA-210348] Positive regulation by 'NADH [mitochondrial matrix]' [NegativeRegulation:R-HSA-9011392] Negative regulation by 'DCA:PDK2 [mitochondrial matrix]'
releaseDate	2008-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:210329] D'Eustachio, P, 2008-01-11 20:49:08 [InstanceEdit:9034401] James, Margaret, 2018-01-05 [InstanceEdit:9862191] Hill, David P, 2024-02-23
revised	[InstanceEdit:450856] D'Eustachio, P, 2009-12-18 [InstanceEdit:5423020] Jassal, Bijay, 2014-05-08
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-203946
summation	[Summation:204167] The mitochondrial pyruvate dehydrogenase (PDH) complex (lipo... [Summation:9026978] In the nucleus, cellular retinoic acid-binding protein 1 or ...
updateTrackers	[UpdateTracker:9791061] Update Tracker - [Reaction:203946] PDK isoforms phosphorylate lipo-PDH - v32:[addLiteratureReference, modifyText] [UpdateTracker:9780549] Update Tracker - [Reaction:203946] PDK isoforms phosphorylate lipo-PDH - v62:[addLiteratureReference, addRegulator, modifyText] [UpdateTracker:9775953] Update Tracker - [Reaction:203946] PDK isoforms phosphorylate lipo-PDH - v78:[addSummation, modifyText] [UpdateTracker:9864088] Update Tracker - [Reaction:203946] PDK isozymes phosphorylate PDHC subunit E1 - v88:[addLiteratureReference, addOutput, modifyText, removeRegulator] [UpdateTracker:9785557] Update Tracker - [Reaction:203946] PDK isoforms phosphorylate lipo-PDH - v51:[add_removeRegulator] [UpdateTracker:9780170] Update Tracker - [Reaction:203946] PDK isoforms phosphorylate lipo-PDH - v63:[modifyText, removeLiteratureReference] [UpdateTracker:9786626] Update Tracker - [Reaction:203946] PDK isoforms phosphorylate lipo-PDH - v49:[addLiteratureReference, addRegulator, modifyText]

Referrals

(precedingEvent)	[Reaction:R-HSA-204169] PDP1,2 dephosphorylate p-lipo-PDH
(hasEvent)	[Pathway:R-HSA-5362517] Signaling by Retinoic Acid [Pathway:R-HSA-204174] Regulation of pyruvate dehydrogenase (PDH) complex
(updatedInstance)	[UpdateTracker:9791061] Update Tracker - [Reaction:203946] PDK isoforms phosphorylate lipo-PDH - v32:[addLiteratureReference, modifyText] [UpdateTracker:9780549] Update Tracker - [Reaction:203946] PDK isoforms phosphorylate lipo-PDH - v62:[addLiteratureReference, addRegulator, modifyText] [UpdateTracker:9775953] Update Tracker - [Reaction:203946] PDK isoforms phosphorylate lipo-PDH - v78:[addSummation, modifyText] [UpdateTracker:9864088] Update Tracker - [Reaction:203946] PDK isozymes phosphorylate PDHC subunit E1 - v88:[addLiteratureReference, addOutput, modifyText, removeRegulator] [UpdateTracker:9785557] Update Tracker - [Reaction:203946] PDK isoforms phosphorylate lipo-PDH - v51:[add_removeRegulator] [UpdateTracker:9780170] Update Tracker - [Reaction:203946] PDK isoforms phosphorylate lipo-PDH - v63:[modifyText, removeLiteratureReference] [UpdateTracker:9786626] Update Tracker - [Reaction:203946] PDK isoforms phosphorylate lipo-PDH - v49:[addLiteratureReference, addRegulator, modifyText]

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