Reactome | Regulation of pyruvate dehydrogenase (PDH) complex

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Regulation of pyruvate dehydrogenase (PDH) complex Show undefined attributes

compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10444172
displayName	Regulation of pyruvate dehydrogenase (PDH) complex
eventOf	[Pathway:R-BTA-9861718] Regulation of pyruvate metabolism - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:210317] regulation of pyruvate decarboxylation to acetyl-CoA
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-BTA-9011595] GSTZ1 dimer dehalogenates DCA - Bos taurus [Reaction:R-BTA-9011543] DCA binds PDK2 - Bos taurus [Reaction:R-BTA-203946] PDK isozymes phosphorylate PDHC subunit E1 - Bos taurus [Reaction:R-BTA-204169] PDP1,2 dephosphorylate p-lipo-PDH - Bos taurus [Reaction:R-BTA-9861626] SIRT4 cleaves lipoyl from DLAT - Bos taurus
inferredFrom	[Pathway:R-HSA-204174] Regulation of pyruvate dehydrogenase (PDH) complex - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Regulation of pyruvate dehydrogenase (PDH) complex
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48898] Bos taurus
stId	R-BTA-204174
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-9861718] Regulation of pyruvate metabolism
(inferredTo)	[Pathway:R-HSA-204174] Regulation of pyruvate dehydrogenase (PDH) complex

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