Reactome | Signaling by Hippo

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Signaling by Hippo Show undefined attributes

compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10445182
displayName	Signaling by Hippo
eventOf	[TopLevelPathway:R-BTA-162582] Signal Transduction - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:937682] hippo signaling
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-BTA-2028591] Phosphorylation of STK3 (MST2) and SAV1 by STK3 - Bos taurus [Reaction:R-BTA-2028284] Phosphorylation of STK4 (MST1) and SAV1 by STK4 - Bos taurus [Reaction:R-BTA-2028697] Cleavage of p-STK3 (p-MST2) by caspase 3 - Bos taurus [Reaction:R-BTA-2028692] Cleavage of p-STK4 (p-MST1) by caspase 3 - Bos taurus [Reaction:R-BTA-2038398] KIBRA (WWC1) binds LATS proteins - Bos taurus [Reaction:R-BTA-2059926] NPHP4 protein binds LATS proteins - Bos taurus [Reaction:R-BTA-2028589] Phosphorylation of LATS1 and 2 by p-STK3 (p-MST2) - Bos taurus [Reaction:R-BTA-2028673] Phosphorylation of LATS1 and 2 by p-STK3 (MST2)/N - Bos taurus [Reaction:R-BTA-2028555] Phosphorylation of LATS1 and 2 by p-STK4 (p-MST1) - Bos taurus [Reaction:R-BTA-2028679] Phosphorylation of LATS1 and 2 by p-STK4(MST1)/N - Bos taurus [Reaction:R-BTA-2028635] Phosphorylation of MOB1A and B by p-STK3 (p-MST2) - Bos taurus [Reaction:R-BTA-2028675] Phosphorylation of MOB1A and B by p-STK3(MST2)/N - Bos taurus [Reaction:R-BTA-2028629] Phosphorylation of MOB1A and B by p-STK4 (p-MST1) - Bos taurus [Reaction:R-BTA-2028670] Phosphorylation of MOB1A and B by p-STK4(MST1)/N - Bos taurus [Reaction:R-BTA-2028626] Phosphorylated MOB1A proteins associate with LATS proteins - Bos taurus [Reaction:R-BTA-2032770] Translocation of YAP1 to the nucleus - Bos taurus [Reaction:R-BTA-2064421] YAP1 binds ZO-2 (TJP2) - Bos taurus [Reaction:R-BTA-2064406] Translocation of YAP1:ZO-2 (TJP2) to the nucleus - Bos taurus [Reaction:R-BTA-2028724] AMOT proteins bind YAP1 - Bos taurus [Reaction:R-BTA-2028598] Phosphorylation of YAP by LATS1 - Bos taurus [Reaction:R-BTA-2028583] Phosphorylation of YAP by LATS2 - Bos taurus [Reaction:R-BTA-2028644] YWHAB (14-3-3 beta/alpha) dimer binds phosphorylated YAP1 - Bos taurus [Reaction:R-BTA-2032768] Translocation of WWTR1 (TAZ) to the nucleus - Bos taurus [Reaction:R-BTA-2064418] WWTR1 (TAZ) binds ZO-2 (TJP2) - Bos taurus [Reaction:R-BTA-2028735] AMOT proteins bind WWTR1 (TAZ) - Bos taurus [Reaction:R-BTA-2060328] Phosphorylation of WWTR1 (TAZ) by LATS1 - Bos taurus [Reaction:R-BTA-2028661] Phosphorylation of WWTR1 (TAZ) by LATS2 - Bos taurus [Reaction:R-BTA-2066299] DVL2 binds phosphorylated WWTR1 (TAZ) - Bos taurus [Reaction:R-BTA-2028651] YWHAE (14-3-3 epsilon) dimer binds phosphorylated WWTR1 (TAZ) - Bos taurus
inferredFrom	[Pathway:R-HSA-2028269] Signaling by Hippo - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Signaling by Hippo Hippo signaling cascade
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48898] Bos taurus
stId	R-BTA-2028269
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[TopLevelPathway:R-BTA-162582] Signal Transduction
(hasEncapsulatedEvent)	[Pathway:R-BTA-1236394] Signaling by ERBB4 [Pathway:R-BTA-2032785] YAP1- and WWTR1 (TAZ)-stimulated gene expression
(inferredTo)	[Pathway:R-HSA-2028269] Signaling by Hippo

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