Reactome | Phosphorylation of WWTR1 (TAZ) by LATS2

Schema > Reaction > Entries

Phosphorylation of WWTR1 (TAZ) by LATS2 Show undefined attributes

catalystActivity	[CatalystActivity:10384991] protein serine/threonine kinase activity of p-LATS2:p-MOB1 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10385065
displayName	Phosphorylation of WWTR1 (TAZ) by LATS2
eventOf	[Pathway:R-BTA-2028269] Signaling by Hippo - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-BTA-2028651] YWHAE (14-3-3 epsilon) dimer binds phosphorylated WWTR1 (TAZ) - Bos taurus [Reaction:R-BTA-2066299] DVL2 binds phosphorylated WWTR1 (TAZ) - Bos taurus
inferredFrom	[Reaction:R-HSA-2028661] Phosphorylation of WWTR1 (TAZ) by LATS2 - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [EntityWithAccessionedSequence:R-BTA-1629773] WWTR1 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Phosphorylation of WWTR1 (TAZ) by LATS2
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [EntityWithAccessionedSequence:R-BTA-2028665] phospho-WWTR1 [cytosol]
precedingEvent	[Reaction:R-BTA-2028589] Phosphorylation of LATS1 and 2 by p-STK3 (p-MST2) - Bos taurus [Reaction:R-BTA-2028555] Phosphorylation of LATS1 and 2 by p-STK4 (p-MST1) - Bos taurus
regulatedBy	[PositiveRegulation:10385008] Positive regulation by 'AMOT proteins [cytosol]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-2028661
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-2028269] Signaling by Hippo
(precedingEvent)	[Reaction:R-BTA-2028651] YWHAE (14-3-3 epsilon) dimer binds phosphorylated WWTR1 (TAZ) [Reaction:R-BTA-2066299] DVL2 binds phosphorylated WWTR1 (TAZ)
(inferredTo)	[Reaction:R-HSA-2028661] Phosphorylation of WWTR1 (TAZ) by LATS2