Reactome | type I KIT binding TKIs [cytosol]

Schema > DefinedSet > Entries

compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-HSA-9671495] type I sensitive KIT mutants:type I TKIs [plasma membrane] - Homo sapiens [Complex:R-XTR-9669711] KIT:sSCF dimer:KIT:type I KIT binding TKIs: [plasma membrane] - Xenopus tropicalis
consumedByEvent	[Reaction:R-HSA-9669898] KIT mutants bind type I TKIs - Homo sapiens [Reaction:R-GGA-9669893] KIT binds type I TKIs - Gallus gallus [Reaction:R-XTR-9669893] KIT binds type I TKIs - Xenopus tropicalis [Reaction:R-DRE-9669893] KIT binds type I TKIs - Danio rerio [Reaction:R-SSC-9669893] KIT binds type I TKIs - Sus scrofa [Reaction:R-BTA-9669893] KIT binds type I TKIs - Bos taurus [Reaction:R-CFA-9669893] KIT binds type I TKIs - Canis familiaris [Reaction:R-RNO-9669893] KIT binds type I TKIs - Rattus norvegicus [Reaction:R-MMU-9669893] KIT binds type I TKIs - Mus musculus [Reaction:R-HSA-9669893] KIT binds type I TKIs - Homo sapiens
created	[InstanceEdit:9669712] Rothfels, Karen, 2019-12-03
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	9669710
disease	[Disease:1500689] cancer
displayName	type I KIT binding TKIs [cytosol]
hasMember	[ChemicalDrug:R-ALL-1839035] dovitinib [cytosol] [ChemicalDrug:R-ALL-2038921] midostaurin [cytosol] [ChemicalDrug:R-ALL-9671491] avapritinib [cytosol]
inDisease	true
maxDepth	2
modified	[InstanceEdit:9671501] Rothfels, Karen, 2019-12-19
name	type I KIT binding TKIs
schemaClass	DefinedSet
stId	R-ALL-9669710

(hasComponent)	[Complex:R-HSA-9671495] type I sensitive KIT mutants:type I TKIs [plasma membrane] [Complex:R-XTR-9669711] KIT:sSCF dimer:KIT:type I KIT binding TKIs: [plasma membrane] [Complex:R-CFA-9669711] KIT:sSCF dimer:KIT:type I KIT binding TKIs: [plasma membrane] [Complex:R-GGA-9669711] KIT:sSCF dimer:KIT:type I KIT binding TKIs: [plasma membrane] [Complex:R-SSC-9669711] KIT:sSCF dimer:KIT:type I KIT binding TKIs: [plasma membrane] [Complex:R-RNO-9669711] KIT:sSCF dimer:KIT:type I KIT binding TKIs: [plasma membrane] [Complex:R-DRE-9669711] KIT:sSCF dimer:KIT:type I KIT binding TKIs: [plasma membrane] [Complex:R-MMU-9669711] KIT:sSCF dimer:KIT:type I KIT binding TKIs: [plasma membrane] [Complex:R-HSA-9669711] KIT:sSCF dimer:KIT:type I KIT binding TKIs: [plasma membrane] [Complex:R-BTA-9669711] KIT:sSCF dimer:KIT:type I KIT binding TKIs: [plasma membrane]
(input)	[Reaction:R-HSA-9669898] KIT mutants bind type I TKIs [Reaction:R-GGA-9669893] KIT binds type I TKIs [Reaction:R-XTR-9669893] KIT binds type I TKIs [Reaction:R-DRE-9669893] KIT binds type I TKIs [Reaction:R-SSC-9669893] KIT binds type I TKIs [Reaction:R-BTA-9669893] KIT binds type I TKIs [Reaction:R-CFA-9669893] KIT binds type I TKIs [Reaction:R-RNO-9669893] KIT binds type I TKIs [Reaction:R-MMU-9669893] KIT binds type I TKIs [Reaction:R-HSA-9669893] KIT binds type I TKIs
(activeUnit)	[NegativeRegulation:9669884] Negative regulation by 'KIT:sSCF dimer:KIT:type I KIT binding TKIs: [plasma membrane]'

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