Reactome | dovitinib [cytosol]

Schema > ChemicalDrug > Entries

compartment	[Compartment:70101] cytosol
created	[InstanceEdit:1839034] Rothfels, K, 2011-10-27
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992 [DatabaseIdentifier:9628078] PubChem Compound:9886808
dbId	1839035
disease	[Disease:1500689] cancer
displayName	dovitinib [cytosol]
inDisease	true
literatureReference	[LiteratureReference:2023313] In vivo target modulation and biological activity of CHIR-258, a multitargeted growth factor receptor kinase inhibitor, in colon cancer models [LiteratureReference:2023310] A phase I pharmacokinetic and pharmacodynamic study of TKI258, an oral, multitargeted receptor tyrosine kinase inhibitor in patients with advanced solid tumors
maxDepth	1
memberOf	[DefinedSet:R-ALL-2023441] Tyrosine kinase inhibitors of overexpressed FGFR1 [cytosol] [DefinedSet:R-ALL-2077416] Tyrosine kinase inhibitors of FGFR3 mutants [cytosol]
modified	[InstanceEdit:9669664] Rothfels, Karen, 2019-12-03
name	dovitinib TKI258
referenceEntity	[ReferenceTherapeutic:iuphar.ligand:5962] dovitinib [Guide to Pharmacology:5962]
schemaClass	ChemicalDrug
stId	R-ALL-1839035
summation	[Summation:2023211] A Novartis tyrosine kinase inhibitor with activity against m...
updateTrackers	[UpdateTracker:9901026] Update Tracker - [ChemicalDrug:1839035] dovitinib [cytosol] - v72:[modifyName]

(updatedInstance)	[UpdateTracker:9901026] Update Tracker - [ChemicalDrug:1839035] dovitinib [cytosol] - v72:[modifyName]
(hasMember)	[DefinedSet:R-ALL-2077416] Tyrosine kinase inhibitors of FGFR3 mutants [cytosol] [DefinedSet:R-ALL-2023441] Tyrosine kinase inhibitors of overexpressed FGFR1 [cytosol] [DefinedSet:R-ALL-2045079] Tyrosine kinase inhibitors of FGFR1 fusion mutants [cytosol] [DefinedSet:R-ALL-9669710] type I KIT binding TKIs [cytosol]