Reactome | KIT binds type I TKIs

Schema > Reaction > Entries

category	binding
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10546839
displayName	KIT binds type I TKIs
eventOf	[Pathway:R-SSC-1433557] Signaling by SCF-KIT - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-9669893] KIT binds type I TKIs - Homo sapiens
input	[Complex:R-SSC-205208] KIT:sSCF dimer:KIT [plasma membrane] [DefinedSet:R-ALL-9669710] type I KIT binding TKIs [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	KIT binds type I TKIs
output	[Complex:R-SSC-9669711] KIT:sSCF dimer:KIT:type I KIT binding TKIs: [plasma membrane]
precedingEvent	[Reaction:R-SSC-205231] Dimerization of KIT upon SCF binding - Sus scrofa
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-9669893
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-SSC-1433557] Signaling by SCF-KIT
(inferredTo)	[Reaction:R-HSA-9669893] KIT binds type I TKIs

Cite Us!