Reactome | dual mechanism MAP2K1/2 inhibitors [cytosol]

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dual mechanism MAP2K1/2 inhibitors [cytosol] Show undefined attributes

compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-SSC-9657583] activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] - Sus scrofa
consumedByEvent	[Reaction:R-DDI-9657599] Dual mechanism MAP2K inhibitors bind MAP2Ks - Dictyostelium discoideum [Reaction:R-CEL-9657599] Dual mechanism MAP2K inhibitors bind MAP2Ks - Caenorhabditis elegans [Reaction:R-DME-9657599] Dual mechanism MAP2K inhibitors bind MAP2Ks - Drosophila melanogaster [Reaction:R-GGA-9657599] Dual mechanism MAP2K inhibitors bind MAP2Ks - Gallus gallus [Reaction:R-DRE-9657599] Dual mechanism MAP2K inhibitors bind MAP2Ks - Danio rerio [Reaction:R-SSC-9657599] Dual mechanism MAP2K inhibitors bind MAP2Ks - Sus scrofa [Reaction:R-BTA-9657599] Dual mechanism MAP2K inhibitors bind MAP2Ks - Bos taurus [Reaction:R-CFA-9657599] Dual mechanism MAP2K inhibitors bind MAP2Ks - Canis familiaris [Reaction:R-RNO-9657599] Dual mechanism MAP2K inhibitors bind MAP2Ks - Rattus norvegicus [Reaction:R-MMU-9657599] Dual mechanism MAP2K inhibitors bind MAP2Ks - Mus musculus [Reaction:R-HSA-9657599] Dual mechanism MAP2K inhibitors bind MAP2Ks - Homo sapiens
created	[InstanceEdit:9657568] Rothfels, Karen, 2019-08-08
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	9657567
disease	[Disease:1500689] cancer
displayName	dual mechanism MAP2K1/2 inhibitors [cytosol]
hasCandidate	[ChemicalDrug:R-ALL-9657560] GDC-0623 [cytosol] [ChemicalDrug:R-ALL-9657549] RO 5126766 [cytosol]
hasMember	[ChemicalDrug:R-ALL-9653120] trametinib [cytosol]
inDisease	true
maxDepth	2
name	dual mechanism MAP2K1/2 inhibitors
schemaClass	CandidateSet
stId	R-ALL-9657567

Referrals

(input)	[Reaction:R-DDI-9657599] Dual mechanism MAP2K inhibitors bind MAP2Ks [Reaction:R-CEL-9657599] Dual mechanism MAP2K inhibitors bind MAP2Ks [Reaction:R-DME-9657599] Dual mechanism MAP2K inhibitors bind MAP2Ks [Reaction:R-GGA-9657599] Dual mechanism MAP2K inhibitors bind MAP2Ks [Reaction:R-DRE-9657599] Dual mechanism MAP2K inhibitors bind MAP2Ks [Reaction:R-SSC-9657599] Dual mechanism MAP2K inhibitors bind MAP2Ks [Reaction:R-BTA-9657599] Dual mechanism MAP2K inhibitors bind MAP2Ks [Reaction:R-CFA-9657599] Dual mechanism MAP2K inhibitors bind MAP2Ks [Reaction:R-RNO-9657599] Dual mechanism MAP2K inhibitors bind MAP2Ks [Reaction:R-MMU-9657599] Dual mechanism MAP2K inhibitors bind MAP2Ks [Reaction:R-HSA-9657599] Dual mechanism MAP2K inhibitors bind MAP2Ks
(hasComponent)	[Complex:R-SSC-9657583] activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] [Complex:R-DDI-9657583] activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] [Complex:R-DRE-9657583] activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] [Complex:R-RNO-9657583] activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] [Complex:R-BTA-9657583] activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] [Complex:R-CFA-9657583] activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] [Complex:R-DME-9657583] activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] [Complex:R-CEL-9657583] activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] [Complex:R-GGA-9657583] activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] [Complex:R-MMU-9657583] activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] [Complex:R-HSA-9657583] activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane]
(activeUnit)	[NegativeRegulation:9657612] Negative regulation by 'activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane]'

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