Reactome | trametinib [cytosol]

Schema > ChemicalDrug > Entries

compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9653119] Rothfels, Karen, 2019-07-09
crossReference	[DatabaseIdentifier:12020751] Mondo:0005105 [DatabaseIdentifier:9653077] ChEBI:75998 [DatabaseIdentifier:9653076] ChEBI:75991
dbId	9653120
disease	[Disease:1614289] melanoma
displayName	trametinib [cytosol]
inDisease	true
literatureReference	[LiteratureReference:9653011] A phase 1b study of trametinib, an oral Mitogen-activated protein kinase kinase (MEK) inhibitor, in combination with gemcitabine in advanced solid tumours [LiteratureReference:9652847] Trametinib: A Targeted Therapy in Metastatic Melanoma
maxDepth	1
memberOf	[CandidateSet:R-ALL-9657567] dual mechanism MAP2K1/2 inhibitors [cytosol]
name	trametinib trametinib dimethylsulfoxide
referenceEntity	[ReferenceTherapeutic:iuphar.ligand:6495] trametinib [Guide to Pharmacology:6495]
schemaClass	ChemicalDrug
stId	R-ALL-9653120

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