Reactome | Dual mechanism MAP2K inhibitors bind MAP2Ks

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Dual mechanism MAP2K inhibitors bind MAP2Ks Show undefined attributes

category	binding
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10089314
displayName	Dual mechanism MAP2K inhibitors bind MAP2Ks
eventOf	[Pathway:R-MMU-5674135] MAP2K and MAPK activation - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-9657599] Dual mechanism MAP2K inhibitors bind MAP2Ks - Homo sapiens
input	[Complex:R-MMU-5672720] activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] [CandidateSet:R-ALL-9657567] dual mechanism MAP2K1/2 inhibitors [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Dual mechanism MAP2K inhibitors bind MAP2Ks
output	[Complex:R-MMU-9657583] activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane]
precedingEvent	[Reaction:R-MMU-5672972] MAP2Ks and MAPKs bind to the activated RAF complex - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-9657599
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-5674135] MAP2K and MAPK activation
(inferredTo)	[Reaction:R-HSA-9657599] Dual mechanism MAP2K inhibitors bind MAP2Ks

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