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dual mechanism MAP2K1/2 inhibitors [cytosol]
Stable Identifier
R-ALL-9657567
Type
Set [CandidateSet]
Compartment
cytosol
Locations in the PathwayBrowser
for Species:
Homo sapiens
Bos taurus
Caenorhabditis elegans
Canis familiaris
Danio rerio
Dictyostelium discoideum
Drosophila melanogaster
Gallus gallus
Mus musculus
Rattus norvegicus
Sus scrofa
Xenopus tropicalis
Expand all
Signal Transduction (Bos taurus)
MAPK family signaling cascades (Bos taurus)
MAPK1/MAPK3 signaling (Bos taurus)
RAF/MAP kinase cascade (Bos taurus)
MAP2K and MAPK activation (Bos taurus)
Dual mechanism MAP2K inhibitors bind MAP2Ks (Bos taurus)
dual mechanism MAP2K1/2 inhibitors [cytosol]
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Bos taurus)
dual mechanism MAP2K1/2 inhibitors [cytosol]
MAP2Ks phosphorylate MAPKs (Bos taurus)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Bos taurus)
dual mechanism MAP2K1/2 inhibitors [cytosol]
RAF phosphorylates MAP2K dimer (Bos taurus)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Bos taurus)
dual mechanism MAP2K1/2 inhibitors [cytosol]
Signal Transduction (Caenorhabditis elegans)
MAPK family signaling cascades (Caenorhabditis elegans)
MAPK1/MAPK3 signaling (Caenorhabditis elegans)
RAF/MAP kinase cascade (Caenorhabditis elegans)
MAP2K and MAPK activation (Caenorhabditis elegans)
Dual mechanism MAP2K inhibitors bind MAP2Ks (Caenorhabditis elegans)
dual mechanism MAP2K1/2 inhibitors [cytosol]
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Caenorhabditis elegans)
dual mechanism MAP2K1/2 inhibitors [cytosol]
MAP2Ks phosphorylate MAPKs (Caenorhabditis elegans)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Caenorhabditis elegans)
dual mechanism MAP2K1/2 inhibitors [cytosol]
RAF phosphorylates MAP2K dimer (Caenorhabditis elegans)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Caenorhabditis elegans)
dual mechanism MAP2K1/2 inhibitors [cytosol]
Signal Transduction (Canis familiaris)
MAPK family signaling cascades (Canis familiaris)
MAPK1/MAPK3 signaling (Canis familiaris)
RAF/MAP kinase cascade (Canis familiaris)
MAP2K and MAPK activation (Canis familiaris)
Dual mechanism MAP2K inhibitors bind MAP2Ks (Canis familiaris)
dual mechanism MAP2K1/2 inhibitors [cytosol]
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Canis familiaris)
dual mechanism MAP2K1/2 inhibitors [cytosol]
MAP2Ks phosphorylate MAPKs (Canis familiaris)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Canis familiaris)
dual mechanism MAP2K1/2 inhibitors [cytosol]
RAF phosphorylates MAP2K dimer (Canis familiaris)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Canis familiaris)
dual mechanism MAP2K1/2 inhibitors [cytosol]
Signal Transduction (Danio rerio)
MAPK family signaling cascades (Danio rerio)
MAPK1/MAPK3 signaling (Danio rerio)
RAF/MAP kinase cascade (Danio rerio)
MAP2K and MAPK activation (Danio rerio)
Dual mechanism MAP2K inhibitors bind MAP2Ks (Danio rerio)
dual mechanism MAP2K1/2 inhibitors [cytosol]
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Danio rerio)
dual mechanism MAP2K1/2 inhibitors [cytosol]
MAP2Ks phosphorylate MAPKs (Danio rerio)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Danio rerio)
dual mechanism MAP2K1/2 inhibitors [cytosol]
RAF phosphorylates MAP2K dimer (Danio rerio)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Danio rerio)
dual mechanism MAP2K1/2 inhibitors [cytosol]
Signal Transduction (Dictyostelium discoideum)
MAPK family signaling cascades (Dictyostelium discoideum)
MAPK1/MAPK3 signaling (Dictyostelium discoideum)
RAF/MAP kinase cascade (Dictyostelium discoideum)
MAP2K and MAPK activation (Dictyostelium discoideum)
Dual mechanism MAP2K inhibitors bind MAP2Ks (Dictyostelium discoideum)
dual mechanism MAP2K1/2 inhibitors [cytosol]
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Dictyostelium discoideum)
dual mechanism MAP2K1/2 inhibitors [cytosol]
MAP2Ks phosphorylate MAPKs (Dictyostelium discoideum)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Dictyostelium discoideum)
dual mechanism MAP2K1/2 inhibitors [cytosol]
RAF phosphorylates MAP2K dimer (Dictyostelium discoideum)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Dictyostelium discoideum)
dual mechanism MAP2K1/2 inhibitors [cytosol]
Signal Transduction (Drosophila melanogaster)
MAPK family signaling cascades (Drosophila melanogaster)
MAPK1/MAPK3 signaling (Drosophila melanogaster)
RAF/MAP kinase cascade (Drosophila melanogaster)
MAP2K and MAPK activation (Drosophila melanogaster)
Dual mechanism MAP2K inhibitors bind MAP2Ks (Drosophila melanogaster)
dual mechanism MAP2K1/2 inhibitors [cytosol]
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Drosophila melanogaster)
dual mechanism MAP2K1/2 inhibitors [cytosol]
MAP2Ks phosphorylate MAPKs (Drosophila melanogaster)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Drosophila melanogaster)
dual mechanism MAP2K1/2 inhibitors [cytosol]
RAF phosphorylates MAP2K dimer (Drosophila melanogaster)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Drosophila melanogaster)
dual mechanism MAP2K1/2 inhibitors [cytosol]
Signal Transduction (Gallus gallus)
MAPK family signaling cascades (Gallus gallus)
MAPK1/MAPK3 signaling (Gallus gallus)
RAF/MAP kinase cascade (Gallus gallus)
MAP2K and MAPK activation (Gallus gallus)
Dual mechanism MAP2K inhibitors bind MAP2Ks (Gallus gallus)
dual mechanism MAP2K1/2 inhibitors [cytosol]
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Gallus gallus)
dual mechanism MAP2K1/2 inhibitors [cytosol]
MAP2Ks phosphorylate MAPKs (Gallus gallus)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Gallus gallus)
dual mechanism MAP2K1/2 inhibitors [cytosol]
RAF phosphorylates MAP2K dimer (Gallus gallus)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Gallus gallus)
dual mechanism MAP2K1/2 inhibitors [cytosol]
Signal Transduction (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK1/MAPK3 signaling (Homo sapiens)
RAF/MAP kinase cascade (Homo sapiens)
MAP2K and MAPK activation (Homo sapiens)
Dual mechanism MAP2K inhibitors bind MAP2Ks (Homo sapiens)
dual mechanism MAP2K1/2 inhibitors [cytosol]
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
dual mechanism MAP2K1/2 inhibitors [cytosol]
MAP2Ks phosphorylate MAPKs (Homo sapiens)
dual mechanism MAP2K1/2 inhibitors [cytosol]
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
dual mechanism MAP2K1/2 inhibitors [cytosol]
RAF phosphorylates MAP2K dimer (Homo sapiens)
dual mechanism MAP2K1/2 inhibitors [cytosol]
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
dual mechanism MAP2K1/2 inhibitors [cytosol]
Signal Transduction (Mus musculus)
MAPK family signaling cascades (Mus musculus)
MAPK1/MAPK3 signaling (Mus musculus)
RAF/MAP kinase cascade (Mus musculus)
MAP2K and MAPK activation (Mus musculus)
Dual mechanism MAP2K inhibitors bind MAP2Ks (Mus musculus)
dual mechanism MAP2K1/2 inhibitors [cytosol]
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Mus musculus)
dual mechanism MAP2K1/2 inhibitors [cytosol]
MAP2Ks phosphorylate MAPKs (Mus musculus)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Mus musculus)
dual mechanism MAP2K1/2 inhibitors [cytosol]
RAF phosphorylates MAP2K dimer (Mus musculus)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Mus musculus)
dual mechanism MAP2K1/2 inhibitors [cytosol]
Signal Transduction (Rattus norvegicus)
MAPK family signaling cascades (Rattus norvegicus)
MAPK1/MAPK3 signaling (Rattus norvegicus)
RAF/MAP kinase cascade (Rattus norvegicus)
MAP2K and MAPK activation (Rattus norvegicus)
Dual mechanism MAP2K inhibitors bind MAP2Ks (Rattus norvegicus)
dual mechanism MAP2K1/2 inhibitors [cytosol]
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Rattus norvegicus)
dual mechanism MAP2K1/2 inhibitors [cytosol]
MAP2Ks phosphorylate MAPKs (Rattus norvegicus)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Rattus norvegicus)
dual mechanism MAP2K1/2 inhibitors [cytosol]
RAF phosphorylates MAP2K dimer (Rattus norvegicus)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Rattus norvegicus)
dual mechanism MAP2K1/2 inhibitors [cytosol]
Signal Transduction (Sus scrofa)
MAPK family signaling cascades (Sus scrofa)
MAPK1/MAPK3 signaling (Sus scrofa)
RAF/MAP kinase cascade (Sus scrofa)
MAP2K and MAPK activation (Sus scrofa)
Dual mechanism MAP2K inhibitors bind MAP2Ks (Sus scrofa)
dual mechanism MAP2K1/2 inhibitors [cytosol]
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Sus scrofa)
dual mechanism MAP2K1/2 inhibitors [cytosol]
MAP2Ks phosphorylate MAPKs (Sus scrofa)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Sus scrofa)
dual mechanism MAP2K1/2 inhibitors [cytosol]
RAF phosphorylates MAP2K dimer (Sus scrofa)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Sus scrofa)
dual mechanism MAP2K1/2 inhibitors [cytosol]
Signal Transduction (Xenopus tropicalis)
MAPK family signaling cascades (Xenopus tropicalis)
MAPK1/MAPK3 signaling (Xenopus tropicalis)
RAF/MAP kinase cascade (Xenopus tropicalis)
MAP2K and MAPK activation (Xenopus tropicalis)
Dual mechanism MAP2K inhibitors bind MAP2Ks (Xenopus tropicalis)
dual mechanism MAP2K1/2 inhibitors [cytosol]
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Xenopus tropicalis)
dual mechanism MAP2K1/2 inhibitors [cytosol]
MAP2Ks phosphorylate MAPKs (Xenopus tropicalis)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Xenopus tropicalis)
dual mechanism MAP2K1/2 inhibitors [cytosol]
RAF phosphorylates MAP2K dimer (Xenopus tropicalis)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Xenopus tropicalis)
dual mechanism MAP2K1/2 inhibitors [cytosol]
Participants
members
trametinib [cytosol]
candidates
GDC-0623 [cytosol]
RO 5126766 [cytosol]
Participates
as an input of
Dual mechanism MAP2K inhibitors bind MAP2Ks (Dictyostelium discoideum)
Dual mechanism MAP2K inhibitors bind MAP2Ks (Caenorhabditis elegans)
Dual mechanism MAP2K inhibitors bind MAP2Ks (Drosophila melanogaster)
Dual mechanism MAP2K inhibitors bind MAP2Ks (Gallus gallus)
Dual mechanism MAP2K inhibitors bind MAP2Ks (Xenopus tropicalis)
Dual mechanism MAP2K inhibitors bind MAP2Ks (Danio rerio)
Dual mechanism MAP2K inhibitors bind MAP2Ks (Sus scrofa)
Dual mechanism MAP2K inhibitors bind MAP2Ks (Bos taurus)
Dual mechanism MAP2K inhibitors bind MAP2Ks (Canis familiaris)
Dual mechanism MAP2K inhibitors bind MAP2Ks (Rattus norvegicus)
Dual mechanism MAP2K inhibitors bind MAP2Ks (Mus musculus)
Dual mechanism MAP2K inhibitors bind MAP2Ks (Homo sapiens)
as a component of
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Caenorhabditis elegans)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Gallus gallus)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Bos taurus)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Drosophila melanogaster)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Danio rerio)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Mus musculus)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Canis familiaris)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Sus scrofa)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Dictyostelium discoideum)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Xenopus tropicalis)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Rattus norvegicus)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
Disease
Name
Identifier
Synonyms
cancer
DOID:162
malignant tumor, malignant neoplasm, primary cancer
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