Reactome | 2M3OPROA [mitochondrial matrix]

Schema > SimpleEntity > Entries

2M3OPROA [mitochondrial matrix] Show undefined attributes

compartment	[Compartment:5460] mitochondrial matrix
consumedByEvent	[Reaction:R-DDI-70893] methylmalonate semialdehyde + NAD+ + CoA + H2O => propionyl-CoA + HCO3- + NADH + H+ - Dictyostelium discoideum [Reaction:R-CEL-70893] methylmalonate semialdehyde + NAD+ + CoA + H2O => propionyl-CoA + HCO3- + NADH + H+ - Caenorhabditis elegans [Reaction:R-DME-70893] methylmalonate semialdehyde + NAD+ + CoA + H2O => propionyl-CoA + HCO3- + NADH + H+ - Drosophila melanogaster [Reaction:R-GGA-70893] methylmalonate semialdehyde + NAD+ + CoA + H2O => propionyl-CoA + HCO3- + NADH + H+ - Gallus gallus [Reaction:R-XTR-70893] methylmalonate semialdehyde + NAD+ + CoA + H2O => propionyl-CoA + HCO3- + NADH + H+ - Xenopus tropicalis [Reaction:R-DRE-70893] methylmalonate semialdehyde + NAD+ + CoA + H2O => propionyl-CoA + HCO3- + NADH + H+ - Danio rerio [Reaction:R-SSC-70893] methylmalonate semialdehyde + NAD+ + CoA + H2O => propionyl-CoA + HCO3- + NADH + H+ - Sus scrofa [Reaction:R-BTA-70893] methylmalonate semialdehyde + NAD+ + CoA + H2O => propionyl-CoA + HCO3- + NADH + H+ - Bos taurus [Reaction:R-CFA-70893] methylmalonate semialdehyde + NAD+ + CoA + H2O => propionyl-CoA + HCO3- + NADH + H+ - Canis familiaris [Reaction:R-RNO-70893] methylmalonate semialdehyde + NAD+ + CoA + H2O => propionyl-CoA + HCO3- + NADH + H+ - Rattus norvegicus [Reaction:R-MMU-70893] methylmalonate semialdehyde + NAD+ + CoA + H2O => propionyl-CoA + HCO3- + NADH + H+ - Mus musculus [Reaction:R-DDI-508473] methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+ - Dictyostelium discoideum [Reaction:R-CEL-508473] methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+ - Caenorhabditis elegans [Reaction:R-DME-508473] methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+ - Drosophila melanogaster [Reaction:R-GGA-508473] methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+ - Gallus gallus [Reaction:R-XTR-508473] methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+ - Xenopus tropicalis [Reaction:R-DRE-508473] methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+ - Danio rerio [Reaction:R-SSC-508473] methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+ - Sus scrofa [Reaction:R-BTA-508473] methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+ - Bos taurus [Reaction:R-CFA-508473] methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+ - Canis familiaris [Reaction:R-RNO-508473] methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+ - Rattus norvegicus [Reaction:R-MMU-508473] methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+ - Mus musculus [Reaction:R-HSA-508473] methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+ - Homo sapiens [Reaction:R-HSA-70893] methylmalonate semialdehyde + NAD+ + CoA + H2O => propionyl-CoA + HCO3- + NADH + H+ - Homo sapiens
crossReference	[DatabaseIdentifier:30005] COMPOUND:C00349
dbId	30004
displayName	2M3OPROA [mitochondrial matrix]
inDisease	false
maxDepth	1
modified	[InstanceEdit:9925948] D'Eustachio, Peter, 2024-10-28
name	2M3OPROA 2-Methyl-3-oxopropanoate 2-methyl-3-oxopropanoic acid 3-Oxo-2-methylpropanoate Methylmalonate semialdehyde
producedByEvent	[Reaction:R-RNO-909775] (R)-3-aminoisobutyric acid + pyruvate => 2-methyl-3-oxopropanoate + alanine - Rattus norvegicus [Reaction:R-DDI-70885] beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+ - Dictyostelium discoideum [Reaction:R-CEL-70885] beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+ - Caenorhabditis elegans [Reaction:R-DME-70885] beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+ - Drosophila melanogaster [Reaction:R-GGA-70885] beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+ - Gallus gallus [Reaction:R-XTR-70885] beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+ - Xenopus tropicalis [Reaction:R-DRE-70885] beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+ - Danio rerio [Reaction:R-SSC-70885] beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+ - Sus scrofa [Reaction:R-BTA-70885] beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+ - Bos taurus [Reaction:R-CFA-70885] beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+ - Canis familiaris [Reaction:R-RNO-70885] beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+ - Rattus norvegicus [Reaction:R-MMU-70885] beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+ - Mus musculus [Reaction:R-HSA-70885] beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+ - Homo sapiens
referenceEntity	[ReferenceMolecule:chebi:62413] (S)-methylmalonate semialdehyde [ChEBI:62413]
referenceType	ReferenceMolecule
schemaClass	SimpleEntity
stId	R-ALL-30004
updateTrackers	[UpdateTracker:9890788] Update Tracker - [SimpleEntity:30004] 2M3OPROA [mitochondrial matrix] - v52:[addName] [UpdateTracker:9902761] Update Tracker - [SimpleEntity:30004] 2M3OPROA [mitochondrial matrix] - v78:[add_removeReferenceEntity] [UpdateTracker:9892730] Update Tracker - [SimpleEntity:30004] 2M3OPROA [mitochondrial matrix] - v54:[addName] [UpdateTracker:9928553] Update Tracker - [SimpleEntity:30004] 2M3OPROA [mitochondrial matrix] - v91:[add_removeReferenceEntity]

Referrals

(updatedInstance)	[UpdateTracker:9890788] Update Tracker - [SimpleEntity:30004] 2M3OPROA [mitochondrial matrix] - v52:[addName] [UpdateTracker:9902761] Update Tracker - [SimpleEntity:30004] 2M3OPROA [mitochondrial matrix] - v78:[add_removeReferenceEntity] [UpdateTracker:9892730] Update Tracker - [SimpleEntity:30004] 2M3OPROA [mitochondrial matrix] - v54:[addName] [UpdateTracker:9928553] Update Tracker - [SimpleEntity:30004] 2M3OPROA [mitochondrial matrix] - v91:[add_removeReferenceEntity]
(output)	[Reaction:R-RNO-909775] (R)-3-aminoisobutyric acid + pyruvate => 2-methyl-3-oxopropanoate + alanine [Reaction:R-DDI-70885] beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+ [Reaction:R-CEL-70885] beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+ [Reaction:R-DME-70885] beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+ [Reaction:R-GGA-70885] beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+ [Reaction:R-XTR-70885] beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+ [Reaction:R-DRE-70885] beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+ [Reaction:R-SSC-70885] beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+ [Reaction:R-BTA-70885] beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+ [Reaction:R-CFA-70885] beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+ [Reaction:R-RNO-70885] beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+ [Reaction:R-MMU-70885] beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+ [Reaction:R-HSA-70885] beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+
(input)	[Reaction:R-DDI-70893] methylmalonate semialdehyde + NAD+ + CoA + H2O => propionyl-CoA + HCO3- + NADH + H+ [Reaction:R-CEL-70893] methylmalonate semialdehyde + NAD+ + CoA + H2O => propionyl-CoA + HCO3- + NADH + H+ [Reaction:R-DME-70893] methylmalonate semialdehyde + NAD+ + CoA + H2O => propionyl-CoA + HCO3- + NADH + H+ [Reaction:R-GGA-70893] methylmalonate semialdehyde + NAD+ + CoA + H2O => propionyl-CoA + HCO3- + NADH + H+ [Reaction:R-XTR-70893] methylmalonate semialdehyde + NAD+ + CoA + H2O => propionyl-CoA + HCO3- + NADH + H+ [Reaction:R-DRE-70893] methylmalonate semialdehyde + NAD+ + CoA + H2O => propionyl-CoA + HCO3- + NADH + H+ [Reaction:R-SSC-70893] methylmalonate semialdehyde + NAD+ + CoA + H2O => propionyl-CoA + HCO3- + NADH + H+ [Reaction:R-BTA-70893] methylmalonate semialdehyde + NAD+ + CoA + H2O => propionyl-CoA + HCO3- + NADH + H+ [Reaction:R-CFA-70893] methylmalonate semialdehyde + NAD+ + CoA + H2O => propionyl-CoA + HCO3- + NADH + H+ [Reaction:R-RNO-70893] methylmalonate semialdehyde + NAD+ + CoA + H2O => propionyl-CoA + HCO3- + NADH + H+ [Reaction:R-MMU-70893] methylmalonate semialdehyde + NAD+ + CoA + H2O => propionyl-CoA + HCO3- + NADH + H+ [Reaction:R-DDI-508473] methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+ [Reaction:R-CEL-508473] methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+ [Reaction:R-DME-508473] methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+ [Reaction:R-GGA-508473] methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+ [Reaction:R-XTR-508473] methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+ [Reaction:R-DRE-508473] methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+ [Reaction:R-SSC-508473] methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+ [Reaction:R-BTA-508473] methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+ [Reaction:R-CFA-508473] methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+ [Reaction:R-RNO-508473] methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+ [Reaction:R-MMU-508473] methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+ [Reaction:R-HSA-508473] methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+ [Reaction:R-HSA-70893] methylmalonate semialdehyde + NAD+ + CoA + H2O => propionyl-CoA + HCO3- + NADH + H+

© 2026 Reactome

Cite Us!