Reactome | SESN1,2 binds L-leucine and dissociates from GATOR2

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SESN1,2 binds L-leucine and dissociates from GATOR2 Show undefined attributes

category	omitted
compartment	[Compartment:17938] lysosomal membrane
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10546036
displayName	SESN1,2 binds L-leucine and dissociates from GATOR2
eventOf	[Pathway:R-SSC-9639288] Amino acids regulate mTORC1 - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-SSC-9645598] RRAGC,D hydrolyzes GTP - Sus scrofa [Reaction:R-SSC-9639286] RRAGC,D exchanges GTP for GDP - Sus scrofa
inferredFrom	[BlackBoxEvent:R-HSA-9639287] SESN1,2 binds L-leucine and dissociates from GATOR2 - Homo sapiens
input	[Complex:R-SSC-9639275] KICSTOR:GATOR1:GATOR2:SESN1,2 [lysosomal membrane] [SimpleEntity:R-ALL-29588] L-Leu [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	SESN1,2 binds L-leucine and dissociates from GATOR2
output	[Complex:R-SSC-9639281] KICSTOR:GATOR1:GATOR2 [lysosomal membrane] [Complex:R-SSC-9639290] SESN1,2:L-Leu [cytosol]
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:49633] Sus scrofa
stId	R-SSC-9639287
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-9639288] Amino acids regulate mTORC1
(precedingEvent)	[Reaction:R-SSC-9645598] RRAGC,D hydrolyzes GTP [Reaction:R-SSC-9639286] RRAGC,D exchanges GTP for GDP
(inferredTo)	[BlackBoxEvent:R-HSA-9639287] SESN1,2 binds L-leucine and dissociates from GATOR2

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