Reactome | 1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol

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1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol Show undefined attributes

catalystActivity	[CatalystActivity:10774880] inositol diphosphate pentakisphosphate diphosphatase activity of NUDT(1) [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10777699
displayName	1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol
eventOf	[Pathway:R-GGA-1855167] Synthesis of pyrophosphates in the cytosol - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-GGA-1855216] IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosol - Gallus gallus [Reaction:R-GGA-1855227] IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol - Gallus gallus [Reaction:R-GGA-1855188] IP6 transports from the cytosol to the nucleus - Gallus gallus
inferredFrom	[Reaction:R-HSA-2023971] 1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol - Homo sapiens
input	[DefinedSet:R-ALL-2023974] 1/3-PP-IP5 [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol
output	[SimpleEntity:R-ALL-1629770] IP6 [cytosol] [SimpleEntity:R-ALL-29372] Pi [cytosol]
precedingEvent	[Reaction:R-GGA-1855216] IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosol - Gallus gallus [Reaction:R-GGA-2023973] (PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol - Gallus gallus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-2023971
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-1855167] Synthesis of pyrophosphates in the cytosol
(precedingEvent)	[Reaction:R-GGA-1855216] IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosol [Reaction:R-GGA-1855227] IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol [Reaction:R-GGA-1855188] IP6 transports from the cytosol to the nucleus
(inferredTo)	[Reaction:R-HSA-2023971] 1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol