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Afatinib [cytosol]
Stable Identifier
R-ALL-1220577
Type
ChemicalDrug
Compartment
cytosol
Synonyms
BIBW2992, Irreversible TKI inhibitor afatinib generic inhibits EGFR and ERBB2 (HER2)
Locations in the PathwayBrowser
for Species:
Homo sapiens
Bos taurus
Caenorhabditis elegans
Canis familiaris
Danio rerio
Drosophila melanogaster
Gallus gallus
Mus musculus
Rattus norvegicus
Sus scrofa
Expand all
Signal Transduction (Bos taurus)
Signaling by Receptor Tyrosine Kinases (Bos taurus)
Signaling by ERBB2 (Bos taurus)
Drug-mediated inhibition of ERBB2 signaling (Bos taurus)
ERBB2 binds TKIs (Bos taurus)
lapatinib, neratinib, afatinib, AZ5104, tesevatinib, canertinib, sapitinib, CP-724714, AEE78 [cytosol]
Afatinib [cytosol]
ERBB2:TKIs:ERBIN:HSP90:CDC37 [plasma membrane] (Bos taurus)
ERBB2:TKIs [plasma membrane] (Bos taurus)
lapatinib, neratinib, afatinib, AZ5104, tesevatinib, canertinib, sapitinib, CP-724714, AEE78 [cytosol]
Afatinib [cytosol]
Trans-autophosphorylation of ERBB2 heterodimers (Bos taurus)
ERBB2:TKIs:ERBIN:HSP90:CDC37 [plasma membrane] (Bos taurus)
ERBB2:TKIs [plasma membrane] (Bos taurus)
lapatinib, neratinib, afatinib, AZ5104, tesevatinib, canertinib, sapitinib, CP-724714, AEE78 [cytosol]
Afatinib [cytosol]
Signal Transduction (Caenorhabditis elegans)
Signaling by Receptor Tyrosine Kinases (Caenorhabditis elegans)
Signaling by ERBB2 (Caenorhabditis elegans)
Drug-mediated inhibition of ERBB2 signaling (Caenorhabditis elegans)
ERBB2 binds TKIs (Caenorhabditis elegans)
lapatinib, neratinib, afatinib, AZ5104, tesevatinib, canertinib, sapitinib, CP-724714, AEE78 [cytosol]
Afatinib [cytosol]
ERBB2:TKIs:ERBIN:HSP90:CDC37 [plasma membrane] (Caenorhabditis elegans)
ERBB2:TKIs [plasma membrane] (Caenorhabditis elegans)
lapatinib, neratinib, afatinib, AZ5104, tesevatinib, canertinib, sapitinib, CP-724714, AEE78 [cytosol]
Afatinib [cytosol]
Trans-autophosphorylation of ERBB2 heterodimers (Caenorhabditis elegans)
ERBB2:TKIs:ERBIN:HSP90:CDC37 [plasma membrane] (Caenorhabditis elegans)
ERBB2:TKIs [plasma membrane] (Caenorhabditis elegans)
lapatinib, neratinib, afatinib, AZ5104, tesevatinib, canertinib, sapitinib, CP-724714, AEE78 [cytosol]
Afatinib [cytosol]
Signal Transduction (Canis familiaris)
Signaling by Receptor Tyrosine Kinases (Canis familiaris)
Signaling by ERBB2 (Canis familiaris)
Drug-mediated inhibition of ERBB2 signaling (Canis familiaris)
ERBB2 binds TKIs (Canis familiaris)
lapatinib, neratinib, afatinib, AZ5104, tesevatinib, canertinib, sapitinib, CP-724714, AEE78 [cytosol]
Afatinib [cytosol]
ERBB2:TKIs:ERBIN:HSP90:CDC37 [plasma membrane] (Canis familiaris)
ERBB2:TKIs [plasma membrane] (Canis familiaris)
lapatinib, neratinib, afatinib, AZ5104, tesevatinib, canertinib, sapitinib, CP-724714, AEE78 [cytosol]
Afatinib [cytosol]
Trans-autophosphorylation of ERBB2 heterodimers (Canis familiaris)
ERBB2:TKIs:ERBIN:HSP90:CDC37 [plasma membrane] (Canis familiaris)
ERBB2:TKIs [plasma membrane] (Canis familiaris)
lapatinib, neratinib, afatinib, AZ5104, tesevatinib, canertinib, sapitinib, CP-724714, AEE78 [cytosol]
Afatinib [cytosol]
Signal Transduction (Danio rerio)
Signaling by Receptor Tyrosine Kinases (Danio rerio)
Signaling by ERBB2 (Danio rerio)
Drug-mediated inhibition of ERBB2 signaling (Danio rerio)
ERBB2 binds TKIs (Danio rerio)
lapatinib, neratinib, afatinib, AZ5104, tesevatinib, canertinib, sapitinib, CP-724714, AEE78 [cytosol]
Afatinib [cytosol]
ERBB2:TKIs:ERBIN:HSP90:CDC37 [plasma membrane] (Danio rerio)
ERBB2:TKIs [plasma membrane] (Danio rerio)
lapatinib, neratinib, afatinib, AZ5104, tesevatinib, canertinib, sapitinib, CP-724714, AEE78 [cytosol]
Afatinib [cytosol]
Trans-autophosphorylation of ERBB2 heterodimers (Danio rerio)
ERBB2:TKIs:ERBIN:HSP90:CDC37 [plasma membrane] (Danio rerio)
ERBB2:TKIs [plasma membrane] (Danio rerio)
lapatinib, neratinib, afatinib, AZ5104, tesevatinib, canertinib, sapitinib, CP-724714, AEE78 [cytosol]
Afatinib [cytosol]
Signal Transduction (Drosophila melanogaster)
Signaling by Receptor Tyrosine Kinases (Drosophila melanogaster)
Signaling by ERBB2 (Drosophila melanogaster)
Drug-mediated inhibition of ERBB2 signaling (Drosophila melanogaster)
ERBB2 binds TKIs (Drosophila melanogaster)
lapatinib, neratinib, afatinib, AZ5104, tesevatinib, canertinib, sapitinib, CP-724714, AEE78 [cytosol]
Afatinib [cytosol]
ERBB2:TKIs:ERBIN:HSP90:CDC37 [plasma membrane] (Drosophila melanogaster)
ERBB2:TKIs [plasma membrane] (Drosophila melanogaster)
lapatinib, neratinib, afatinib, AZ5104, tesevatinib, canertinib, sapitinib, CP-724714, AEE78 [cytosol]
Afatinib [cytosol]
Trans-autophosphorylation of ERBB2 heterodimers (Drosophila melanogaster)
ERBB2:TKIs:ERBIN:HSP90:CDC37 [plasma membrane] (Drosophila melanogaster)
ERBB2:TKIs [plasma membrane] (Drosophila melanogaster)
lapatinib, neratinib, afatinib, AZ5104, tesevatinib, canertinib, sapitinib, CP-724714, AEE78 [cytosol]
Afatinib [cytosol]
Signal Transduction (Gallus gallus)
Signaling by Receptor Tyrosine Kinases (Gallus gallus)
Signaling by ERBB2 (Gallus gallus)
Drug-mediated inhibition of ERBB2 signaling (Gallus gallus)
ERBB2 binds TKIs (Gallus gallus)
lapatinib, neratinib, afatinib, AZ5104, tesevatinib, canertinib, sapitinib, CP-724714, AEE78 [cytosol]
Afatinib [cytosol]
ERBB2:TKIs:ERBIN:HSP90:CDC37 [plasma membrane] (Gallus gallus)
ERBB2:TKIs [plasma membrane] (Gallus gallus)
lapatinib, neratinib, afatinib, AZ5104, tesevatinib, canertinib, sapitinib, CP-724714, AEE78 [cytosol]
Afatinib [cytosol]
Trans-autophosphorylation of ERBB2 heterodimers (Gallus gallus)
ERBB2:TKIs:ERBIN:HSP90:CDC37 [plasma membrane] (Gallus gallus)
ERBB2:TKIs [plasma membrane] (Gallus gallus)
lapatinib, neratinib, afatinib, AZ5104, tesevatinib, canertinib, sapitinib, CP-724714, AEE78 [cytosol]
Afatinib [cytosol]
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Signaling by EGFR in Cancer (Homo sapiens)
Signaling by Ligand-Responsive EGFR Variants in Cancer (Homo sapiens)
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants (Homo sapiens)
Covalent tyrosine kinase inhibitors bind and inactivate EGFR kinase domain mutant dimers resistant to non-covalent tyrosine kinase inhibitors (Homo sapiens)
Covalent EGFR tyrosine kinase inhibitors [cytosol]
Irreversible anti-EGFRplus TKIs [cytosol]
Afatinib [cytosol]
Resistant ligand-responsive EGFR mutants:Covalent EGFR TKIs [plasma membrane] (Homo sapiens)
Covalent EGFR tyrosine kinase inhibitors [cytosol]
Irreversible anti-EGFRplus TKIs [cytosol]
Afatinib [cytosol]
Signaling by Overexpressed Wild-Type EGFR in Cancer (Homo sapiens)
Inhibition of Signaling by Overexpressed EGFR (Homo sapiens)
Covalent tyrosine kinase inhibitors bind and inhibit wild-type EGF:EGFR dimers (Homo sapiens)
Covalent EGFR tyrosine kinase inhibitors [cytosol]
Irreversible anti-EGFRplus TKIs [cytosol]
Afatinib [cytosol]
EGF-like ligands:EGFR Dimer:Covalent EGFR TKIs [plasma membrane] (Homo sapiens)
Covalent EGFR tyrosine kinase inhibitors [cytosol]
Irreversible anti-EGFRplus TKIs [cytosol]
Afatinib [cytosol]
Signaling by ERBB2 in Cancer (Homo sapiens)
Constitutive Signaling by Overexpressed ERBB2 (Homo sapiens)
ERBB2 binds TKIs (Homo sapiens)
lapatinib, neratinib, afatinib, AZ5104, tesevatinib, canertinib, sapitinib, CP-724714, AEE78 [cytosol]
Afatinib [cytosol]
ERBB2:TKIs:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
ERBB2:TKIs [plasma membrane] (Homo sapiens)
lapatinib, neratinib, afatinib, AZ5104, tesevatinib, canertinib, sapitinib, CP-724714, AEE78 [cytosol]
Afatinib [cytosol]
Trans-autophosphorylation of ERBB2 homodimer (Homo sapiens)
lapatinib, neratinib, afatinib, AZ5104, tesevatinib, canertinib, sapitinib, CP-724714, AEE78 [cytosol]
Afatinib [cytosol]
ERBB2:TKIs:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
ERBB2:TKIs [plasma membrane] (Homo sapiens)
lapatinib, neratinib, afatinib, AZ5104, tesevatinib, canertinib, sapitinib, CP-724714, AEE78 [cytosol]
Afatinib [cytosol]
Drug resistance in ERBB2 KD mutants (Homo sapiens)
Resistance of ERBB2 KD mutants to afatinib (Homo sapiens)
ERBB2 T798M does not bind afatinib (Homo sapiens)
Afatinib [cytosol]
Signaling by ERBB2 ECD mutants (Homo sapiens)
ERBB2 ECD mutants bind TKIs (Homo sapiens)
ERBB2 ECD mutants:ERBIN:HSP90:CDC37:TKIs [plasma membrane] (Homo sapiens)
afatinib, neratinib, lapatinib [cytosol] (Homo sapiens)
Afatinib [cytosol]
afatinib, neratinib, lapatinib [cytosol] (Homo sapiens)
Afatinib [cytosol]
Heterodimers of ERBB2 ECD mutants and EGFR trans-autophosphorylate (Homo sapiens)
ERBB2 ECD mutants:ERBIN:HSP90:CDC37:TKIs [plasma membrane] (Homo sapiens)
afatinib, neratinib, lapatinib [cytosol] (Homo sapiens)
Afatinib [cytosol]
afatinib, neratinib, lapatinib [cytosol] (Homo sapiens)
Afatinib [cytosol]
Signaling by ERBB2 KD Mutants (Homo sapiens)
ERBB2 KD mutants bind TKIs (Homo sapiens)
TKIs (ERBB2) [cytosol]
Afatinib [cytosol]
ERBB2 KD mutants:TKIs:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
ERBB2 KD mutants:TKIs [plasma membrane] (Homo sapiens)
ERBB2 KD mutants:afatinib [plasma membrane] (Homo sapiens)
Afatinib [cytosol]
ERBB2 KD mutants trans-autophosphorylate (Homo sapiens)
TKIs (ERBB2) [cytosol]
Afatinib [cytosol]
ERBB2 KD mutants:TKIs:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
ERBB2 KD mutants:TKIs [plasma membrane] (Homo sapiens)
ERBB2 KD mutants:afatinib [plasma membrane] (Homo sapiens)
Afatinib [cytosol]
Signaling by ERBB2 TMD/JMD mutants (Homo sapiens)
ERBB2 TMD/JMD mutants bind TKIs (Homo sapiens)
ERBB2 TMD/JMD mutants (TKI sensitive):TKI:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
ERBB2 TMD/JMD mutants (TKI sensitive):TKIs [plasma membrane] (Homo sapiens)
ERBB2 TMD/JMD mutants (afatinib):afatinib [plasma membrane] (Homo sapiens)
Afatinib [cytosol]
afatinib, neratinib, lapatinib [cytosol] (Homo sapiens)
Afatinib [cytosol]
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by ERBB2 (Homo sapiens)
Drug-mediated inhibition of ERBB2 signaling (Homo sapiens)
ERBB2 binds TKIs (Homo sapiens)
lapatinib, neratinib, afatinib, AZ5104, tesevatinib, canertinib, sapitinib, CP-724714, AEE78 [cytosol]
Afatinib [cytosol]
ERBB2:TKIs:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
ERBB2:TKIs [plasma membrane] (Homo sapiens)
lapatinib, neratinib, afatinib, AZ5104, tesevatinib, canertinib, sapitinib, CP-724714, AEE78 [cytosol]
Afatinib [cytosol]
Trans-autophosphorylation of ERBB2 heterodimers (Homo sapiens)
lapatinib, neratinib, afatinib, AZ5104, tesevatinib, canertinib, sapitinib, CP-724714, AEE78 [cytosol]
Afatinib [cytosol]
ERBB2:TKIs:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
ERBB2:TKIs [plasma membrane] (Homo sapiens)
lapatinib, neratinib, afatinib, AZ5104, tesevatinib, canertinib, sapitinib, CP-724714, AEE78 [cytosol]
Afatinib [cytosol]
Signal Transduction (Mus musculus)
Signaling by Receptor Tyrosine Kinases (Mus musculus)
Signaling by ERBB2 (Mus musculus)
Drug-mediated inhibition of ERBB2 signaling (Mus musculus)
ERBB2 binds TKIs (Mus musculus)
lapatinib, neratinib, afatinib, AZ5104, tesevatinib, canertinib, sapitinib, CP-724714, AEE78 [cytosol]
Afatinib [cytosol]
ERBB2:TKIs:ERBIN:HSP90:CDC37 [plasma membrane] (Mus musculus)
ERBB2:TKIs [plasma membrane] (Mus musculus)
lapatinib, neratinib, afatinib, AZ5104, tesevatinib, canertinib, sapitinib, CP-724714, AEE78 [cytosol]
Afatinib [cytosol]
Trans-autophosphorylation of ERBB2 heterodimers (Mus musculus)
ERBB2:TKIs:ERBIN:HSP90:CDC37 [plasma membrane] (Mus musculus)
ERBB2:TKIs [plasma membrane] (Mus musculus)
lapatinib, neratinib, afatinib, AZ5104, tesevatinib, canertinib, sapitinib, CP-724714, AEE78 [cytosol]
Afatinib [cytosol]
Signal Transduction (Rattus norvegicus)
Signaling by Receptor Tyrosine Kinases (Rattus norvegicus)
Signaling by ERBB2 (Rattus norvegicus)
Drug-mediated inhibition of ERBB2 signaling (Rattus norvegicus)
ERBB2 binds TKIs (Rattus norvegicus)
lapatinib, neratinib, afatinib, AZ5104, tesevatinib, canertinib, sapitinib, CP-724714, AEE78 [cytosol]
Afatinib [cytosol]
ERBB2:TKIs:ERBIN:HSP90:CDC37 [plasma membrane] (Rattus norvegicus)
ERBB2:TKIs [plasma membrane] (Rattus norvegicus)
lapatinib, neratinib, afatinib, AZ5104, tesevatinib, canertinib, sapitinib, CP-724714, AEE78 [cytosol]
Afatinib [cytosol]
Trans-autophosphorylation of ERBB2 heterodimers (Rattus norvegicus)
ERBB2:TKIs:ERBIN:HSP90:CDC37 [plasma membrane] (Rattus norvegicus)
ERBB2:TKIs [plasma membrane] (Rattus norvegicus)
lapatinib, neratinib, afatinib, AZ5104, tesevatinib, canertinib, sapitinib, CP-724714, AEE78 [cytosol]
Afatinib [cytosol]
Signal Transduction (Sus scrofa)
Signaling by Receptor Tyrosine Kinases (Sus scrofa)
Signaling by ERBB2 (Sus scrofa)
Drug-mediated inhibition of ERBB2 signaling (Sus scrofa)
ERBB2 binds TKIs (Sus scrofa)
lapatinib, neratinib, afatinib, AZ5104, tesevatinib, canertinib, sapitinib, CP-724714, AEE78 [cytosol]
Afatinib [cytosol]
ERBB2:TKIs:ERBIN:HSP90:CDC37 [plasma membrane] (Sus scrofa)
ERBB2:TKIs [plasma membrane] (Sus scrofa)
lapatinib, neratinib, afatinib, AZ5104, tesevatinib, canertinib, sapitinib, CP-724714, AEE78 [cytosol]
Afatinib [cytosol]
Trans-autophosphorylation of ERBB2 heterodimers (Sus scrofa)
ERBB2:TKIs:ERBIN:HSP90:CDC37 [plasma membrane] (Sus scrofa)
ERBB2:TKIs [plasma membrane] (Sus scrofa)
lapatinib, neratinib, afatinib, AZ5104, tesevatinib, canertinib, sapitinib, CP-724714, AEE78 [cytosol]
Afatinib [cytosol]
External Reference Information
External Reference
afatinib [Guide to Pharmacology:5667]
Participates
as a member of
Irreversible anti-EGFRplus TKIs [cytosol]
TKIs (ERBB2) [cytosol]
afatinib, neratinib, lapatinib [cytosol] (Homo sapiens)
lapatinib, neratinib, afatinib, AZ5104, tesevatinib, canertinib, sapitinib, CP-724714, AEE78 [cytosol]
as an input of
ERBB2 T798M does not bind afatinib (Homo sapiens)
as a component of
ERBB2 KD mutants:afatinib [plasma membrane] (Homo sapiens)
ERBB2 TMD/JMD mutants (afatinib):afatinib [plasma membrane] (Homo sapiens)
Disease
Name
Identifier
Synonyms
cancer
DOID:162
malignant tumor, malignant neoplasm, primary cancer
Cross References
ChEBI
61390
Pharos - Ligands
L93TLR94JUC1
PharmacoDB
PDBC00031
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