Reactome | Covalent EGFR tyrosine kinase inhibitors [cytosol]

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Covalent EGFR tyrosine kinase inhibitors [cytosol] Show undefined attributes

compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-HSA-1225979] EGF-like ligands:EGFR Dimer:Covalent EGFR TKIs [plasma membrane] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-1225978] Covalent tyrosine kinase inhibitors bind and inhibit wild-type EGF:EGFR dimers - Homo sapiens [Reaction:R-HSA-1225978] Covalent tyrosine kinase inhibitors bind and inhibit wild-type EGF:EGFR dimers - Homo sapiens [Reaction:R-HSA-1220611] Covalent tyrosine kinase inhibitors bind and inactivate EGFR kinase domain mutant dimers resistant to non-covalent tyrosine kinase inhibitors - Homo sapiens [Reaction:R-HSA-1220611] Covalent tyrosine kinase inhibitors bind and inactivate EGFR kinase domain mutant dimers resistant to non-covalent tyrosine kinase inhibitors - Homo sapiens
created	[InstanceEdit:1216529] Orlic-Milacic, Marija, 2011-02-15
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	1216522
disease	[Disease:1500689] cancer
displayName	Covalent EGFR tyrosine kinase inhibitors [cytosol]
hasMember	[DefinedSet:R-ALL-1216530] Irreversible EGFR-specific TKIs [cytosol] [DefinedSet:R-ALL-1216531] Irreversible anti-EGFRplus TKIs [cytosol]
inDisease	true
maxDepth	3
modified	[InstanceEdit:2457820] Orlic-Milacic, M, 2012-08-28
name	Covalent EGFR tyrosine kinase inhibitors Irreversible EGFR TKIs Irreversible anti-EGFR tyrosine kinase inhibitors
schemaClass	DefinedSet
stId	R-ALL-1216522
updateTrackers	[UpdateTracker:9873023] Update Tracker - [DefinedSet:1216522] Covalent EGFR tyrosine kinase inhibitors [cytosol] - v42:[removeSpecies] [UpdateTracker:9872127] Update Tracker - [DefinedSet:1216522] Covalent EGFR tyrosine kinase inhibitors [cytosol] - v41:[updateContainedMemberOrCandidate]

Referrals

(updatedInstance)	[UpdateTracker:9873023] Update Tracker - [DefinedSet:1216522] Covalent EGFR tyrosine kinase inhibitors [cytosol] - v42:[removeSpecies] [UpdateTracker:9872127] Update Tracker - [DefinedSet:1216522] Covalent EGFR tyrosine kinase inhibitors [cytosol] - v41:[updateContainedMemberOrCandidate]
(hasComponent)	[Complex:R-HSA-1225979] EGF-like ligands:EGFR Dimer:Covalent EGFR TKIs [plasma membrane] [Complex:R-HSA-1220579] Resistant ligand-responsive EGFR mutants:Covalent EGFR TKIs [plasma membrane]
(input)	[Reaction:R-HSA-1225978] Covalent tyrosine kinase inhibitors bind and inhibit wild-type EGF:EGFR dimers [Reaction:R-HSA-1220611] Covalent tyrosine kinase inhibitors bind and inactivate EGFR kinase domain mutant dimers resistant to non-covalent tyrosine kinase inhibitors

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