Reactome | Covalent tyrosine kinase inhibitors bind and inhibit wild-type EGF:EGFR dimers

Schema > Reaction > Entries

Covalent tyrosine kinase inhibitors bind and inhibit wild-type EGF:EGFR dimers Show undefined attributes

authored	[InstanceEdit:1972359] Orlic-Milacic, M, 2011-11-04
category	binding
compartment	[Compartment:70101] cytosol [Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:1225980] Orlic-Milacic, Marija, 2011-03-03
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	1225978
disease	[Disease:1500689] cancer
displayName	Covalent tyrosine kinase inhibitors bind and inhibit wild-type EGF:EGFR dimers
edited	[InstanceEdit:1972360] D'Eustachio, P, 2011-11-07 [InstanceEdit:1972361] Matthews, L, 2011-11-07 [InstanceEdit:1990853] Wu, G, 2011-11-07
eventOf	[Pathway:R-HSA-5638303] Inhibition of Signaling by Overexpressed EGFR - Homo sapiens
input	2 × [DefinedSet:R-ALL-1216522] Covalent EGFR tyrosine kinase inhibitors [cytosol] [Complex:R-HSA-9624420] EGF-like ligands:EGFR dimer [plasma membrane]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:1225967] Novel mutant-selective EGFR kinase inhibitors against EGFR T790M
maxDepth	1
modified	[InstanceEdit:9865824] Orlic-Milacic, Marija, 2024-03-19
name	Covalent tyrosine kinase inhibitors bind and inhibit wild-type EGF:EGFR dimers
output	[Complex:R-HSA-1225979] EGF-like ligands:EGFR Dimer:Covalent EGFR TKIs [plasma membrane]
precedingEvent	[Reaction:R-HSA-177922] EGFR dimerization - Homo sapiens
releaseDate	2011-12-06
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1990843] Greulich, H, 2011-11-15 [InstanceEdit:1990844] Savas, S, 2011-11-15
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1225978
summation	[Summation:1247599] Covalent (irreversible) TKIs, pelitinib, WZ4002, HKI-272, ca...
updateTrackers	[UpdateTracker:9778950] Update Tracker - [Reaction:1225978] Covalent tyrosine kinase inhibitors bind and inhibit wild-type EGF:EGFR dimers - v67:[add_removeInput]

Referrals

(updatedInstance)	[UpdateTracker:9778950] Update Tracker - [Reaction:1225978] Covalent tyrosine kinase inhibitors bind and inhibit wild-type EGF:EGFR dimers - v67:[add_removeInput]
(hasEvent)	[Pathway:R-HSA-5638303] Inhibition of Signaling by Overexpressed EGFR

Cite Us!