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Search ...
Go!
Schema
>
ChemicalDrug
>
Entries
sorafenib [cytosol]
Show undefined attributes
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compartment
[Compartment:70101] cytosol
consumedByEvent
[FailedReaction:R-HSA-9674414] Sorafenib-resistant PDGFR mutants don't bind sorefenib - Homo sapiens
[FailedReaction:R-HSA-9702623] sorafenib-resistant FLT3 mutants don't bind sorafenib - Homo sapiens
[FailedReaction:R-HSA-9669874] Sorafenib-resistant KIT mutants do not bind sorafenib - Homo sapiens
created
[InstanceEdit:9657030] Rothfels, Karen, 2019-08-06
crossReference
[DatabaseIdentifier:9657024] ChEBI:50924
dbId
9657029
disease
[Disease:1655483] renal clear cell carcinoma
[Disease:2327993] hepatocellular carcinoma
[Disease:1655470] thyroid cancer
displayName
sorafenib [cytosol]
inDisease
true
literatureReference
[LiteratureReference:9656978] BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis
memberOf
[DefinedSet:R-HSA-9694028] small molecule inhibitors of RIPK1, RIPK3 [cytosol] - Homo sapiens
[DefinedSet:R-ALL-9695783] type II FLT3-binding TKIs [cytosol]
[CandidateSet:R-ALL-6802559] BRAF inhibitors [cytosol]
[DefinedSet:R-ALL-9669722] type II KIT binding TKIs [cytosol]
[DefinedSet:R-ALL-9674079] type II PDGFR-binding tyrosine kinase inhibitors [cytosol]
name
sorafenib
referenceEntity
[ReferenceTherapeutic:9657019] sorafenib [Guide to Pharmacology:5711]
schemaClass
ChemicalDrug
stId
R-ALL-9657029
Referrals
(input)
[FailedReaction:R-HSA-9674414] Sorafenib-resistant PDGFR mutants don't bind sorefenib
[FailedReaction:R-HSA-9702623] sorafenib-resistant FLT3 mutants don't bind sorafenib
[FailedReaction:R-HSA-9669874] Sorafenib-resistant KIT mutants do not bind sorafenib
(hasMember)
[CandidateSet:R-ALL-6802559] BRAF inhibitors [cytosol]
[DefinedSet:R-HSA-9694028] small molecule inhibitors of RIPK1, RIPK3 [cytosol]
[DefinedSet:R-ALL-9695783] type II FLT3-binding TKIs [cytosol]
[DefinedSet:R-ALL-9669722] type II KIT binding TKIs [cytosol]
[DefinedSet:R-ALL-9674079] type II PDGFR-binding tyrosine kinase inhibitors [cytosol]
(activeUnit)
[NegativeRegulation:9693970] Negative regulation by 'RIPK1:RIPK3:sorafenib, ponatinib, pazopanib [cytosol]'
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