Reactome | Spatzle (SPZ) dimer binding leads to Toll (TL) receptor homo...

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Spatzle (SPZ) dimer binding leads to Toll (TL) receptor homo... Show undefined attributes

created	[InstanceEdit:9038602] D'Eustachio, Peter, 2018-03-09
dbId	9038601
displayName	Spatzle (SPZ) dimer binding leads to Toll (TL) receptor homo...
modified	[InstanceEdit:9676085] D'Eustachio, Peter, 2020-02-07
schemaClass	Summation
text	Spatzle (SPZ) dimer binding leads to Toll (TL) receptor homodimerisation and activation.

Referrals

(summation)

[Pathway:R-DME-210671] Transcriptional repression by nuclear factors
[Pathway:R-DME-209228] Formation of the activated STAT92E dimer and transport to the nucleus
[Pathway:R-DME-209209] Formation of the activated receptor complex
[Pathway:R-DME-210688] Dephosphorylation by PTP61F phosphatases
[Pathway:R-DME-210693] STAT92E dimer dephosphorylated in the nucleus and transported to the cytosol
[Pathway:R-DME-209400] Transcriptional activtion by phosphorylated DL/DIF dimer
[Pathway:R-DME-209406] Degradation of NF-kappa-B inhibitor, CACT
[Pathway:R-DME-214869] Phosphorylated CACT, DL and DIF homodimers dissociate from the TL receptor 'signalling complex'
[Pathway:R-DME-214844] DL and DIF homodimers complexed with CACT are all phosphorylated in the TL receptor 'signalling complex'
[Pathway:R-DME-214842] DL and DIF homodimers bind to TUB and phosphorylated PLL in the TL receptor 'signalling complex'
[Pathway:R-DME-214862] Activated PLL kinase is autophosphorylated in the TL receptor 'signalling complex'
[Pathway:R-DME-209442] Formation of the trans-membrane 'signalling complex'
[Pathway:R-DME-214874] PLL kinase binds to TUB in the TL receptor 'signalling complex'
[Pathway:R-DME-214863] Adaptor protein complex binds to TL receptor at the plasma membrane
[Pathway:R-DME-450736] Activation of Downstream Effectors
[Pathway:R-DME-350411] Formation and asymmetric localisation of transmembrane complexes
[Pathway:R-DME-450799] RHO1 signalling
[Pathway:R-DME-450728] Inhibition of actin polymerization
[Pathway:R-DME-350480] Activation of non-muscle Myosin II
[Pathway:R-DME-350416] Regulation of non-muscle Myosin II
[Pathway:R-DME-350407] RHO1 GTPase cycle
[Pathway:R-DME-350368] Activation of RHO1 by FZ:DSH complex
[Pathway:R-DME-450724] JNK signalling
[Pathway:R-DME-350369] Negative feedback loop regulates asymmetric localisation
[Pathway:R-DME-350379] Homo-/heterophilic binding of transmembrane components
[Pathway:R-DME-209469] WG ligand bound to FZ receptors
[Pathway:R-DME-209421] Transcription activation by ARM
[Pathway:R-DME-209407] Transport of ARM to the nucleus
[Pathway:R-DME-209440] Recruitment of the 'destruction complex' to the receptor complex, the degradation of AXN and release of ARM
[Pathway:R-DME-209472] Assembly of receptor complex
[Pathway:R-DME-209171] Peptidoglycans (PGN) bind to a peptidoglycan recognition protein receptor, PGRP-LC/LE
[Pathway:R-DME-209266] Peptidoglycan bound PGRP-LC/LE oligomerises
[Pathway:R-DME-214397] Assembly of the PGN:PGRP-LC/LE receptor 'signalling complex'
[Pathway:R-DME-214411] REL binds to DREDD in the PGN:PGRP-LC/LE receptor 'signalling complex'
[Pathway:R-DME-214399] Activated IkappaB kinase (IKK) complex, Phospho IRD5:KEY dimer, phosphorylates REL in the PGN:PGRP-LC/LE receptor 'signalling complex'
[Pathway:R-DME-214416] Phosphorylated REL is cleaved by and dissociates from DREDD
[Pathway:R-DME-209447] Activation of the IkappaB kinase complex, KEY:IRD5 dimer:KEY
[Pathway:R-DME-209438] Formation of the PGN:PGRP-LC/LE receptor 'signalling complex'
[Pathway:R-DME-209465] Catalytic processing of the nuclear factor, REL
[Pathway:R-DME-209394] Transcriptional activtion and repression of REL-68 target genes
[Pathway:R-DME-350376] Activation of RAC1:GTP by FZ:DSH complex
[Pathway:R-DME-209397] Formation of the cytosolic BSK 'scaffolding complex'
[Pathway:R-DME-209409] Formation of the nuclear AP-1 transcription factor 'scaffolding complex'
[Pathway:R-DME-209425] Transcriptional activtion by AP-1 transcription factor
[Pathway:R-DME-209190] Phosphorylation of CI
[Pathway:R-DME-209159] Assembly of the CI containing complexes
[Pathway:R-DME-209360] Ubiquitination and proteolysis of phosphorylated CI
[Pathway:R-DME-209446] N-HH ligand not bound to PTC receptor complex
[Pathway:R-DME-209471] Formation and transport of the N-HH ligand
[Pathway:R-DME-209214] Phosphorylation of SMO
[Pathway:R-DME-209338] Assembly of the 'signalling complexes'
[Pathway:R-DME-216217] Activation of SMO
[Pathway:R-DME-216119] Activation of CI
[Pathway:R-DME-216167] Nuclear CI is degraded
[Pathway:R-DME-209452] N-HH ligand bound to PTC receptor complex
[Pathway:R-DME-538864] Degradation of CRY
[Pathway:R-DME-432395] Degradation of TIM
[Pathway:R-DME-432524] Degradation of PER
[Pathway:R-DME-432560] Transcription activation by CLK:CYC and repression by VRI
[Pathway:R-DME-432620] Dephosphorylation of PER
[Pathway:R-DME-538898] Dephosphorylation of TIM
[Pathway:R-DME-432553] Phosphorylation of PER and TIM
[Pathway:R-DME-432490] Nuclear import of PER and TIM
[Pathway:R-DME-432501] Transcription repression by PER and activation by PDP1
[Pathway:R-DME-432408] Transcription regulation of cwo gene
[Pathway:R-DME-390023] Subcellular localisation of D
[Pathway:R-DME-390089] Formation of the Hippo kinase cassette
[Pathway:R-DME-390098] Phosphorylation-dependent inhibition of YKI
[Pathway:R-DME-451806] Phosphorylation-independent inhibition of YKI
[Pathway:R-DME-390150] DS ligand bound to FT receptor
[Pathway:R-DME-390193] Transcriptional activation by YKI
[Pathway:R-DME-390178] DS ligand not bound to FT receptor
[Pathway:R-DME-209155] Phosphorylation of AXN and APC
[Pathway:R-DME-209396] Phosphorylation of ARM
[Pathway:R-DME-209413] Assembly of the 'destruction complex'
[Pathway:R-DME-209461] Ubiquitination and degradation of phosphorylated ARM
[Pathway:R-DME-209441] WG ligand not bound to FZ receptors
[Pathway:R-DME-209387] Phosphorylation of ARR

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