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Schema
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Pathway
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Entries
Recruitment of the 'destruction complex' to the receptor complex, the degradation of AXN and release of ARM
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authored
[InstanceEdit:386950] Williams, MG, 2006-07-26 16:49:12
compartment
[Compartment:876] plasma membrane
created
[InstanceEdit:205630] Williams, MG, 2006-06-28 10:48:14
dbId
209440
displayName
Recruitment of the 'destruction complex' to the receptor complex, the degradation of AXN and release of ARM
edited
[InstanceEdit:386950] Williams, MG, 2006-07-26 16:49:12
eventOf
[Pathway:R-DME-209469] WG ligand bound to FZ receptors - Drosophila melanogaster
followingEvent
[Pathway:R-DME-209407] Transport of ARM to the nucleus - Drosophila melanogaster
hasDiagram
false
hasEHLD
false
hasEvent
[Reaction:R-DME-209120] Membrane recruitment of DSH to FZ and AXN to phosphorylated ARR - Drosophila melanogaster
[Reaction:R-DME-209112] Inhibition of SGG results in the dephosphorylation of the 'destruction complex' by PP2A and release of ARM - Drosophila melanogaster
[BlackBoxEvent:R-DME-209075] Destabilisation and degradation of AXN in the 'destruction complex' - Drosophila melanogaster
[Reaction:R-DME-209081] Disassembly of the destabilised 'destruction complex' - Drosophila melanogaster
isInDisease
false
isInferred
false
lastUpdatedDate
2020-03-16
literatureReference
[LiteratureReference:208053] Regulation of Wnt signaling by protein-protein interaction and post-translational modifications
[LiteratureReference:208187] Rethinking WNT signaling
[LiteratureReference:208177] The Wnt signaling pathway in development and disease
maxDepth
2
modified
[InstanceEdit:9847082] Weiser, Joel, 2023-10-12
name
Recruitment of the 'destruction complex' to the receptor complex, the degradation of AXN and release of ARM
precedingEvent
[Pathway:R-DME-209472] Assembly of receptor complex - Drosophila melanogaster
releaseDate
2009-03-12
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:386952] Nusse, Roel, 2008-01-19
schemaClass
Pathway
species
[Species:56210] Drosophila melanogaster
stId
R-DME-209440
summation
[Summation:9038601] Spatzle (SPZ) dimer binding leads to Toll (TL) receptor homo...
updateTrackers
[UpdateTracker:9777305] Update Tracker - [Pathway:209440] Recruitment of the 'destruction complex' to the receptor complex, the degradation of AXN and release of ARM - v72:[modifyText]
[UpdateTracker:9779502] Update Tracker - [Pathway:209440] Recruitment of the 'destruction complex' to the receptor complex, the degradation of AXN and release of ARM - v65:[addSummation]
Referrals
(updatedInstance)
[UpdateTracker:9777305] Update Tracker - [Pathway:209440] Recruitment of the 'destruction complex' to the receptor complex, the degradation of AXN and release of ARM - v72:[modifyText]
[UpdateTracker:9779502] Update Tracker - [Pathway:209440] Recruitment of the 'destruction complex' to the receptor complex, the degradation of AXN and release of ARM - v65:[addSummation]
(precedingEvent)
[Pathway:R-DME-209407] Transport of ARM to the nucleus
(hasEvent)
[Pathway:R-DME-209469] WG ligand bound to FZ receptors
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