Reactome | Transcription activation by CLK:CYC and repression by VRI

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Transcription activation by CLK:CYC and repression by VRI Show undefined attributes

authored	[InstanceEdit:432420] Williams, MG, 2009-08-13
created	[InstanceEdit:432644] Williams, MG, 2009-08-14
crossReference	[DatabaseIdentifier:12819453] BioModels Database:BIOMD0000000160
dbId	432560
displayName	Transcription activation by CLK:CYC and repression by VRI
edited	[InstanceEdit:432644] Williams, MG, 2009-08-14
eventOf	[Pathway:R-DME-432626] Circadian Clock pathway - Drosophila melanogaster
followingEvent	[Pathway:R-DME-432408] Transcription regulation of cwo gene - Drosophila melanogaster [Pathway:R-DME-432553] Phosphorylation of PER and TIM - Drosophila melanogaster
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-DME-432516] CLK and CYC bind to form a heterodimer - Drosophila melanogaster [Reaction:R-DME-432436] CLK:CYC heterodimer binds to per, tim, vri, and Pdp1 genes - Drosophila melanogaster [Reaction:R-DME-432607] VRI replaces PDP1 as binder to Clk and cry genes - Drosophila melanogaster
isInDisease	false
isInferred	false
lastUpdatedDate	2020-03-16
literatureReference	[LiteratureReference:432523] The circadian timekeeping system of Drosophila
maxDepth	2
modified	[InstanceEdit:12819426] Weiser, Joel, 2026-02-23
name	Transcription activation by CLK:CYC and repression by VRI
precedingEvent	[Pathway:R-DME-432524] Degradation of PER - Drosophila melanogaster [Pathway:R-DME-432395] Degradation of TIM - Drosophila melanogaster
releaseDate	2010-07-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:909536] Edery, I, 2010-07-06
schemaClass	Pathway
species	[Species:56210] Drosophila melanogaster
stId	R-DME-432560
summation	[Summation:9038601] Spatzle (SPZ) dimer binding leads to Toll (TL) receptor homo...
updateTrackers	[UpdateTracker:9777213] Update Tracker - [Pathway:432560] Transcription activation by CLK:CYC and repression by VRI - v72:[modifyText] [UpdateTracker:9779597] Update Tracker - [Pathway:432560] Transcription activation by CLK:CYC and repression by VRI - v65:[addSummation]

Referrals

(updatedInstance)	[UpdateTracker:9777213] Update Tracker - [Pathway:432560] Transcription activation by CLK:CYC and repression by VRI - v72:[modifyText] [UpdateTracker:9779597] Update Tracker - [Pathway:432560] Transcription activation by CLK:CYC and repression by VRI - v65:[addSummation]
(precedingEvent)	[Pathway:R-DME-432408] Transcription regulation of cwo gene [Pathway:R-DME-432553] Phosphorylation of PER and TIM
(hasEvent)	[Pathway:R-DME-432626] Circadian Clock pathway

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