Reactome | Deletion of instance: 508751

Schema > Deleted > Entries

Deletion of instance: 508751 Show undefined attributes

created	[InstanceEdit:9032449] May, Bruce, 2017-12-12
curatorComment	The deleted pathway was a manually curated mouse pathway whose reactions were used only for inference of human reactions. The reactions contained in the deleted pathway are listed in replacementInstances.
dbId	9032442
deletedInstance	[DeletedInstance:9747324] Deleted Instance - [Pathway: Circadian Clock (508751) - [Species:48892] Mus musculus]
deletedInstanceDbId	508751
displayName	Deletion of instance: 508751
modified	[InstanceEdit:9939552] May, Bruce, 2025-02-28
reason	[DeletedControlledVocabulary:188249] Obsoleted
replacementInstances	[Reaction:R-MMU-549451] Cry proteins stabilize unphosphorylated Bmal1:Clock,Npas2 - Mus musculus [Reaction:R-MMU-9932534] Btrc:Cul1:Skp1:Rbx1 binds phosphorylated Per1,2,3 - Mus musculus [BlackBoxEvent:R-MMU-9932501] Fbxl3:Cul1:Skp1:Rbx1 ubiquitinylates phosphorylated Cry1,2 - Mus musculus [Reaction:R-MMU-9927987] p-S-Cry:p-S-Per:Csnk1d,e binds p-S97,Ac-K544-Bmal1:p-T451,T461,S440,S441,S446-Clock:Nr1d1 gene - Mus musculus [Reaction:R-NUL-9932082] Cdk5 phosphorylates CLOCK on serine 451 and serine-461 - Homo sapiens [Reaction:R-MMU-9909394] Csnk1e,Csnk1d phosphorylate Cry and Per proteins - Mus musculus [Reaction:R-MMU-9920721] p-S97-Bmal1 binds p-T451,T461-Clock - Mus musculus [BlackBoxEvent:R-MMU-9909360] Formation of Cry:Per:Kinase complex - Mus musculus [BlackBoxEvent:R-HSA-9920665] p-S90-BMAL1:p-T451,T461-CLOCK translocates from the cytosol to the nucleus - Homo sapiens [BlackBoxEvent:R-MMU-9932505] Btrc:Cul1:Skp1:Rbx1 ubiquitinylates phosphorylated Per1,2,3 - Mus musculus [Reaction:R-MMU-9932519] Fbxl3:Cul1:Skp1:Rbx1 binds phosphorylated Cry1,2 - Mus musculus [BlackBoxEvent:R-MMU-9909538] Phosphorylated Cry:Per:Csnk1d,e complex translocates from the cytosol to the nucleus - Mus musculus [Reaction:R-MMU-9912393] CK2alpha phosphorylates Bmal1 (Arntl) on serine-97 - Mus musculus [BlackBoxEvent:R-MMU-9932872] Fbxl21:Cul1:Skp1:Rbx1 ubiquitinylates phosphorylated Cry1,2 - Mus musculus
schemaClass	Deleted