Reactome | Cdk5 phosphorylates CLOCK on serine 451 and serine-461

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Cdk5 phosphorylates CLOCK on serine 451 and serine-461 Show undefined attributes

authored	[InstanceEdit:9932068] May, Bruce, 2024-12-15
catalystActivity	[CatalystActivity:9920653] protein serine/threonine kinase activity of Cdk5 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9932069] May, Bruce, 2024-12-17
dbId	9932082
deleted	[Deleted:9939502] Deletion of instance: 508656 [Deleted:9032442] Deletion of instance: 508751 [Deleted:9032440] Deletion of instance: 5334727
displayName	Cdk5 phosphorylates CLOCK on serine 451 and serine-461
edited	[InstanceEdit:9932068] May, Bruce, 2024-12-15
input	2 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [EntityWithAccessionedSequence:R-HSA-400392] CLOCK [cytosol]
isChimeric	true
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9912394] Cyclin-dependent kinase 5 (Cdk5) regulates the function of CLOCK protein by direct phosphorylation
maxDepth	1
modified	[InstanceEdit:9938697] May, Bruce, 2025-02-18
name	Cdk5 phosphorylates CLOCK on serine 451 and serine-461
orthologousEvent	[Reaction:R-HSA-9912396] CDK5 phosphorylates CLOCK on serine-451 and serine-461 - Homo sapiens
output	2 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [EntityWithAccessionedSequence:R-HSA-9912397] p-T451,T461-CLOCK [cytosol]
previousReviewStatus	[ReviewStatus:9821383] three stars
releaseDate	2025-03-26
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9938389] Sancar, Aziz, 2025-02-14 [InstanceEdit:9938694] Albrecht, Urs, 2025-02-18
schemaClass	Reaction
species	[Species:48887] Homo sapiens [Species:48892] Mus musculus
stId	R-NUL-9932082
summation	[Summation:9928750] Cyclin-dependent kinase 5 (CDK5) phosphorylates CLOCK on ser...

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