Reactome | Fbxl3:Cul1:Skp1:Rbx1 ubiquitinylates phosphorylated Cry1,2

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Fbxl3:Cul1:Skp1:Rbx1 ubiquitinylates phosphorylated Cry1,2 Show undefined attributes

authored	[InstanceEdit:9932569] May, Bruce, 2024-12-20
category	omitted
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9932525] May, Bruce, 2024-12-20
dbId	9932501
deleted	[Deleted:9939520] Deletion of instance: 517959 [Deleted:9032442] Deletion of instance: 508751 [Deleted:9032440] Deletion of instance: 5334727
displayName	Fbxl3:Cul1:Skp1:Rbx1 ubiquitinylates phosphorylated Cry1,2
edited	[InstanceEdit:9932569] May, Bruce, 2024-12-20
input	[Complex:R-MMU-9932490] Fbxl3:Cul1:Skp1:Rbx1:p-S-Cry1,2 [nucleoplasm] 3 × [Complex:R-MMU-9932507] Ub:Ube2d1 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:400236] SCFFbxl3 controls the oscillation of the circadian clock by directing the degradation of cryptochrome proteins [LiteratureReference:9932516] Competing E3 ubiquitin ligases govern circadian periodicity by degradation of CRY in nucleus and cytoplasm [LiteratureReference:9932876] FBXL21 regulates oscillation of the circadian clock through ubiquitination and stabilization of cryptochromes
maxDepth	1
modified	[InstanceEdit:9939539] May, Bruce, 2025-02-28
name	Fbxl3:Cul1:Skp1:Rbx1 ubiquitinylates phosphorylated Cry1,2
orthologousEvent	[BlackBoxEvent:R-HSA-9932512] FBXL3:CUL1:SKP1:RBX1 ubiquitinylates phosphorylated CRY1,2 - Homo sapiens
output	[Complex:R-MMU-9932511] Fbxl3:Cul1:Skp1:Rbx1 [nucleoplasm] [DefinedSet:R-MMU-517929] K48polyUb,p-S-Cry1,2 [nucleoplasm] 3 × [EntityWithAccessionedSequence:R-MMU-9932492] Ube2d1 [nucleoplasm]
previousReviewStatus	[ReviewStatus:9821383] three stars
releaseDate	2025-03-26
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9938389] Sancar, Aziz, 2025-02-14 [InstanceEdit:9938694] Albrecht, Urs, 2025-02-18
schemaClass	BlackBoxEvent
species	[Species:48892] Mus musculus
stId	R-MMU-9932501
summation	[Summation:9933314] The Fbxl3:Cul1:Skp1:Rbx1 SCF E3 ligase complex polyubiqutiny...

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