Reactome | Formation of Cry:Per:Kinase complex

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Formation of Cry:Per:Kinase complex Show undefined attributes

authored	[InstanceEdit:9909380] May, Bruce, 2024-05-13
category	omitted
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9909380] May, Bruce, 2024-05-13
dbId	9909360
deleted	[Deleted:9939516] Deletion of instance: 1856952 [Deleted:9032442] Deletion of instance: 508751 [Deleted:9032440] Deletion of instance: 5334727
displayName	Formation of Cry:Per:Kinase complex
edited	[InstanceEdit:9909380] May, Bruce, 2024-05-13
input	[EntityWithAccessionedSequence:R-MMU-508637] Cry1 [cytosol] [EntityWithAccessionedSequence:R-MMU-508614] Cry2 [cytosol] [DefinedSet:R-MMU-508702] Csnk1d,Csnk1e [cytosol] [EntityWithAccessionedSequence:R-MMU-508663] Per1 [cytosol] [EntityWithAccessionedSequence:R-MMU-508621] Per2 [cytosol] [EntityWithAccessionedSequence:R-MMU-9909383] Per3 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:549540] mCRY1 and mCRY2 are essential components of the negative limb of the circadian clock feedback loop [LiteratureReference:508611] Essential roles of CKIdelta and CKIepsilon in the mammalian circadian clock [LiteratureReference:508630] Nuclear entry of the circadian regulator mPER1 is controlled by mammalian casein kinase I epsilon [LiteratureReference:508629] Direct association between mouse PERIOD and CKIepsilon is critical for a functioning circadian clock [LiteratureReference:421281] The circadian regulatory proteins BMAL1 and cryptochromes are substrates of casein kinase Iepsilon [LiteratureReference:5663106] Molecular assembly of the period-cryptochrome circadian transcriptional repressor complex [LiteratureReference:9909363] Macromolecular Assemblies of the Mammalian Circadian Clock [LiteratureReference:9909390] Analysis of mammalian circadian clock protein complexes over a circadian cycle [LiteratureReference:9920677] Cyclin-dependent kinase 5 (CDK5) regulates the circadian clock [LiteratureReference:549411] Analysis of clock proteins in mouse SCN demonstrates phylogenetic divergence of the circadian clockwork and resetting mechanisms [LiteratureReference:879801] Light-independent role of CRY1 and CRY2 in the mammalian circadian clock
maxDepth	1
modified	[InstanceEdit:9938697] May, Bruce, 2025-02-18
name	Formation of Cry:Per:Kinase complex
orthologousEvent	[BlackBoxEvent:R-HSA-9909392] Formation of CRY:PER:Kinase complex - Homo sapiens
output	[Complex:R-MMU-9909387] Cry1:Cry2:Per1:Per2:Per3:Csnk1e,Csnk1d [cytosol]
previousReviewStatus	[ReviewStatus:9821383] three stars
releaseDate	2025-03-26
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9938389] Sancar, Aziz, 2025-02-14 [InstanceEdit:9938694] Albrecht, Urs, 2025-02-18
schemaClass	BlackBoxEvent
species	[Species:48892] Mus musculus
stId	R-MMU-9909360
summation	[Summation:9930074] Cryptochrome (Cry1, Cry2) proteins, Period (Per1, Per2, Per3...

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