5Beta-cholesten-7alpha-ol-3-one and NADPH + H+ form 5beta-ch...

created [InstanceEdit:191989] Jassal, Bijay, 2007-01-26
dbId 192057
displayName 5Beta-cholesten-7alpha-ol-3-one and NADPH + H+ form 5beta-ch...
literatureReference
modified [InstanceEdit:193768] D'Eustachio, P, 2007-02-23 20:48:08
schemaClass Summation
text 5Beta-cholesten-7alpha-ol-3-one and NADPH + H+ form 5beta-cholestan-3alpha,7alpha-diol and NAPDP+. The reaction is catalyzed by 3alpha-hydroxysteroid dehydrogenase (AKR1C4), a cytosolic enzyme belonging to the aldo-keto reductase family (Dufort et al. 2001). Biochemical studies with rat proteins raise the possibility that other related enzymes may also carry out this reaction in vivo (Russell 2003).
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