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phospho-Raf1 [plasma membrane]
Stable Identifier
R-RNO-5672665
Type
Protein [EntityWithAccessionedSequence]
Species
Rattus norvegicus
Compartment
plasma membrane
Synonyms
p-S338,Y341,T491,S494,S621 RAF1, P11345
Locations in the PathwayBrowser
Expand all
Signal Transduction (Rattus norvegicus)
MAPK family signaling cascades (Rattus norvegicus)
MAPK1/MAPK3 signaling (Rattus norvegicus)
RAF/MAP kinase cascade (Rattus norvegicus)
MAP2K and MAPK activation (Rattus norvegicus)
Dissociation of RAS:RAF complex (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Rattus norvegicus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Rattus norvegicus)
activated RAF/KSR1 [plasma membrane] (Rattus norvegicus)
phospho-Raf1 [plasma membrane] (Rattus norvegicus)
p21RAS:GTP:activated RAF homo/heterodimers [plasma membrane] (Rattus norvegicus)
activated RAF/KSR1 [plasma membrane] (Rattus norvegicus)
phospho-Raf1 [plasma membrane] (Rattus norvegicus)
Dual mechanism MAP2K inhibitors bind MAP2Ks (Rattus norvegicus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Rattus norvegicus)
activated RAF/KSR1 [plasma membrane] (Rattus norvegicus)
phospho-Raf1 [plasma membrane] (Rattus norvegicus)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Rattus norvegicus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Rattus norvegicus)
activated RAF/KSR1 [plasma membrane] (Rattus norvegicus)
phospho-Raf1 [plasma membrane] (Rattus norvegicus)
Dual mechanism MAPK inhibitors bind MAPKs (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Rattus norvegicus)
activated RAF/KSR1 [plasma membrane] (Rattus norvegicus)
phospho-Raf1 [plasma membrane] (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Rattus norvegicus)
activated RAF/KSR1 [plasma membrane] (Rattus norvegicus)
phospho-Raf1 [plasma membrane] (Rattus norvegicus)
MAP2Ks and MAPKs bind to the activated RAF complex (Rattus norvegicus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Rattus norvegicus)
activated RAF/KSR1 [plasma membrane] (Rattus norvegicus)
phospho-Raf1 [plasma membrane] (Rattus norvegicus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Rattus norvegicus)
activated RAF/KSR1 [plasma membrane] (Rattus norvegicus)
phospho-Raf1 [plasma membrane] (Rattus norvegicus)
p21 RAS:GTP:activated RAF1 homo/heterodimer:PEBP1 [plasma membrane] (Rattus norvegicus)
p21RAS:GTP:activated RAF1 homo/heterodimer [plasma membrane] (Rattus norvegicus)
phospho-Raf1 [plasma membrane] (Rattus norvegicus)
MAP2Ks phosphorylate MAPKs (Rattus norvegicus)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Rattus norvegicus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Rattus norvegicus)
activated RAF/KSR1 [plasma membrane] (Rattus norvegicus)
phospho-Raf1 [plasma membrane] (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Rattus norvegicus)
activated RAF/KSR1 [plasma membrane] (Rattus norvegicus)
phospho-Raf1 [plasma membrane] (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Rattus norvegicus)
activated RAF/KSR1 [plasma membrane] (Rattus norvegicus)
phospho-Raf1 [plasma membrane] (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Rattus norvegicus)
activated RAF/KSR1 [plasma membrane] (Rattus norvegicus)
phospho-Raf1 [plasma membrane] (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Rattus norvegicus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Rattus norvegicus)
activated RAF/KSR1 [plasma membrane] (Rattus norvegicus)
phospho-Raf1 [plasma membrane] (Rattus norvegicus)
RAF phosphorylates MAP2K dimer (Rattus norvegicus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Rattus norvegicus)
activated RAF/KSR1 [plasma membrane] (Rattus norvegicus)
phospho-Raf1 [plasma membrane] (Rattus norvegicus)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Rattus norvegicus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Rattus norvegicus)
activated RAF/KSR1 [plasma membrane] (Rattus norvegicus)
phospho-Raf1 [plasma membrane] (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Rattus norvegicus)
activated RAF/KSR1 [plasma membrane] (Rattus norvegicus)
phospho-Raf1 [plasma membrane] (Rattus norvegicus)
Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Rattus norvegicus)
activated RAF/KSR1 [plasma membrane] (Rattus norvegicus)
phospho-Raf1 [plasma membrane] (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Rattus norvegicus)
activated RAF/KSR1 [plasma membrane] (Rattus norvegicus)
phospho-Raf1 [plasma membrane] (Rattus norvegicus)
Single mechanism MAPK inhibitors bind phosphorylated MAPK (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Rattus norvegicus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Rattus norvegicus)
activated RAF/KSR1 [plasma membrane] (Rattus norvegicus)
phospho-Raf1 [plasma membrane] (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors [plasma membrane] (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Rattus norvegicus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Rattus norvegicus)
activated RAF/KSR1 [plasma membrane] (Rattus norvegicus)
phospho-Raf1 [plasma membrane] (Rattus norvegicus)
Negative regulation of MAPK pathway (Rattus norvegicus)
Negative feedback regulation of MAPK pathway (Rattus norvegicus)
Activated MAPK phosphorylates RAF1 (Rattus norvegicus)
phospho-Raf1 [plasma membrane] (Rattus norvegicus)
PEBP1 binds activated RAF1 (Rattus norvegicus)
p21 RAS:GTP:activated RAF1 homo/heterodimer:PEBP1 [plasma membrane] (Rattus norvegicus)
p21RAS:GTP:activated RAF1 homo/heterodimer [plasma membrane] (Rattus norvegicus)
phospho-Raf1 [plasma membrane] (Rattus norvegicus)
p21RAS:GTP:activated RAF1 homo/heterodimer [plasma membrane] (Rattus norvegicus)
phospho-Raf1 [plasma membrane] (Rattus norvegicus)
PP5 dephosphorylates RAF1 S338 (Rattus norvegicus)
p21RAS:GTP:activated RAF1 homo/heterodimer [plasma membrane] (Rattus norvegicus)
phospho-Raf1 [plasma membrane] (Rattus norvegicus)
RAF activation (Rattus norvegicus)
Phosphorylation of RAF (Rattus norvegicus)
RAF activating kinases [plasma membrane] (Rattus norvegicus)
phospho-Raf1 [plasma membrane] (Rattus norvegicus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Rattus norvegicus)
activated RAF/KSR1 [plasma membrane] (Rattus norvegicus)
phospho-Raf1 [plasma membrane] (Rattus norvegicus)
External Reference Information
External Reference
UniProt:P11345 Raf1
Gene Names
Raf1, Raf
Chain
chain:1-648
Reference Genes
BioGPS Gene:24703 Raf1
ENSEMBL:ENSRNOG00000010153 Raf1
KEGG Gene (Rattus norvegicus):24703 Raf1
Monarch:24703 Raf1
NCBI Gene:24703 Raf1
UCSC:P11345 Raf1
Reference Transcript
RefSeq:NM_012639.2 Raf1
Other Identifiers
10864738
1369932_a_at
17793960
24703
5636675
5648222
5665735
5667067
5717270
5754813
5777273
5806890
5820433
5827748
5858082
5879191
5997348
6144513
6221439
6343749
6348916
6436722
6517783
A_44_P409696
GE19876
GO:0003674
GO:0004672
GO:0005524
GO:0006464
GO:0006468
GO:0007165
GO:0008150
GO:0016301
GO:0035556
GO:0043167
ILMN_1369837
M15427_s_at
M15428complete_seq_at
Participates
as an input of
Activated MAPK phosphorylates RAF1 (Rattus norvegicus)
as a candidate of
RAF activating kinases [plasma membrane] (Rattus norvegicus)
as a component of
p21RAS:GTP:activated RAF1 homo/heterodimer [plasma membrane] (Rattus norvegicus)
as a member of
activated RAF/KSR1 [plasma membrane] (Rattus norvegicus)
Other forms of this molecule
Raf1 [cytosol]
phospho-Raf1 [cytosol]
phospho-Raf1 [cytosol]
RAF proto-oncogene serine/threonine-protein kinase [cytosol]
p-S,T-Raf1 [cytosol]
phospho-Raf1 [plasma membrane]
phospho-Raf1 [plasma membrane]
phospho-Raf1 [plasma membrane]
phospho-Raf1 [cytosol]
Raf1 [cytosol]
phospho-Raf1 [cytosol]
phospho-Raf1 [cytosol]
Inferred From
p-S338,Y341,T491,S494,S621 RAF1 [plasma membrane]
(Homo sapiens)
Modified Residues
Name
O-phospho-L-serine at 621 (in Homo sapiens)
Coordinate
621
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O4'-phospho-L-tyrosine at 341 (in Homo sapiens)
Coordinate
341
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O-phospho-L-serine at 338 (in Homo sapiens)
Coordinate
338
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-threonine at 491 (in Homo sapiens)
Coordinate
491
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O-phospho-L-serine at 494 (in Homo sapiens)
Coordinate
494
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
NP_036771.1
Ensembl
ENSRNOG00000010153
,
ENSRNOT00000013831
,
ENSRNOP00000013831
PRO
P11345
RGD
3531
PDB
1RRB
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P29066
5
Arrb1 [cytoplasmic vesicle membrane]
(R-RNO-351187)
Arrb1 [Golgi membrane]
(R-RNO-350831)
Arrb1 [lysosomal membrane]
(R-RNO-432701)
Arrb1 [cytosol]
(R-RNO-6783186)
Arrb1 [cytosol]
(R-RNO-264470)
0.537
5
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