Reactome | phospho-p-Y397-PTK2 [cytosol]

phospho-p-Y397-PTK2 [cytosol]

Stable Identifier

R-RNO-354068

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

cytosol

Synonyms

O35346

Locations in the PathwayBrowser

Expand all

Developmental Biology (Rattus norvegicus)

- Nervous system development (Rattus norvegicus)
  - Axon guidance (Rattus norvegicus)
    - EPH-Ephrin signaling (Rattus norvegicus)
      - EPHB-mediated forward signaling (Rattus norvegicus)
        
        Recruitment of p190RhoGEF to p-FAK (Rattus norvegicus)
        
        EFNBs:p-EPHBs:p-Y397-PTK2 [plasma membrane] (Rattus norvegicus)
        
        phospho-p-Y397-PTK2 [cytosol] (Rattus norvegicus)
        
        EFNBs:p-EPHBs:p-Y397-PTK2:ARHGEF28 [plasma membrane] (Rattus norvegicus)
        
        EFNBs:p-EPHBs:p-Y397-PTK2 [plasma membrane] (Rattus norvegicus)
        
        phospho-p-Y397-PTK2 [cytosol] (Rattus norvegicus)
        
        p190RhoGEF exchanges GTP for GDP on RHOA, activating it (Rattus norvegicus)
        
        EFNBs:p-EPHBs:p-Y397-PTK2:ARHGEF28 [plasma membrane] (Rattus norvegicus)
        
        EFNBs:p-EPHBs:p-Y397-PTK2 [plasma membrane] (Rattus norvegicus)
        
        phospho-p-Y397-PTK2 [cytosol] (Rattus norvegicus)
    - Netrin-1 signaling (Rattus norvegicus)
      - DCC mediated attractive signaling (Rattus norvegicus)
        
        Activation of Cdc42 (Rattus norvegicus)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane] (Rattus norvegicus)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1 [plasma membrane] (Rattus norvegicus)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN [plasma membrane] (Rattus norvegicus)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2 [plasma membrane] (Rattus norvegicus)
        
        phospho-p-Y397-PTK2 [cytosol] (Rattus norvegicus)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO:CDC42:GTP [plasma membrane] (Rattus norvegicus)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane] (Rattus norvegicus)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1 [plasma membrane] (Rattus norvegicus)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN [plasma membrane] (Rattus norvegicus)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2 [plasma membrane] (Rattus norvegicus)
        
        phospho-p-Y397-PTK2 [cytosol] (Rattus norvegicus)
        
        Activation of Rac1 (Rattus norvegicus)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane] (Rattus norvegicus)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1 [plasma membrane] (Rattus norvegicus)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN [plasma membrane] (Rattus norvegicus)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2 [plasma membrane] (Rattus norvegicus)
        
        phospho-p-Y397-PTK2 [cytosol] (Rattus norvegicus)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO:RAC1:GTP [plasma membrane] (Rattus norvegicus)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane] (Rattus norvegicus)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1 [plasma membrane] (Rattus norvegicus)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN [plasma membrane] (Rattus norvegicus)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2 [plasma membrane] (Rattus norvegicus)
        
        phospho-p-Y397-PTK2 [cytosol] (Rattus norvegicus)
        
        DCC interacting NCK-1 (Rattus norvegicus)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN [plasma membrane] (Rattus norvegicus)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2 [plasma membrane] (Rattus norvegicus)
        
        phospho-p-Y397-PTK2 [cytosol] (Rattus norvegicus)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1 [plasma membrane] (Rattus norvegicus)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN [plasma membrane] (Rattus norvegicus)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2 [plasma membrane] (Rattus norvegicus)
        
        phospho-p-Y397-PTK2 [cytosol] (Rattus norvegicus)
        
        Phosphorylation of DCC by Fyn (Rattus norvegicus)
        
        NTN1:DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN [plasma membrane] (Rattus norvegicus)
        
        NTN1:DCC oligomer:p-Y397-PTK2 [plasma membrane] (Rattus norvegicus)
        
        phospho-p-Y397-PTK2 [cytosol] (Rattus norvegicus)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN [plasma membrane] (Rattus norvegicus)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2 [plasma membrane] (Rattus norvegicus)
        
        phospho-p-Y397-PTK2 [cytosol] (Rattus norvegicus)
        
        RhoGTPase GEF's recruited to DCC (Rattus norvegicus)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1 [plasma membrane] (Rattus norvegicus)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN [plasma membrane] (Rattus norvegicus)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2 [plasma membrane] (Rattus norvegicus)
        
        phospho-p-Y397-PTK2 [cytosol] (Rattus norvegicus)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane] (Rattus norvegicus)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1 [plasma membrane] (Rattus norvegicus)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN [plasma membrane] (Rattus norvegicus)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2 [plasma membrane] (Rattus norvegicus)
        
        phospho-p-Y397-PTK2 [cytosol] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:O35346 Ptk2

Gene Names

Ptk2, Fak, Fak1

Chain

initiator methionine:1, chain:2-1055

Reference Genes

BioGPS Gene:25614 Ptk2

KEGG:rno:25614 Ptk2

Monarch:25614 Ptk2

NCBI Gene:25614 Ptk2

UCSC:O35346 Ptk2

Reference Transcript

RefSeq:NM_013081.2 Ptk2

Participates

as a component of

as an output of

Phosphorylation of PTK2 (FAK) on tyrosine-397 in response to turbulent blood flow (Rattus norvegicus)

This entity regulates

Positively

PTK2 (FAK) and Gq/11 enhance the degradation of NFKBIA (IkBalpha), phosphorylation of RELA (p65) on serine-536, and translocation of p-S536-RELA:NFKB1 (p65:p50) to the nucleus (Rattus norvegicus)

Other forms of this molecule

FAK1_RAT [cytosol]

phospho-p-Y194,Y397,Y576,Y577-PTK2 [cytosol]

phospho-p-Y194,Y397-PTK2 [cytosol]

phospho-pY-PTK2 [cytosol]

phospho-p-5Y-PTK2 [cytosol]

phospho-p-5Y,S732-PTK2 [cytosol]

phospho-p-6Y,S732-PTK2 [cytosol]

PTK2(773-1052) [cytosol]

PTK2(1-772) [cytosol]

PTK2 [cytosol]

phospho-p-6Y-PTK2 [cytosol]

Inferred From

p-Y397-PTK2 [cytosol] (Homo sapiens)

Modified Residues

Name

O4'-phospho-L-tyrosine at 397 (in Homo sapiens)

Coordinate

397

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

NP_037213.1

ZINC - Substances

FAK1_RAT

ZINC target

O35346

PRO

O35346

RGD

3443

ZINC - Predictions - Purchasable

FAK1_RAT

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O35346 Ptk2	12	FAK1_RAT [cytosol] (R-RNO-548922) phospho-p-Y194,Y397,Y576,Y577-PTK2 [cytosol] (R-RNO-8874613) phospho-p-Y194,Y397-PTK2 [cytosol] (R-RNO-8874600) phospho-pY-PTK2 [cytosol] (R-RNO-9632393) phospho-p-5Y-PTK2 [cytosol] (R-RNO-5218711) phospho-p-5Y,S732-PTK2 [cytosol] (R-RNO-5229006) phospho-p-6Y,S732-PTK2 [cytosol] (R-RNO-5218694) PTK2(773-1052) [cytosol] (R-RNO-202829) PTK2(1-772) [cytosol] (R-RNO-202827) PTK2 [cytosol] (R-RNO-201621) phospho-p-Y397-PTK2 [cytosol] (R-RNO-354068) phospho-p-6Y-PTK2 [cytosol] (R-RNO-354128)	0.721	12
UniProt:Q6P6T5	3	Ocln [plasma membrane] (R-RNO-351854) Ocln [plasma membrane] (R-RNO-351873) Ocln [plasma membrane] (R-RNO-351846)	0.589	2
UniProt:A0A8I5ZZ93 A0A8I5ZZ93			0.463	3

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