Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
phospho-Ptk2 [cytosol]
Stable Identifier
R-RNO-354128
Type
Protein [EntityWithAccessionedSequence]
Species
Rattus norvegicus
Compartment
cytosol
Synonyms
p-6Y-PTK2, O35346
Locations in the PathwayBrowser
Expand all
Developmental Biology (Rattus norvegicus)
Nervous system development (Rattus norvegicus)
Axon guidance (Rattus norvegicus)
NCAM signaling for neurite out-growth (Rattus norvegicus)
NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras (Rattus norvegicus)
Grb2:Sos:pFAK bound to NCAM1:pFyn [plasma membrane] (Rattus norvegicus)
pFAK:Grb2:Sos [cytosol] (Rattus norvegicus)
phospho-Ptk2 [cytosol] (Rattus norvegicus)
Recruitment of Grb2 to pFAK:NCAM1 (Rattus norvegicus)
Grb2:pFAK bound to NCAM1:pFyn [plasma membrane] (Rattus norvegicus)
pFAK:Grb2 [cytosol] (Rattus norvegicus)
phospho-Ptk2 [cytosol] (Rattus norvegicus)
Multiple phosphorylated FAK bound to NCAM:pFyn [plasma membrane] (Rattus norvegicus)
phospho-Ptk2 [cytosol] (Rattus norvegicus)
SOS binds Grb2 bound to pFAK:NCAM1 (Rattus norvegicus)
Grb2:Sos:pFAK bound to NCAM1:pFyn [plasma membrane] (Rattus norvegicus)
pFAK:Grb2:Sos [cytosol] (Rattus norvegicus)
phospho-Ptk2 [cytosol] (Rattus norvegicus)
Grb2:pFAK bound to NCAM1:pFyn [plasma membrane] (Rattus norvegicus)
pFAK:Grb2 [cytosol] (Rattus norvegicus)
phospho-Ptk2 [cytosol] (Rattus norvegicus)
Hemostasis (Rattus norvegicus)
Platelet activation, signaling and aggregation (Rattus norvegicus)
Platelet Aggregation (Plug Formation) (Rattus norvegicus)
Integrin signaling (Rattus norvegicus)
GRB2:SOS provides linkage to MAPK signaling for Integrins (Rattus norvegicus)
Interaction of SOS with GRB2 bound to FADK1 (Rattus norvegicus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
phospho-Ptk2 [cytosol] (Rattus norvegicus)
GRB2:SOS:p-PTK2:Focal adhesion [plasma membrane] (Rattus norvegicus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
phospho-Ptk2 [cytosol] (Rattus norvegicus)
Recruitment of GRB2 to p-PTK2 (Rattus norvegicus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
phospho-Ptk2 [cytosol] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
phospho-Ptk2 [cytosol] (Rattus norvegicus)
Phosphorylation of pPTK2 by SRC (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
phospho-Ptk2 [cytosol] (Rattus norvegicus)
p130Cas linkage to MAPK signaling for integrins (Rattus norvegicus)
Crk binding to p130cas (Rattus norvegicus)
CRK:p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
phospho-Ptk2 [cytosol] (Rattus norvegicus)
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
phospho-Ptk2 [cytosol] (Rattus norvegicus)
Phosphorylation of BCAR1 by SRC-PTK2 complex (Rattus norvegicus)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
phospho-Ptk2 [cytosol] (Rattus norvegicus)
FAK-SRC complex [plasma membrane] (Rattus norvegicus)
phospho-Ptk2 [cytosol] (Rattus norvegicus)
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
phospho-Ptk2 [cytosol] (Rattus norvegicus)
Recruitment of BCAR1 to PTK2 complex (Rattus norvegicus)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
phospho-Ptk2 [cytosol] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
phospho-Ptk2 [cytosol] (Rattus norvegicus)
Signal Transduction (Rattus norvegicus)
Integrin signaling (Rattus norvegicus)
GRB2:SOS provides linkage to MAPK signaling for Integrins (Rattus norvegicus)
Interaction of SOS with GRB2 bound to FADK1 (Rattus norvegicus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
phospho-Ptk2 [cytosol] (Rattus norvegicus)
GRB2:SOS:p-PTK2:Focal adhesion [plasma membrane] (Rattus norvegicus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
phospho-Ptk2 [cytosol] (Rattus norvegicus)
Recruitment of GRB2 to p-PTK2 (Rattus norvegicus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
phospho-Ptk2 [cytosol] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
phospho-Ptk2 [cytosol] (Rattus norvegicus)
Phosphorylation of pPTK2 by SRC (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
phospho-Ptk2 [cytosol] (Rattus norvegicus)
p130Cas linkage to MAPK signaling for integrins (Rattus norvegicus)
Crk binding to p130cas (Rattus norvegicus)
CRK:p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
phospho-Ptk2 [cytosol] (Rattus norvegicus)
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
phospho-Ptk2 [cytosol] (Rattus norvegicus)
Phosphorylation of BCAR1 by SRC-PTK2 complex (Rattus norvegicus)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
phospho-Ptk2 [cytosol] (Rattus norvegicus)
FAK-SRC complex [plasma membrane] (Rattus norvegicus)
phospho-Ptk2 [cytosol] (Rattus norvegicus)
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
phospho-Ptk2 [cytosol] (Rattus norvegicus)
Recruitment of BCAR1 to PTK2 complex (Rattus norvegicus)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
phospho-Ptk2 [cytosol] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
phospho-Ptk2 [cytosol] (Rattus norvegicus)
MAPK family signaling cascades (Rattus norvegicus)
MAPK1/MAPK3 signaling (Rattus norvegicus)
RAF/MAP kinase cascade (Rattus norvegicus)
RAS GEFs promote RAS nucleotide exchange (Rattus norvegicus)
RAS GEFs [plasma membrane] (Rattus norvegicus)
Grb2:Sos:pFAK bound to NCAM1:pFyn [plasma membrane] (Rattus norvegicus)
pFAK:Grb2:Sos [cytosol] (Rattus norvegicus)
phospho-Ptk2 [cytosol] (Rattus norvegicus)
External Reference Information
External Reference
UniProt:O35346 Ptk2
Gene Names
Ptk2, Fak, Fak1
Chain
initiator methionine:1, chain:2-1055
Reference Genes
BioGPS Gene:25614 Ptk2
KEGG:rno:25614 Ptk2
Monarch:25614 Ptk2
NCBI Gene:25614 Ptk2
UCSC:O35346 Ptk2
Reference Transcript
RefSeq:NM_013081.2 Ptk2
Participates
as a component of
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
FAK-SRC complex [plasma membrane] (Rattus norvegicus)
Multiple phosphorylated FAK bound to NCAM:pFyn [plasma membrane] (Rattus norvegicus)
pFAK:Grb2 [cytosol] (Rattus norvegicus)
pFAK:Grb2:Sos [cytosol] (Rattus norvegicus)
Other forms of this molecule
FAK1_RAT [cytosol]
phospho-Ptk2 [cytosol]
phospho-Ptk2 [cytosol]
phospho-Ptk2 [cytosol]
phospho-Ptk2 [cytosol]
phospho-Ptk2 [cytosol]
phospho-Ptk2 [cytosol]
Ptk2 [cytosol]
Ptk2 [cytosol]
Ptk2 [cytosol]
phospho-Ptk2 [cytosol]
Inferred From
p-6Y-PTK2 [cytosol]
(Homo sapiens)
Modified Residues
Name
O4'-phospho-L-tyrosine at 397 (in Homo sapiens)
Coordinate
397
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 576 (in Homo sapiens)
Coordinate
576
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 577 (in Homo sapiens)
Coordinate
577
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 861 (in Homo sapiens)
Coordinate
861
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 925 (in Homo sapiens)
Coordinate
925
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 407 (in Homo sapiens)
Coordinate
407
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
NP_037213.1
ZINC - Substances
FAK1_RAT
ZINC target
O35346
PRO
O35346
RGD
3443
ZINC - Predictions - Purchasable
FAK1_RAT
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O35346 Ptk2
12
FAK1_RAT [cytosol]
(R-RNO-548922)
phospho-Ptk2 [cytosol]
(R-RNO-9632393)
phospho-Ptk2 [cytosol]
(R-RNO-8874613)
phospho-Ptk2 [cytosol]
(R-RNO-8874600)
phospho-Ptk2 [cytosol]
(R-RNO-5218694)
phospho-Ptk2 [cytosol]
(R-RNO-5229006)
phospho-Ptk2 [cytosol]
(R-RNO-5218711)
Ptk2 [cytosol]
(R-RNO-202829)
Ptk2 [cytosol]
(R-RNO-202827)
Ptk2 [cytosol]
(R-RNO-201621)
phospho-Ptk2 [cytosol]
(R-RNO-354068)
phospho-Ptk2 [cytosol]
(R-RNO-354128)
0.721
12
UniProt:Q6P6T5
3
Ocln [plasma membrane]
(R-RNO-351854)
Ocln [plasma membrane]
(R-RNO-351873)
Ocln [plasma membrane]
(R-RNO-351846)
0.589
2
UniProt:Q5XI86
2
PTRH2 [mitochondrial outer membrane]
(R-RNO-5696909)
PolyUb-PTRH2 [mitochondrial outer membrane]
(R-RNO-6783190)
0.463
3
© 2025
Reactome
This website requires cookies and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our
Privacy Notice
.
I agree, dismiss this banner
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text