Sulfate assimilation

Stable Identifier
R-MTU-936635
Type
Pathway
Species
Mycobacterium tuberculosis
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Uptake of sulfur in Mycobacterium tuberculosis happens exclusively through sulfate assimiliation, an abundant molecule in the bacterium's environment. All enzymes participating in this process are non-redundant ie they are essential enzymes. Sulfate is first taken up via an ABC transporter and appended to AMP giving APS and PAPS, which can be considered the activated forms of sulfate and are used in cysteine and sulfolipid biosynthesis (Bhave et al, 2007).

Literature References
PubMed ID Title Journal Year
17970225 Drug targets in mycobacterial sulfur metabolism

Bhave, DP, Muse WB, 3rd, Carroll, KS

Infect Disord Drug Targets 2007
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