Trehalose biosynthesis

Stable Identifier
Mycobacterium tuberculosis
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The non-reducing disaccharide trehalose is found in insects, plants, and microorganisms. In bacteria, it is a storage energy source and is essential for the survival of many stress conditions. In mycobacteria, trehalose is also part of the cell wall and of the 'cord factor' which is important for entry into the host (Elbein et al, 2003; Tropis et al, 2005; Jain & Roy, 2009)

M. tuberculosis has three ways to synthesize trehalose: from UDP-glucose and glucose phosphate (the OtsAB pathway), from maltose (the TreS pathway), and from glycogen (TreYZ pathway). The OtsAB pathway was shown to be essential for the organism. It is not known, however, whether or not the essentiality of trehalose for the mycobacterial growth is directly connected to the biosynthesis of cell wall mycolates (De Smet et al, 2000; Murphy et al, 2005)

Literature References
PubMed ID Title Journal Year
19177348 Effect of trehalose on protein structure

Jain, NK, Roy, I

Protein Sci 2009
15703182 The OtsAB pathway is essential for trehalose biosynthesis in Mycobacterium tuberculosis

Apt, AS, Young, DB, Stewart, GR, McAlister, MS, Robertson, BD, Harris, R, Murphy, HN, Driscoll, PC, Mischenko, VV

J Biol Chem 2005
15901732 The crucial role of trehalose and structurally related oligosaccharides in the biosynthesis and transfer of mycolic acids in Corynebacterineae

Morbach, S, Wolf, A, Krämer, R, Meniche, X, Tropis, M, Gebhardt, H, Strelkov, S, Daffe, M, Schomburg, D, Chami, M

J Biol Chem 2005
10658666 Three pathways for trehalose biosynthesis in mycobacteria

Young, DB, De Smet, KA, Robertson, BD, Brown, IN, Weston, A

Microbiology 2000
12626396 New insights on trehalose: a multifunctional molecule

Elbein, AD, Pastuszak, I, Carroll, D, Pan, YT

Glycobiology 2003
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