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Mycobacterium tuberculosis biological processes
Stable Identifier
R-MTU-870392
Type
Pathway
Species
Mycobacterium tuberculosis
ReviewStatus
5/5
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Mycobacterium tuberculosis biological processes (Mycobacterium tuberculosis)
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Mycobacterium tuberculosis
H37Rv is the laboratory strain most widely used of the pathogen
M. tuberculosis
, an actinobacterium that carries many properties of its family to the extreme. It is not only interesting as one of the top three bacterial killers, with one third of the world having a dormant infection, but also as a model for other mycobacteria regarding the processes of slow growing, dormancy, host interaction, very long chain fatty acid biosynthesis, outer cell wall assembly, as well as sulfolipid, siderophore, and mycothiol biosynthesis.
M. tuberculosis
produces mycolic and phthioceranic acids, the fatty acids with the longest carbon atom chains known. With up to 20 hours, it has the longest reproduction time in mycobacteria. In human macrophages in dormant state, it spends decades without reproduction. Consequently, to fully investigate these properties new methods will have to be invented.
While the treatment of an
M. tuberculosis
infection appears standard in Western countries, it still involves six months of a regime of three antibiotics that have been known for a long time. Not unexpectedly, acceptance and adherence to such a prolonged therapy are less than desired, and this contributes to spontaneous resistance from an already higher than average mutation rate of
M. tuberculosis
due to replication errors. Fueled by the HIV advance, strains of this bacterium are on the rise with resistance to all used antibiotics. For this reason,
M. tuberculosis
is the testbed of new antibiotics development, and it offers the opportunity of many unique and essential biochemical pathways. (Camus et al. 2002; Leibert and Rom, 2010)
Literature References
PubMed ID
Title
Journal
Year
12368430
Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv
Medigue, C
,
Pryor, MJ
,
Cole, ST
,
Camus, JC
Microbiology
2002
20586565
New drugs and regimens for treatment of TB
Leibert, E
,
Rom, WN
Expert Rev Anti Infect Ther
2010
Participants
Events
Mycothiol metabolism
(Mycobacterium tuberculosis)
Trehalose biosynthesis
(Mycobacterium tuberculosis)
Sulfur compound metabolism
(Mycobacterium tuberculosis)
Chorismate via Shikimate Pathway
(Mycobacterium tuberculosis)
Dimycocersyl phthiocerol biosynthesis
(Mycobacterium tuberculosis)
Authored
Stephan, R (2010-06-08)
Reviewed
Warner, D (2010-11-25)
Created
Stephan, R (2010-06-08)
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