Glucose is transferred from UDP-glucose onto glucose-6-phosphate

Stable Identifier
R-MTU-868622
Type
Reaction [transition]
Species
Mycobacterium tuberculosis
Compartment
cytosol
ReviewStatus
5/5
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Glucose is transferred from UDP-glucose onto glucose-6-phosphate
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Trehalose phosphate synthase, which is a tetramer in solution (OtsA tetramer), catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) onto glucose-6-phosphate (G6P) to form alpha,alpha-trehalose-6-phosphate (αα-T6P). The enzyme is stimulated by manganese ions and can also accept ADP-, CDP-, GDP- and TDP-glucose as well as UDP-glucose (De Smet et al. 2000, Pan et al. 2008).
Literature References
PubMed ID Title Journal Year
12473104 Trehalose-phosphate synthase of Mycobacterium tuberculosis. Cloning, expression and properties of the recombinant enzyme

Pan, YT, Carroll, JD, Elbein, AD

Eur J Biochem 2002
10658666 Three pathways for trehalose biosynthesis in mycobacteria

De Smet, KA, Weston, A, Brown, IN, Young, DB, Robertson, BD

Microbiology 2000
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Catalyst Activity

alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity of OtsA tetramer [cytosol]

Physical Entity
OtsA tetramer [cytosol] (Mycobacterium tuberculosis)
Activity
alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity (GO:0003825)
Authored
Stephan, R  (2010-05-29)
Reviewed
Warner, D  (2010-11-25)
Created
Stephan, R  (2010-06-02)
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