Glucose is transferred from UDP-glucose onto glucose-6-phosphate

Stable Identifier
R-MTU-868622
Type
Reaction [transition]
Species
Mycobacterium tuberculosis
Compartment
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Trehalose phosphate synthase, which is a tetramer in solution (OtsA tetramer), catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) onto glucose-6-phosphate (G6P) to form alpha,alpha-trehalose-6-phosphate (αα-T6P). The enzyme is stimulated by manganese ions and can also accept ADP-, CDP-, GDP- and TDP-glucose as well as UDP-glucose (De Smet et al. 2000, Pan et al. 2008).

Literature References
PubMed ID Title Journal Year
10658666 Three pathways for trehalose biosynthesis in mycobacteria

De Smet, KA, Weston, A, Brown, IN, Young, DB, Robertson, BD

Microbiology 2000
12473104 Trehalose-phosphate synthase of Mycobacterium tuberculosis. Cloning, expression and properties of the recombinant enzyme

Pan, YT, Carroll, JD, Elbein, AD

Eur J Biochem 2002
Participants
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Catalyst Activity

alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity of OtsA tetramer [cytosol]

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