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phospho-Shc1 [cytosol]
Stable Identifier
R-MMU-8851895
Type
Genes and Transcripts [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
cytosol
Synonyms
p-Y317-SHC1-2, P98083
Locations in the PathwayBrowser
Expand all
Signal Transduction (Mus musculus)
MAPK family signaling cascades (Mus musculus)
MAPK1/MAPK3 signaling (Mus musculus)
RAF/MAP kinase cascade (Mus musculus)
RAS GEFs promote RAS nucleotide exchange (Mus musculus)
RAS GEFs [plasma membrane] (Mus musculus)
HGF:p-4Y-MET dimer:p-Y317-SHC1-2:GRB2:SOS1 [plasma membrane] (Mus musculus)
HGF:p-4Y-MET dimer:p-Y317-SHC1-2 [plasma membrane] (Mus musculus)
phospho-Shc1 [cytosol] (Mus musculus)
Signaling by GPCR (Mus musculus)
GPCR downstream signalling (Mus musculus)
G alpha (s) signalling events (Mus musculus)
GPER1 signaling (Mus musculus)
p-SHC1 binds integrin alpha5beta1:fibronectin (Mus musculus)
integrin alpha5beta1:Fibronectin matrix:pY-SHC1 [plasma membrane] (Mus musculus)
phospho-Shc1 [cytosol] (Mus musculus)
phospho-Shc1 [cytosol] (Mus musculus)
Signaling by Receptor Tyrosine Kinases (Mus musculus)
Signaling by MET (Mus musculus)
MET activates RAS signaling (Mus musculus)
MET phosphorylates SHC1-2 (Mus musculus)
HGF:p-4Y-MET dimer:p-Y317-SHC1-2 [plasma membrane] (Mus musculus)
phospho-Shc1 [cytosol] (Mus musculus)
RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET (Mus musculus)
HGF:p-4Y-MET dimer:p-Y317-SHC1-2:GRB2:SOS1 [plasma membrane] (Mus musculus)
HGF:p-4Y-MET dimer:p-Y317-SHC1-2 [plasma membrane] (Mus musculus)
phospho-Shc1 [cytosol] (Mus musculus)
SHC1-2 bound to MET recruits GRB2:SOS1 (Mus musculus)
HGF:p-4Y-MET dimer:p-Y317-SHC1-2 [plasma membrane] (Mus musculus)
phospho-Shc1 [cytosol] (Mus musculus)
HGF:p-4Y-MET dimer:p-Y317-SHC1-2:GRB2:SOS1 [plasma membrane] (Mus musculus)
HGF:p-4Y-MET dimer:p-Y317-SHC1-2 [plasma membrane] (Mus musculus)
phospho-Shc1 [cytosol] (Mus musculus)
External Reference Information
External Reference
UniProt:P98083-3 Shc1
Gene Names
Shc1, Shc, ShcA
Other Identifiers
104350_at
10493519
10493530
1422853_at
1422854_at
17399432
17399451
20416
4438479
4464752
4597304
4598666
4611903
4781818
4827703
4831049
4843718
4861442
4866348
4978968
5006563
5040489
5077328
5114887
5151032
5151355
5162067
5230211
5234716
5239308
5244996
5279142
5294395
5334342
5347788
5365949
5475784
5525559
5561997
5567359
93713_at
A_52_P384250
A_55_P1979082
A_65_P17586
GE41902
GO:0001525
GO:0001784
GO:0003012
GO:0003013
GO:0005068
GO:0005154
GO:0005158
GO:0005159
GO:0005168
GO:0005515
GO:0005737
GO:0005739
GO:0005759
GO:0005768
GO:0005829
GO:0005886
GO:0005925
GO:0006351
GO:0006355
GO:0006940
GO:0007010
GO:0007155
GO:0007173
GO:0007507
GO:0008284
GO:0008286
GO:0010008
GO:0012501
GO:0016525
GO:0023052
GO:0030036
GO:0030154
GO:0030182
GO:0030971
GO:0031175
GO:0031410
GO:0035556
GO:0042127
GO:0042742
GO:0042802
GO:0043066
GO:0043226
GO:0043410
GO:0044877
GO:0045892
GO:0045893
GO:0045907
GO:0046875
GO:0048009
GO:0048408
GO:0048661
GO:0048856
GO:0051219
GO:0051721
GO:0060090
GO:0070161
GO:0070374
GO:0070435
GO:0071363
GO:0071864
GO:0090322
GO:0098542
GO:0098609
GO:1990839
ILMN_1236765
ILMN_2637676
ILMN_2716426
ILMN_2957070
Msa.1387.0_s_at
aa119070_s_at
mMC021453
mMC025703
mMR029196
Participates
as an input of
p-SHC1 binds integrin alpha5beta1:fibronectin (Mus musculus)
as a component of
integrin alpha5beta1:Fibronectin matrix:pY-SHC1 [plasma membrane] (Mus musculus)
HGF:p-4Y-MET dimer:p-Y317-SHC1-2 [plasma membrane] (Mus musculus)
Other forms of this molecule
p-Y-Shc1-3 [cytosol]
Shc1-3 [cytosol]
Shc1 [plasma membrane]
Shc1 [plasma membrane]
Shc1 [plasma membrane]
phospho-Shc1 [cytosol]
phospho-Shc1 [cytosol]
Shc1 [cytosol]
phospho-Shc1 [cytosol]
phospho-Shc1 [plasma membrane]
phospho-Shc1 [plasma membrane]
phospho-Shc1 [cytosol]
phospho-Shc1 [cytosol]
phospho-Shc1 [cytosol]
Shc1 [cytosol]
Shc1 [cytosol]
phospho-Shc1 [cytosol]
phospho-Shc1 [cytosol]
Inferred From
pY-SHC1 [cytosol]
(Homo sapiens)
p-Y317-SHC1-2 [cytosol]
(Homo sapiens)
Modified Residues
Name
O4'-phospho-L-tyrosine at 317 (in Homo sapiens)
Coordinate
317
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
NP_001106802.1
,
NP_035498.2
Ensembl
ENSMUST00000107417
,
ENSMUST00000094378
,
ENSMUSP00000091940
,
ENSMUST00000191485
,
ENSMUSP00000103040
,
ENSMUST00000039110
,
ENSMUSP00000140336
,
ENSMUSP00000035361
,
ENSMUSG00000042626
PRO
P98083
MGI
98296
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q60631 Grb2
3
Grb2 [cytosol]
(R-MMU-74686)
Grb2 [plasma membrane]
(R-MMU-202993)
Grb2 [cytosol]
(R-MMU-443287)
0.899
8
UniProt:Q9JKF1
3
Iqgap1 [plasma membrane]
(R-MMU-381681)
Iqgap1 [secretory granule membrane]
(R-MMU-6804803)
Iqgap1 [cytosol]
(R-MMU-5626371)
0.65
5
UniProt:P35831
1
PTPN12 [cytosol]
(R-MMU-432933)
0.558
2
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