Reactome | Shc1 [cytosol]

Shc1 [cytosol]

Stable Identifier

R-MMU-1248757

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

External Reference Information

External Reference

UniProt:P98083 Shc1

Gene Names

Shc1, Shc, ShcA

Chain

chain:1-579

Reference Genes

BioGPS Gene:20416 SHC1

KEGG:mmu:20416 SHC1

Monarch:20416 SHC1

NCBI Gene:20416 SHC1

UCSC:P98083 SHC1

Reference Transcript

Participates

as a component of

as an input of

Epo:p-8Y-Epor:p-12Y-Jak2:Lyn:Irs2:p-Crkl:Rapgef1 binds Shc1 (Mus musculus)
Pik3r11:Pik3ca,b,d (Pi3k), Plcg2 (PLCgamma2), Grb2:Sos1, Shc1 (Shc), Ptpn11 (Shp2), Grb2:Gab2, Grb2:Gab3, Grap2 (MONA), Cbl:Grb2, Inpp5d (SHIP1), Inppl1 (SHIP2) bind p-8Y-Csf1r and are activated (Mus musculus)
Csf3 dimer:2xp-4Y-Csf3r:Lyn:p-Y-Jak1:p-Jak2:p-Syk:p-Hck:p-Tyk2 binds and phosphorylates Shc1, Grb2, Gab2, and Ptpn11 (Mus musculus)
Il15:Il15ra:p-Y-Il2rb:p-Y-Jak1:p-Y-Il2rg:p-Y-Jak3 binds Shc1 (Mus musculus)
Shc1 binds phosphorylated ERBB2:EGFR heterodimers (Homo sapiens)
Shc1 binds phosphorylated ERBB2:ERBB3 heterodimers (Homo sapiens)

Other forms of this molecule

p-Y-Shc1 [cytosol]

Cross References

RefSeq

NP_035498.2, NP_001106802.1

ENSEMBL

ENSMUST00000191485, ENSMUSP00000103040, ENSMUSP00000091940, ENSMUST00000107417, ENSMUST00000039110, ENSMUSP00000140336, ENSMUSG00000042626, ENSMUSP00000035361, ENSMUST00000094378

PRO

P98083

MGI

98296

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q60631 Grb2	1	Grb2 [cytosol] (R-MMU-443287)	0.899	8
UniProt:Q9JKF1	3	Iqgap1 [plasma membrane] (R-MMU-381681) Iqgap1 [secretory granule membrane] (R-MMU-6804803) Iqgap1 [cytosol] (R-MMU-5626371)	0.65	5
UniProt:P35831	1	PTPN12 [cytosol] (R-MMU-432933)	0.558	2