Reactome | phospho-Shc1 [cytosol]

phospho-Shc1 [cytosol]

Stable Identifier

R-MMU-162568

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

p-Y-SHC1, P98083

Locations in the PathwayBrowser

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Immune System (Mus musculus)

- Cytokine Signaling in Immune system (Mus musculus)
  - Signaling by CSF3 (G-CSF) (Mus musculus)
    - p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS (Mus musculus)
      - CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:p-Y-SHC1:GRB2:p-Y643-GAB2:p-Y546,Y584-PTPN11 [plasma membrane] (Mus musculus)
        
        phospho-Shc1 [cytosol] (Mus musculus)
  - Signaling by Interleukins (Mus musculus)
    - Interleukin-2 family signaling (Mus musculus)
      - Interleukin receptor SHC signaling (Mus musculus)
        
        Gab2 binds the p85 subunit of Class 1A PI3 kinases (Mus musculus)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Mus musculus)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Mus musculus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Mus musculus)
        
        phospho-Shc1 [cytosol] (Mus musculus)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Mus musculus)
        
        IL2:IL2R trimer p(Y338) beta subunit:p-SHC:GRB2:GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Mus musculus)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Mus musculus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Mus musculus)
        
        phospho-Shc1 [cytosol] (Mus musculus)
        
        Phosphorylated SHC recruits GRB2:SOS1 (Mus musculus)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Mus musculus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Mus musculus)
        
        phospho-Shc1 [cytosol] (Mus musculus)
        
        Interleukin receptor complexes with activated SHC1:GRB2:SOS1 [plasma membrane] (Mus musculus)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Mus musculus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Mus musculus)
        
        phospho-Shc1 [cytosol] (Mus musculus)
        
        Phosphorylated SHC1 recruits GRB2:GAB2 (Mus musculus)
        
        Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Mus musculus)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:GAB2 [plasma membrane] (Mus musculus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Mus musculus)
        
        phospho-Shc1 [cytosol] (Mus musculus)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Mus musculus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Mus musculus)
        
        phospho-Shc1 [cytosol] (Mus musculus)
        
        Phosphorylated SHC1 recruits SHIP (Mus musculus)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Mus musculus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Mus musculus)
        
        phospho-Shc1 [cytosol] (Mus musculus)
        
        Interleukin receptor complexes with activated SHC1:SHIP1,2 [plasma membrane] (Mus musculus)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Mus musculus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Mus musculus)
        
        phospho-Shc1 [cytosol] (Mus musculus)
        
        SHC1 mediates cytokine-induced phosphorylation of GAB2 (Mus musculus)
        
        Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Mus musculus)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:GAB2 [plasma membrane] (Mus musculus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Mus musculus)
        
        phospho-Shc1 [cytosol] (Mus musculus)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Mus musculus)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Mus musculus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Mus musculus)
        
        phospho-Shc1 [cytosol] (Mus musculus)
        
        The SHC1:SHIP1 complex is stabilized by GRB2 (Mus musculus)
        
        Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Mus musculus)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Mus musculus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Mus musculus)
        
        phospho-Shc1 [cytosol] (Mus musculus)
        
        Interleukin receptor complexes with activated SHC1:SHIP:GRB2 [plasma membrane] (Mus musculus)
        
        Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Mus musculus)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Mus musculus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Mus musculus)
        
        phospho-Shc1 [cytosol] (Mus musculus)
      - Interleukin-15 signaling (Mus musculus)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 binds SOS1,SOS2 (Mus musculus)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 [plasma membrane] (Mus musculus)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1 [plasma membrane] (Mus musculus)
        
        phospho-Shc1 [cytosol] (Mus musculus)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2:SOS [plasma membrane] (Mus musculus)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 [plasma membrane] (Mus musculus)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1 [plasma membrane] (Mus musculus)
        
        phospho-Shc1 [cytosol] (Mus musculus)
      - Interleukin-2 signaling (Mus musculus)
        
        SHC1 bound to IL2 receptor is phosphorylated (Mus musculus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Mus musculus)
        
        phospho-Shc1 [cytosol] (Mus musculus)
    - Interleukin-3, Interleukin-5 and GM-CSF signaling (Mus musculus)
      - Interleukin receptor SHC signaling (Mus musculus)
        
        Gab2 binds the p85 subunit of Class 1A PI3 kinases (Mus musculus)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Mus musculus)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Mus musculus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Mus musculus)
        
        phospho-Shc1 [cytosol] (Mus musculus)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Mus musculus)
        
        IL2:IL2R trimer p(Y338) beta subunit:p-SHC:GRB2:GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Mus musculus)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Mus musculus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Mus musculus)
        
        phospho-Shc1 [cytosol] (Mus musculus)
        
        Phosphorylated SHC recruits GRB2:SOS1 (Mus musculus)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Mus musculus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Mus musculus)
        
        phospho-Shc1 [cytosol] (Mus musculus)
        
        Interleukin receptor complexes with activated SHC1:GRB2:SOS1 [plasma membrane] (Mus musculus)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Mus musculus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Mus musculus)
        
        phospho-Shc1 [cytosol] (Mus musculus)
        
        Phosphorylated SHC1 recruits GRB2:GAB2 (Mus musculus)
        
        Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Mus musculus)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:GAB2 [plasma membrane] (Mus musculus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Mus musculus)
        
        phospho-Shc1 [cytosol] (Mus musculus)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Mus musculus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Mus musculus)
        
        phospho-Shc1 [cytosol] (Mus musculus)
        
        Phosphorylated SHC1 recruits SHIP (Mus musculus)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Mus musculus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Mus musculus)
        
        phospho-Shc1 [cytosol] (Mus musculus)
        
        Interleukin receptor complexes with activated SHC1:SHIP1,2 [plasma membrane] (Mus musculus)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Mus musculus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Mus musculus)
        
        phospho-Shc1 [cytosol] (Mus musculus)
        
        SHC1 mediates cytokine-induced phosphorylation of GAB2 (Mus musculus)
        
        Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Mus musculus)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:GAB2 [plasma membrane] (Mus musculus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Mus musculus)
        
        phospho-Shc1 [cytosol] (Mus musculus)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Mus musculus)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Mus musculus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Mus musculus)
        
        phospho-Shc1 [cytosol] (Mus musculus)
        
        The SHC1:SHIP1 complex is stabilized by GRB2 (Mus musculus)
        
        Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Mus musculus)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Mus musculus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Mus musculus)
        
        phospho-Shc1 [cytosol] (Mus musculus)
        
        Interleukin receptor complexes with activated SHC1:SHIP:GRB2 [plasma membrane] (Mus musculus)
        
        Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Mus musculus)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Mus musculus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Mus musculus)
        
        phospho-Shc1 [cytosol] (Mus musculus)

Signal Transduction (Mus musculus)

- MAPK family signaling cascades (Mus musculus)
  - MAPK1/MAPK3 signaling (Mus musculus)
    - RAF/MAP kinase cascade (Mus musculus)
      - RAS GEFs promote RAS nucleotide exchange (Mus musculus)
        
        RAS GEFs [plasma membrane] (Mus musculus)
        
        GRB2-1:SOS1:p-Y-SHC [cytosol] (Mus musculus)
        
        p-Y-SHC [cytosol] (Mus musculus)
        
        phospho-Shc1 [cytosol] (Mus musculus)
        
        Interleukin receptor complexes with activated SHC1:GRB2:SOS1 [plasma membrane] (Mus musculus)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Mus musculus)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Mus musculus)
        
        phospho-Shc1 [cytosol] (Mus musculus)
- Signaling by Erythropoietin (Mus musculus)
  - Erythropoietin activates RAS (Mus musculus)
    - EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:VAV1 (Mus musculus)
      - EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1:p-Y-SHC1 [plasma membrane] (Mus musculus)
        
        phospho-Shc1 [cytosol] (Mus musculus)
      - EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1:p-Y-SHC1:GRB2:VAV1 [plasma membrane] (Mus musculus)
        
        EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1:p-Y-SHC1 [plasma membrane] (Mus musculus)
        
        phospho-Shc1 [cytosol] (Mus musculus)
- Signaling by Receptor Tyrosine Kinases (Mus musculus)
  - Signaling by NTRKs (Mus musculus)
    - Signaling by NTRK1 (TRKA) (Mus musculus)
      - Signalling to ERKs (Mus musculus)
        
        Signalling to RAS (Mus musculus)
        
        GRB2-1:SOS1 binds p-Y-SHC (Mus musculus)
        
        GRB2-1:SOS1:p-Y-SHC [cytosol] (Mus musculus)
        
        p-Y-SHC [cytosol] (Mus musculus)
        
        phospho-Shc1 [cytosol] (Mus musculus)
        
        p-Y-SHC [cytosol] (Mus musculus)
        
        phospho-Shc1 [cytosol] (Mus musculus)

External Reference Information

External Reference

UniProt:P98083 Shc1

Gene Names

Shc1, Shc, ShcA

Chain

chain:1-579

Reference Genes

BioGPS Gene:20416 SHC1

KEGG:mmu:20416 SHC1

Monarch:20416 SHC1

NCBI Gene:20416 SHC1

UCSC:P98083 SHC1

Reference Transcript

Participates

as a component of

as a member of

p-Y-SHC [cytosol] (Mus musculus)

Other forms of this molecule

Shc1 [cytosol]

phospho-Shc1 [cytosol]

phospho-Shc1 [plasma membrane]

phospho-Shc1 [cytosol]

Shc1 [cytosol]

phospho-Shc1 [cytosol]

Shc1 [plasma membrane]

p-Y-Shc1 [cytosol]

Inferred From

p-Y-SHC1 [cytosol] (Homo sapiens)

Modified Residues

Name

O4'-phospho-L-tyrosine at unknown position

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

NP_035498.2, NP_001106802.1

ENSEMBL

ENSMUSG00000042626, ENSMUSP00000035361, ENSMUSP00000140336, ENSMUST00000094378, ENSMUST00000039110, ENSMUST00000107417, ENSMUST00000191485, ENSMUSP00000103040, ENSMUSP00000091940

PRO

P98083

MGI

98296

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q60631 Grb2	3	Grb2 [cytosol] (R-MMU-74686) Grb2 [plasma membrane] (R-MMU-202993) Grb2 [cytosol] (R-MMU-443287)	0.899	8
UniProt:Q9JKF1	3	Iqgap1 [plasma membrane] (R-MMU-381681) Iqgap1 [secretory granule membrane] (R-MMU-6804803) Iqgap1 [cytosol] (R-MMU-5626371)	0.65	5
UniProt:P35831	1	PTPN12 [cytosol] (R-MMU-432933)	0.558	2

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