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phospho-Shc1 [cytosol]
Stable Identifier
R-MMU-74684
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
cytosol
Synonyms
p-Y427-SHC1, P98083
Locations in the PathwayBrowser
Expand all
Hemostasis (Mus musculus)
Platelet activation, signaling and aggregation (Mus musculus)
Platelet Aggregation (Plug Formation) (Mus musculus)
Integrin signaling (Mus musculus)
SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow (Mus musculus)
Integrin alpha IIb beta 3:p-Y530-SRC:CSK:Talin:RIAM complex:p-Y427-SHC [plasma membrane] (Mus musculus)
phospho-Shc1 [cytosol] (Mus musculus)
SHC1 dissociates from integrin alphaIIb beta3 (Mus musculus)
Integrin alpha IIb beta 3:p-Y530-SRC:CSK:Talin:RIAM complex:p-Y427-SHC [plasma membrane] (Mus musculus)
phospho-Shc1 [cytosol] (Mus musculus)
phospho-Shc1 [cytosol] (Mus musculus)
Signal Transduction (Mus musculus)
Integrin signaling (Mus musculus)
SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow (Mus musculus)
Integrin alpha IIb beta 3:p-Y530-SRC:CSK:Talin:RIAM complex:p-Y427-SHC [plasma membrane] (Mus musculus)
phospho-Shc1 [cytosol] (Mus musculus)
SHC1 dissociates from integrin alphaIIb beta3 (Mus musculus)
Integrin alpha IIb beta 3:p-Y530-SRC:CSK:Talin:RIAM complex:p-Y427-SHC [plasma membrane] (Mus musculus)
phospho-Shc1 [cytosol] (Mus musculus)
phospho-Shc1 [cytosol] (Mus musculus)
MAPK family signaling cascades (Mus musculus)
MAPK1/MAPK3 signaling (Mus musculus)
RAF/MAP kinase cascade (Mus musculus)
RAS GEFs promote RAS nucleotide exchange (Mus musculus)
RAS GEFs [plasma membrane] (Mus musculus)
GRB2-1:SOS1:p-Y427-SHC1 [cytosol] (Mus musculus)
phospho-Shc1 [cytosol] (Mus musculus)
Signaling by Receptor Tyrosine Kinases (Mus musculus)
Signaling by Insulin receptor (Mus musculus)
Insulin receptor signalling cascade (Mus musculus)
Dissociation of p-Y427-SHC1 from insulin receptor (Mus musculus)
Insulin:p-6Y-Insulin receptor:p-Y427-SHC1 [plasma membrane] (Mus musculus)
phospho-Shc1 [cytosol] (Mus musculus)
phospho-Shc1 [cytosol] (Mus musculus)
GRB2-1:SOS1 binds p-Y427-SHC1 (Mus musculus)
GRB2-1:SOS1:p-Y427-SHC1 [cytosol] (Mus musculus)
phospho-Shc1 [cytosol] (Mus musculus)
phospho-Shc1 [cytosol] (Mus musculus)
Phosphorylation of SHC1 (Mus musculus)
Insulin:p-6Y-Insulin receptor:p-Y427-SHC1 [plasma membrane] (Mus musculus)
phospho-Shc1 [cytosol] (Mus musculus)
Signal attenuation (Mus musculus)
GRB2-1:p-4S-SOS1:p-Y427-SHC1 dissociates (Mus musculus)
GRB2-1:p-4S-SOS1:p-Y427-SHC1 [cytosol] (Mus musculus)
phospho-Shc1 [cytosol] (Mus musculus)
phospho-Shc1 [cytosol] (Mus musculus)
MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y427-SHC1 (Mus musculus)
GRB2-1:SOS1:p-Y427-SHC1 [cytosol] (Mus musculus)
phospho-Shc1 [cytosol] (Mus musculus)
GRB2-1:p-4S-SOS1:p-Y427-SHC1 [cytosol] (Mus musculus)
phospho-Shc1 [cytosol] (Mus musculus)
External Reference Information
External Reference
UniProt:P98083 Shc1
Gene Names
Shc1, Shc, ShcA
Chain
chain:1-579
Reference Genes
BioGPS Gene:20416 Shc1
ENSEMBL:ENSMUSG00000042626 Shc1
KEGG Gene (Mus musculus):20416 Shc1
Monarch:20416 Shc1
NCBI Gene:20416 Shc1
UCSC:P98083 Shc1
Reference Transcript
RefSeq:NM_001113331.2 Shc1
RefSeq:NM_011368.5 Shc1
Other Identifiers
104350_at
10493519
10493530
1422853_at
1422854_at
17399432
17399451
20416
4438479
4464752
4597304
4598666
4611903
4781818
4827703
4831049
4843718
4861442
4866348
4978968
5006563
5040489
5077328
5114887
5151032
5151355
5162067
5230211
5234716
5239308
5244996
5279142
5294395
5334342
5347788
5365949
5475784
5525559
5561997
5567359
93713_at
A_52_P384250
A_55_P1979082
GE41902
GO:0001525
GO:0001784
GO:0003012
GO:0003013
GO:0005154
GO:0005158
GO:0005159
GO:0005168
GO:0005515
GO:0005622
GO:0005634
GO:0005737
GO:0005739
GO:0005759
GO:0005768
GO:0005829
GO:0005886
GO:0006351
GO:0006355
GO:0006940
GO:0007010
GO:0007155
GO:0007165
GO:0007169
GO:0007173
GO:0007507
GO:0007568
GO:0008284
GO:0008286
GO:0010008
GO:0012501
GO:0016525
GO:0019901
GO:0023052
GO:0030036
GO:0030154
GO:0030182
GO:0030971
GO:0031175
GO:0031410
GO:0031532
GO:0032991
GO:0035556
GO:0042127
GO:0042742
GO:0042802
GO:0043066
GO:0043226
GO:0043410
GO:0044877
GO:0045892
GO:0045893
GO:0045907
GO:0046875
GO:0048408
GO:0048661
GO:0048856
GO:0051219
GO:0051721
GO:0070374
GO:0070435
GO:0071363
GO:0071864
GO:0090322
GO:0098542
GO:0098609
GO:1990839
ILMN_1236765
ILMN_2637676
ILMN_2716426
ILMN_2957070
Msa.1387.0_s_at
aa119070_s_at
mMC021453
mMC025703
mMR029196
Participates
as an output of
SHC1 dissociates from integrin alphaIIb beta3 (Mus musculus)
GRB2-1:p-4S-SOS1:p-Y427-SHC1 dissociates (Mus musculus)
Dissociation of p-Y427-SHC1 from insulin receptor (Mus musculus)
as a component of
Integrin alpha IIb beta 3:p-Y530-SRC:CSK:Talin:RIAM complex:p-Y427-SHC [plasma membrane] (Mus musculus)
GRB2-1:p-4S-SOS1:p-Y427-SHC1 [cytosol] (Mus musculus)
Insulin:p-6Y-Insulin receptor:p-Y427-SHC1 [plasma membrane] (Mus musculus)
GRB2-1:SOS1:p-Y427-SHC1 [cytosol] (Mus musculus)
as an input of
GRB2-1:SOS1 binds p-Y427-SHC1 (Mus musculus)
Other forms of this molecule
Shc1 [plasma membrane]
Shc1 [plasma membrane]
Shc1 [plasma membrane]
p-Y-Shc1 [cytosol]
phospho-Shc1 [cytosol]
phospho-Shc1 [cytosol]
phospho-Shc1 [cytosol]
phospho-Shc1 [plasma membrane]
phospho-Shc1 [plasma membrane]
phospho-Shc1 [cytosol]
phospho-Shc1 [cytosol]
phospho-Shc1 [cytosol]
Shc1 [cytosol]
Shc1 [cytosol]
Shc1 [cytosol]
Shc1 [cytosol]
phospho-Shc1 [cytosol]
phospho-Shc1 [cytosol]
Inferred From
p-Y427-SHC1 [cytosol]
(Homo sapiens)
Modified Residues
Name
O4'-phospho-L-tyrosine at 427 (in Homo sapiens)
Coordinate
427
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
NP_035498.2
,
NP_001106802.1
Ensembl
ENSMUSG00000042626
,
ENSMUSP00000140336
,
ENSMUST00000039110
,
ENSMUSP00000035361
,
ENSMUST00000107417
,
ENSMUSP00000091940
,
ENSMUSP00000103040
,
ENSMUST00000094378
,
ENSMUST00000191485
PRO
P98083
MGI
98296
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q60631 Grb2
3
Grb2 [cytosol]
(R-MMU-74686)
Grb2 [plasma membrane]
(R-MMU-202993)
Grb2 [cytosol]
(R-MMU-443287)
0.899
8
UniProt:Q9JKF1
3
Iqgap1 [plasma membrane]
(R-MMU-381681)
Iqgap1 [secretory granule membrane]
(R-MMU-6804803)
Iqgap1 [cytosol]
(R-MMU-5626371)
0.65
5
UniProt:P35831
1
PTPN12 [cytosol]
(R-MMU-432933)
0.558
2
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