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Shc1 [cytosol]
Stable Identifier
R-MMU-74680
Type
Genes and Transcripts [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
cytosol
Synonyms
SHC1, P98083
Locations in the PathwayBrowser
Expand all
Developmental Biology (Mus musculus)
Nervous system development (Mus musculus)
Axon guidance (Mus musculus)
RET signaling (Mus musculus)
2x p-5Y-RET:GDNF:GFRA complexes bind SHC1 (Mus musculus)
2x p-5Y-RET:GDNF:GFRA complexes:SHC1 [plasma membrane] (Mus musculus)
Shc1 [cytosol] (Mus musculus)
Shc1 [cytosol] (Mus musculus)
SHC1 in the RET complex is phosphorylated (Mus musculus)
2x p-5Y-RET:GDNF:GFRA complexes:SHC1 [plasma membrane] (Mus musculus)
Shc1 [cytosol] (Mus musculus)
Hemostasis (Mus musculus)
Cell surface interactions at the vascular wall (Mus musculus)
Tie2 Signaling (Mus musculus)
Interaction of Tie2 and Shc1 (Mus musculus)
ANGPT1:p-5Y,S119-TEK:SHC1 [plasma membrane] (Mus musculus)
Shc1 [cytosol] (Mus musculus)
Shc1 [cytosol] (Mus musculus)
Platelet activation, signaling and aggregation (Mus musculus)
Platelet Aggregation (Plug Formation) (Mus musculus)
Integrin signaling (Mus musculus)
Activated integrin alphaIIb beta3 binds SHC1 (Mus musculus)
Integrin alphaIIb beta 3:p(Y530)-SRC:CSK:Talin:RIAM complex:SHC [plasma membrane] (Mus musculus)
Shc1 [cytosol] (Mus musculus)
Shc1 [cytosol] (Mus musculus)
SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow (Mus musculus)
Integrin alphaIIb beta 3:p(Y530)-SRC:CSK:Talin:RIAM complex:SHC [plasma membrane] (Mus musculus)
Shc1 [cytosol] (Mus musculus)
Immune System (Mus musculus)
Cytokine Signaling in Immune system (Mus musculus)
Signaling by Interleukins (Mus musculus)
Interleukin-2 family signaling (Mus musculus)
Interleukin-2 signaling (Mus musculus)
Phosphorylation of IL2RB Y338 enables SHC recruitment (Mus musculus)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:SHC [plasma membrane] (Mus musculus)
Shc1 [cytosol] (Mus musculus)
Shc1 [cytosol] (Mus musculus)
SHC1 bound to IL2 receptor is phosphorylated (Mus musculus)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:SHC [plasma membrane] (Mus musculus)
Shc1 [cytosol] (Mus musculus)
Interleukin-3, Interleukin-5 and GM-CSF signaling (Mus musculus)
Recruitment of SHC1 is mediated by Y593 of the common beta chain (Mus musculus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)-Bc:SHC1 [plasma membrane] (Mus musculus)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:SHC1 [plasma membrane] (Mus musculus)
Shc1 [cytosol] (Mus musculus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:SHC1 [plasma membrane] (Mus musculus)
Shc1 [cytosol] (Mus musculus)
IL3:IL3R active complex, inactive JAK2, phosphorylated Bc:SHC1 [plasma membrane] (Mus musculus)
Shc1 [cytosol] (Mus musculus)
Shc1 [cytosol] (Mus musculus)
Signal Transduction (Mus musculus)
Integrin signaling (Mus musculus)
Activated integrin alphaIIb beta3 binds SHC1 (Mus musculus)
Integrin alphaIIb beta 3:p(Y530)-SRC:CSK:Talin:RIAM complex:SHC [plasma membrane] (Mus musculus)
Shc1 [cytosol] (Mus musculus)
Shc1 [cytosol] (Mus musculus)
SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow (Mus musculus)
Integrin alphaIIb beta 3:p(Y530)-SRC:CSK:Talin:RIAM complex:SHC [plasma membrane] (Mus musculus)
Shc1 [cytosol] (Mus musculus)
Signaling by Nuclear Receptors (Mus musculus)
ESR-mediated signaling (Mus musculus)
Extra-nuclear estrogen signaling (Mus musculus)
Estrogen receptor binds IGF1R and SHC1 in response to estrogen (Mus musculus)
ESTG:ESR1:p-3Y-IGF1R:SHC1 [plasma membrane] (Mus musculus)
Shc1 [cytosol] (Mus musculus)
Shc1 [cytosol] (Mus musculus)
MMPs cleave HB-EGF (Mus musculus)
ESTG:ESR1:p-3Y-IGF1R:SHC1 [plasma membrane] (Mus musculus)
Shc1 [cytosol] (Mus musculus)
Signaling by Receptor Tyrosine Kinases (Mus musculus)
Signaling by EGFR (Mus musculus)
SHC1 events in EGFR signaling (Mus musculus)
SHC1 binds to the phosphorylated EGF receptor:ligand complex (Mus musculus)
EGF-like ligands:p-6Y EGFR:SHC1 [plasma membrane] (Mus musculus)
Shc1 [cytosol] (Mus musculus)
Shc1 [cytosol] (Mus musculus)
SHC1 phosphorylation by phosphorylated EGFR (Mus musculus)
EGF-like ligands:p-6Y EGFR:SHC1 [plasma membrane] (Mus musculus)
Shc1 [cytosol] (Mus musculus)
Signaling by ERBB2 (Mus musculus)
SHC1 events in ERBB2 signaling (Mus musculus)
SHC1 phosphorylation by ERBB2 heterodimers (Mus musculus)
SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane] (Mus musculus)
Shc1 [cytosol] (Mus musculus)
Signaling by ERBB4 (Mus musculus)
SHC1 events in ERBB4 signaling (Mus musculus)
Phosphorylation of SHC1 by ERBB4 homodimers (Mus musculus)
SHC1:p-ERBB4 [plasma membrane] (Mus musculus)
Shc1 [cytosol] (Mus musculus)
SHC1 binds P-ERBB4 isoform dimers (Mus musculus)
SHC1:p-ERBB4 [plasma membrane] (Mus musculus)
Shc1 [cytosol] (Mus musculus)
Shc1 [cytosol] (Mus musculus)
Signaling by Insulin receptor (Mus musculus)
Insulin receptor signalling cascade (Mus musculus)
Binding of SHC1 to insulin receptor (Mus musculus)
Insulin:p-6Y-Insulin receptor:SHC1 [plasma membrane] (Mus musculus)
Shc1 [cytosol] (Mus musculus)
Shc1 [cytosol] (Mus musculus)
Phosphorylation of SHC1 (Mus musculus)
Insulin:p-6Y-Insulin receptor:SHC1 [plasma membrane] (Mus musculus)
Shc1 [cytosol] (Mus musculus)
Signaling by LTK (Mus musculus)
Active LTK receptor binds SHC1 (Mus musculus)
Active LTK:SHC1 [plasma membrane] (Mus musculus)
SHC1-1,SHC1-2,SHC1-3 [cytosol] (Mus musculus)
Shc1 [cytosol] (Mus musculus)
SHC1-1,SHC1-2,SHC1-3 [cytosol] (Mus musculus)
Shc1 [cytosol] (Mus musculus)
Active LTK receptor phosphorylates SHC1 (Mus musculus)
Active LTK:SHC1 [plasma membrane] (Mus musculus)
SHC1-1,SHC1-2,SHC1-3 [cytosol] (Mus musculus)
Shc1 [cytosol] (Mus musculus)
External Reference Information
External Reference
UniProt:P98083-3 Shc1
Gene Names
Shc1, Shc, ShcA
Other Identifiers
104350_at
10493519
10493530
1422853_at
1422854_at
17399432
17399451
20416
4438479
4464752
4597304
4598666
4611903
4781818
4827703
4831049
4843718
4861442
4866348
4978968
5006563
5040489
5077328
5114887
5151032
5151355
5162067
5230211
5234716
5239308
5244996
5279142
5294395
5334342
5347788
5365949
5475784
5525559
5561997
5567359
93713_at
A_52_P384250
A_55_P1979082
A_65_P17586
GE41902
GO:0001525
GO:0001784
GO:0003012
GO:0003013
GO:0005068
GO:0005154
GO:0005158
GO:0005159
GO:0005168
GO:0005515
GO:0005737
GO:0005739
GO:0005759
GO:0005768
GO:0005829
GO:0005886
GO:0005925
GO:0006351
GO:0006355
GO:0006940
GO:0007010
GO:0007155
GO:0007173
GO:0007507
GO:0008284
GO:0008286
GO:0010008
GO:0012501
GO:0016525
GO:0023052
GO:0030036
GO:0030154
GO:0030182
GO:0030971
GO:0031175
GO:0031410
GO:0035556
GO:0042127
GO:0042742
GO:0043066
GO:0043226
GO:0043410
GO:0044877
GO:0045892
GO:0045893
GO:0045907
GO:0046875
GO:0048009
GO:0048408
GO:0048661
GO:0048856
GO:0051219
GO:0051721
GO:0060090
GO:0070161
GO:0070374
GO:0070435
GO:0071363
GO:0071864
GO:0090322
GO:0098542
GO:0098609
GO:1990839
ILMN_1236765
ILMN_2637676
ILMN_2716426
ILMN_2957070
Msa.1387.0_s_at
aa119070_s_at
mMC021453
mMC025703
mMR029196
Participates
as an input of
Activated integrin alphaIIb beta3 binds SHC1 (Mus musculus)
Estrogen receptor binds IGF1R and SHC1 in response to estrogen (Mus musculus)
Interaction of Tie2 and Shc1 (Mus musculus)
Binding of SHC1 to insulin receptor (Mus musculus)
Recruitment of SHC1 is mediated by Y593 of the common beta chain (Mus musculus)
Phosphorylation of IL2RB Y338 enables SHC recruitment (Mus musculus)
2x p-5Y-RET:GDNF:GFRA complexes bind SHC1 (Mus musculus)
SHC1 binds P-ERBB4 isoform dimers (Mus musculus)
SHC1 binds to the phosphorylated EGF receptor:ligand complex (Mus musculus)
as a component of
Integrin alphaIIb beta 3:p(Y530)-SRC:CSK:Talin:RIAM complex:SHC [plasma membrane] (Mus musculus)
ESTG:ESR1:p-3Y-IGF1R:SHC1 [plasma membrane] (Mus musculus)
ANGPT1:p-5Y,S119-TEK:SHC1 [plasma membrane] (Mus musculus)
Insulin:p-6Y-Insulin receptor:SHC1 [plasma membrane] (Mus musculus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:SHC1 [plasma membrane] (Mus musculus)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:SHC1 [plasma membrane] (Mus musculus)
IL3:IL3R active complex, inactive JAK2, phosphorylated Bc:SHC1 [plasma membrane] (Mus musculus)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:SHC [plasma membrane] (Mus musculus)
SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane] (Mus musculus)
2x p-5Y-RET:GDNF:GFRA complexes:SHC1 [plasma membrane] (Mus musculus)
SHC1:p-ERBB4 [plasma membrane] (Mus musculus)
EGF-like ligands:p-6Y EGFR:SHC1 [plasma membrane] (Mus musculus)
as a candidate of
SHC1-1,SHC1-2,SHC1-3 [cytosol] (Mus musculus)
Other forms of this molecule
p-Y-Shc1-3 [cytosol]
Shc1-3 [cytosol]
Shc1 [plasma membrane]
Shc1 [plasma membrane]
Shc1 [plasma membrane]
phospho-Shc1 [cytosol]
phospho-Shc1 [cytosol]
phospho-Shc1 [cytosol]
phospho-Shc1 [plasma membrane]
phospho-Shc1 [plasma membrane]
phospho-Shc1 [cytosol]
phospho-Shc1 [cytosol]
phospho-Shc1 [cytosol]
phospho-Shc1 [cytosol]
Shc1 [cytosol]
Shc1 [cytosol]
phospho-Shc1 [cytosol]
phospho-Shc1 [cytosol]
Inferred From
SHC1 [cytosol]
(Homo sapiens)
SHC1-1 [cytosol]
(Homo sapiens)
SHC1 [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_035498.2
,
NP_001106802.1
Ensembl
ENSMUST00000039110
,
ENSMUSG00000042626
,
ENSMUSP00000091940
,
ENSMUSP00000140336
,
ENSMUSP00000035361
,
ENSMUST00000191485
,
ENSMUSP00000103040
,
ENSMUST00000107417
,
ENSMUST00000094378
PRO
P98083
MGI
98296
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q60631 Grb2
1
Grb2 [cytosol]
(R-MMU-443287)
0.899
8
UniProt:Q9JKF1
3
Iqgap1 [plasma membrane]
(R-MMU-381681)
Iqgap1 [secretory granule membrane]
(R-MMU-6804803)
Iqgap1 [cytosol]
(R-MMU-5626371)
0.65
5
UniProt:P35831
1
PTPN12 [cytosol]
(R-MMU-432933)
0.558
2
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