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phospho-p-S272,T222,T334-MAPKAPK2 [cytosol]
Stable Identifier
R-MMU-187760
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
cytosol
Synonyms
P49138
Locations in the PathwayBrowser
Expand all
Immune System (Mus musculus)
Cytokine Signaling in Immune system (Mus musculus)
Signaling by Interleukins (Mus musculus)
Interleukin-17 signaling (Mus musculus)
MAP kinase activation (Mus musculus)
activated TAK1 mediates p38 MAPK activation (Mus musculus)
Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3 (Mus musculus)
p-p38 MAPK: p-S272,T222,T334-MAPKAPK2, p-S,2T-MAPKAPK3 [cytosol] (Mus musculus)
p-S272,T222,T334-MAPKAPK2, p-S,2T-MAPKAPK3 [cytosol] (Mus musculus)
phospho-p-S272,T222,T334-MAPKAPK2 [cytosol] (Mus musculus)
Innate Immune System (Mus musculus)
Toll-like Receptor Cascades (Mus musculus)
Toll Like Receptor 10 (TLR10) Cascade (Mus musculus)
MyD88 cascade initiated on plasma membrane (Mus musculus)
MAP kinase activation (Mus musculus)
activated TAK1 mediates p38 MAPK activation (Mus musculus)
Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3 (Mus musculus)
p-p38 MAPK: p-S272,T222,T334-MAPKAPK2, p-S,2T-MAPKAPK3 [cytosol] (Mus musculus)
p-S272,T222,T334-MAPKAPK2, p-S,2T-MAPKAPK3 [cytosol] (Mus musculus)
phospho-p-S272,T222,T334-MAPKAPK2 [cytosol] (Mus musculus)
Toll Like Receptor 2 (TLR2) Cascade (Mus musculus)
Toll Like Receptor TLR1:TLR2 Cascade (Mus musculus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Mus musculus)
MAP kinase activation (Mus musculus)
activated TAK1 mediates p38 MAPK activation (Mus musculus)
Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3 (Mus musculus)
p-p38 MAPK: p-S272,T222,T334-MAPKAPK2, p-S,2T-MAPKAPK3 [cytosol] (Mus musculus)
p-S272,T222,T334-MAPKAPK2, p-S,2T-MAPKAPK3 [cytosol] (Mus musculus)
phospho-p-S272,T222,T334-MAPKAPK2 [cytosol] (Mus musculus)
Toll Like Receptor TLR6:TLR2 Cascade (Mus musculus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Mus musculus)
MAP kinase activation (Mus musculus)
activated TAK1 mediates p38 MAPK activation (Mus musculus)
Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3 (Mus musculus)
p-p38 MAPK: p-S272,T222,T334-MAPKAPK2, p-S,2T-MAPKAPK3 [cytosol] (Mus musculus)
p-S272,T222,T334-MAPKAPK2, p-S,2T-MAPKAPK3 [cytosol] (Mus musculus)
phospho-p-S272,T222,T334-MAPKAPK2 [cytosol] (Mus musculus)
Toll Like Receptor 3 (TLR3) Cascade (Mus musculus)
MAP kinase activation (Mus musculus)
activated TAK1 mediates p38 MAPK activation (Mus musculus)
Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3 (Mus musculus)
p-p38 MAPK: p-S272,T222,T334-MAPKAPK2, p-S,2T-MAPKAPK3 [cytosol] (Mus musculus)
p-S272,T222,T334-MAPKAPK2, p-S,2T-MAPKAPK3 [cytosol] (Mus musculus)
phospho-p-S272,T222,T334-MAPKAPK2 [cytosol] (Mus musculus)
Toll Like Receptor 4 (TLR4) Cascade (Mus musculus)
MyD88-independent TLR4 cascade (Mus musculus)
TRIF (TICAM1)-mediated TLR4 signaling (Mus musculus)
MAP kinase activation (Mus musculus)
activated TAK1 mediates p38 MAPK activation (Mus musculus)
Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3 (Mus musculus)
p-p38 MAPK: p-S272,T222,T334-MAPKAPK2, p-S,2T-MAPKAPK3 [cytosol] (Mus musculus)
p-S272,T222,T334-MAPKAPK2, p-S,2T-MAPKAPK3 [cytosol] (Mus musculus)
phospho-p-S272,T222,T334-MAPKAPK2 [cytosol] (Mus musculus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Mus musculus)
MAP kinase activation (Mus musculus)
activated TAK1 mediates p38 MAPK activation (Mus musculus)
Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3 (Mus musculus)
p-p38 MAPK: p-S272,T222,T334-MAPKAPK2, p-S,2T-MAPKAPK3 [cytosol] (Mus musculus)
p-S272,T222,T334-MAPKAPK2, p-S,2T-MAPKAPK3 [cytosol] (Mus musculus)
phospho-p-S272,T222,T334-MAPKAPK2 [cytosol] (Mus musculus)
Toll Like Receptor 5 (TLR5) Cascade (Mus musculus)
MyD88 cascade initiated on plasma membrane (Mus musculus)
MAP kinase activation (Mus musculus)
activated TAK1 mediates p38 MAPK activation (Mus musculus)
Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3 (Mus musculus)
p-p38 MAPK: p-S272,T222,T334-MAPKAPK2, p-S,2T-MAPKAPK3 [cytosol] (Mus musculus)
p-S272,T222,T334-MAPKAPK2, p-S,2T-MAPKAPK3 [cytosol] (Mus musculus)
phospho-p-S272,T222,T334-MAPKAPK2 [cytosol] (Mus musculus)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Mus musculus)
MyD88 dependent cascade initiated on endosome (Mus musculus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Mus musculus)
MAP kinase activation (Mus musculus)
activated TAK1 mediates p38 MAPK activation (Mus musculus)
Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3 (Mus musculus)
p-p38 MAPK: p-S272,T222,T334-MAPKAPK2, p-S,2T-MAPKAPK3 [cytosol] (Mus musculus)
p-S272,T222,T334-MAPKAPK2, p-S,2T-MAPKAPK3 [cytosol] (Mus musculus)
phospho-p-S272,T222,T334-MAPKAPK2 [cytosol] (Mus musculus)
Toll Like Receptor 9 (TLR9) Cascade (Mus musculus)
MyD88 dependent cascade initiated on endosome (Mus musculus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Mus musculus)
MAP kinase activation (Mus musculus)
activated TAK1 mediates p38 MAPK activation (Mus musculus)
Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3 (Mus musculus)
p-p38 MAPK: p-S272,T222,T334-MAPKAPK2, p-S,2T-MAPKAPK3 [cytosol] (Mus musculus)
p-S272,T222,T334-MAPKAPK2, p-S,2T-MAPKAPK3 [cytosol] (Mus musculus)
phospho-p-S272,T222,T334-MAPKAPK2 [cytosol] (Mus musculus)
Metabolism (Mus musculus)
Metabolism of lipids (Mus musculus)
Fatty acid metabolism (Mus musculus)
Arachidonic acid metabolism (Mus musculus)
Synthesis of Leukotrienes (LT) and Eoxins (EX) (Mus musculus)
ALOX5 is phosphorylated by MAPKAP2 (Mus musculus)
phospho-p-S272,T222,T334-MAPKAPK2 [cytosol] (Mus musculus)
Metabolism of RNA (Mus musculus)
Regulation of mRNA stability by proteins that bind AU-rich elements (Mus musculus)
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA (Mus musculus)
MK2 phosphorylates BRF1 (Mus musculus)
phospho-p-S272,T222,T334-MAPKAPK2 [cytosol] (Mus musculus)
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA (Mus musculus)
MK2 phosphorylates ZFP36 (Tristetraproline, TTP) (Mus musculus)
phospho-p-S272,T222,T334-MAPKAPK2 [cytosol] (Mus musculus)
Signal Transduction (Mus musculus)
Death Receptor Signaling (Mus musculus)
TNF signaling (Mus musculus)
Regulation of TNFR1 signaling (Mus musculus)
MAPKAPK2 phosphorylates RIPK1 at S320 (Mus musculus)
phospho-p-S272,T222,T334-MAPKAPK2 [cytosol] (Mus musculus)
Signaling by Receptor Tyrosine Kinases (Mus musculus)
Signaling by NTRKs (Mus musculus)
Signaling by NTRK1 (TRKA) (Mus musculus)
Signalling to ERKs (Mus musculus)
Signalling to RAS (Mus musculus)
p38MAPK events (Mus musculus)
p38 MAPK phosphorylates MAPKAPK2, MAPKAPK3 (Mus musculus)
p-S272,T222,T334-MAPKAPK2, p-S,2T-MAPKAPK3 [cytosol] (Mus musculus)
phospho-p-S272,T222,T334-MAPKAPK2 [cytosol] (Mus musculus)
Signaling by VEGF (Mus musculus)
VEGFA-VEGFR2 Pathway (Mus musculus)
p-MAPK2/3 phosphorylates HSP27 (Mus musculus)
p-S272,T222,T334-MAPKAPK2, p-S,2T-MAPKAPK3 [cytosol] (Mus musculus)
phospho-p-S272,T222,T334-MAPKAPK2 [cytosol] (Mus musculus)
p38 MAPK phosphorylates MAPKAPK2, MAPKAPK3 (Mus musculus)
p-S272,T222,T334-MAPKAPK2, p-S,2T-MAPKAPK3 [cytosol] (Mus musculus)
phospho-p-S272,T222,T334-MAPKAPK2 [cytosol] (Mus musculus)
External Reference Information
External Reference
UniProt:P49138
Reference Genes
BioGPS Gene:17164
ENSEMBL:ENSMUSG00000016528
ENSEMBL:ENSMUSG00000016528.11
KEGG Gene (Mus musculus):17164
Monarch:17164
NCBI Gene:17164
UCSC:P49138
Reference Transcript
RefSeq:NM_008551.2
Other Identifiers
10357579
1426648_at
160353_i_at
17164
17226736
4340537
4372165
4384092
4415410
4512547
4528383
4700723
4703528
4803257
4894042
4915900
4942562
4996842
5100483
5151492
5169050
5191394
5367325
5402893
5497643
5516612
95721_at
A_51_P118902
A_52_P15008
GE113759
GE33074
GO:0000166
GO:0002224
GO:0002376
GO:0003824
GO:0004672
GO:0004674
GO:0004683
GO:0005515
GO:0005516
GO:0005524
GO:0005634
GO:0005654
GO:0005737
GO:0005813
GO:0005815
GO:0005856
GO:0006468
GO:0006954
GO:0006974
GO:0009931
GO:0016071
GO:0016192
GO:0016301
GO:0016310
GO:0016740
GO:0023052
GO:0032496
GO:0032675
GO:0032680
GO:0032760
GO:0034097
GO:0035556
GO:0035924
GO:0036211
GO:0038066
GO:0043226
GO:0044351
GO:0048010
GO:0048255
GO:0048839
GO:0048856
GO:0050896
GO:0051019
GO:0060907
GO:0070935
GO:0098542
GO:0106310
GO:0140096
ILMN_2614212
Msa.2435.0_r_at
Msa.2435.0_s_at
mMC002462
Participates
as a member of
p-S272,T222,T334-MAPKAPK2, p-S,2T-MAPKAPK3 [cytosol] (Mus musculus)
Other forms of this molecule
MAPKAPK2 [cytosol]
phospho-p-T222,S272-MAPKAPK2 [nucleoplasm]
phospho-p-T222,S272,T334-MAPKAPK2 [nucleoplasm]
MAPKAPK2 [nucleoplasm]
Inferred From
p-S272,T222,T334-MAPKAPK2 [cytosol]
(Homo sapiens)
Modified Residues
Name
O-phospho-L-threonine at 222 (in Homo sapiens)
Coordinate
222
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O-phospho-L-serine at 272 (in Homo sapiens)
Coordinate
272
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-threonine at 334 (in Homo sapiens)
Coordinate
334
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Cross References
RefSeq
NP_032577.1
IntEnz
2.7.11.1
ZINC - Substances
MAPK2_MOUSE
ZINC target
P49138
Ensembl
ENSMUST00000016672
,
ENSMUSG00000016528
,
ENSMUSP00000016672
PRO
P49138
MGI
109298
ZINC - Predictions - Purchasable
MAPK2_MOUSE
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9QWH1
1
PHC2 [nucleoplasm]
(R-MMU-389112)
0.611
5
UniProt:P47811 Mapk14
7
MAPK14 [secretory granule lumen]
(R-MMU-6803300)
MAPK14 [extracellular region]
(R-MMU-6806453)
MAPK14 [ficolin-1-rich granule lumen]
(R-MMU-6803280)
MAPK14 [nucleoplasm]
(R-MMU-446223)
MAP kinase p38 alpha [cytosol]
(R-MMU-448843)
phospho-MAP kinase p38 alpha [cytosol]
(R-MMU-448842)
p-T180,Y182-Mapk14 [nucleoplasm]
(R-MMU-1605486)
0.527
2
UniProt:Q64028
1
PHC1 [nucleoplasm]
(R-MMU-389111)
0.527
2
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