Reactome | pFyn(Y531) [cytosol]

pFyn(Y531) [cytosol]

Stable Identifier

R-MMU-420350

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

External Reference Information

External Reference

UniProt:P39688 Fyn

Gene Names

Fyn

Chain

initiator methionine:, chain:2-537

Reference Genes

BioGPS Gene:14360 Fyn

ENSEMBL:ENSMUSG00000019843.15 Fyn

KEGG Gene (Mus musculus):14360 Fyn

Monarch:14360 Fyn

NCBI Gene:14360 Fyn

UCSC:P39688 Fyn

Reference Transcript

Other Identifiers

100133_at

10362596

1417558_at

14360

1448765_at

17232649

4314829

4397041

4466414

4541435

4580322

4654065

4676338

4715314

4725505

4743495

4781355

4858624

4940270

4945244

4963615

5066773

5108731

5151999

5281641

5312172

5529442

5554180

5559307

A_66_P138915

GO:0000166

GO:0000304

GO:0001664

GO:0001764

GO:0002250

GO:0002376

GO:0003013

GO:0003015

GO:0003824

GO:0004672

GO:0004713

GO:0004715

GO:0005102

GO:0005515

GO:0005524

GO:0005634

GO:0005737

GO:0005739

GO:0005768

GO:0005783

GO:0005829

GO:0005856

GO:0005884

GO:0005886

GO:0006468

GO:0006886

GO:0007166

GO:0007169

GO:0008092

GO:0008360

GO:0010629

GO:0010730

GO:0010976

GO:0012501

GO:0014069

GO:0015631

GO:0016004

GO:0016020

GO:0016301

GO:0016310

GO:0016567

GO:0016740

GO:0018108

GO:0019899

GO:0023052

GO:0030154

GO:0030163

GO:0030425

GO:0030900

GO:0031175

GO:0031234

GO:0031397

GO:0031410

GO:0031802

GO:0034330

GO:0035556

GO:0036120

GO:0036211

GO:0042177

GO:0042531

GO:0042552

GO:0042608

GO:0042609

GO:0042610

GO:0042802

GO:0043014

GO:0043204

GO:0043226

GO:0043274

GO:0043524

GO:0043548

GO:0044297

GO:0044325

GO:0044877

GO:0045087

GO:0045121

GO:0045471

GO:0046872

GO:0046875

GO:0048156

GO:0048471

GO:0048813

GO:0048856

GO:0048870

GO:0050730

GO:0050798

GO:0050804

GO:0050852

GO:0050877

GO:0050966

GO:0051428

GO:0051897

GO:0055085

GO:0070301

GO:0070851

GO:0071560

GO:0071944

GO:0090314

GO:0097038

GO:0097110

GO:0097386

GO:0097718

GO:0098542

GO:0098685

GO:0098772

GO:0098978

GO:0099092

GO:0140096

GO:1900182

GO:1900449

GO:1902176

GO:1902951

GO:1904645

GO:1904646

GO:1905232

GO:1905430

GO:1905664

GO:2001240

ILMN_2663821

ILMN_2730490

ILMN_2751207

mMC016479

u70324_s_at

Participates

as a component of

as an input of

Fyn binds NCAM1 (Mus musculus)

Other forms of this molecule

Fyn [cytosol]

phospho-MyrG-p-Y420-FYN-1 [plasma membrane]

pFyn (420) [cytosol]

phospho-p-S21,Y420-FYN [cytosol]

MyrG,p-Y420-Fyn [plasma membrane]

Modified Residues

Name

O4'-phospho-L-tyrosine at 531

Coordinate

531

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

XP_011241419.1, XP_006512603.1, NP_001116364.1, NP_032080.2, NP_001116365.1, XP_006512602.1

IntEnz

2.7.10.2

ZINC - Substances

FYN_MOUSE

ZINC target

P39688

Ensembl

ENSMUSP00000114188, ENSMUSG00000019843, ENSMUSP00000115233, ENSMUSP00000097547, ENSMUST00000135242, ENSMUST00000146287, ENSMUSP00000117111, ENSMUST00000099967, ENSMUSP00000057707, ENSMUST00000126486, ENSMUST00000063091

PRO

P39688

ZINC - Predictions - Purchasable

FYN_MOUSE

MGI

95602

PDB

3UF4

Interactors (13)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9QUM4 SLAF1			0.82	15
UniProt:P22681 CBL	20	PolyUb,p-Y-CBL [cytosol] (R-HSA-9763893) CBL R420G [cytosol] (R-HSA-9706203) CBL R420Q [cytosol] (R-HSA-9706186) CBL Y371H [cytosol] (R-HSA-9706680) CBL H398Y [cytosol] (R-HSA-9706639) CBL P417A [cytosol] (R-HSA-9706636) CBL S376F [cytosol] (R-HSA-9706643) CBL E366_Q409del [cytosol] (R-HSA-9706179) CBL del366-477 [cytosol] (R-HSA-9706176) CBL R499L [cytosol] (R-HSA-9706678) CBL L380P [cytosol] (R-HSA-9706630) CBL L287R [cytosol] (R-HSA-9706693) CBL L380R [cytosol] (R-HSA-9706635) CBL G375P [cytosol] (R-HSA-9706219) CBL P417L [cytosol] (R-HSA-9706634) CBL H398Q [cytosol] (R-HSA-9706633) CBL P417R [cytosol] (R-HSA-9706632) CBL R499* [cytosol] (R-HSA-9706670) CBL H398R [cytosol] (R-HSA-9706638) CBL H398P [cytosol] (R-HSA-9706637)	0.591	3
UniProt:Q60749	3	Khdrbs1 [nucleoplasm] (R-MMU-8848941) phospho-Khdrbs1 [cytosol] (R-MMU-8848995) phospho-Khdrbs1 [nucleoplasm] (R-MMU-8848970)	0.573	15
UniProt:P18052	1	PTPRA [plasma membrane] (R-MMU-388755)	0.564	2
UniProt:O88890 SH21A			0.564	4
UniProt:P22682 Cbl	8	Cbl [cytosol] (R-MMU-9680636) p-Y-Cbl [cytosol] (R-MMU-9680645) phospho-p-Y-CBL [cytosol] (R-MMU-8875457) phospho-p-Y371-CBL [cytosol] (R-MMU-182940) phospho-p-Y371-CBL [plasma membrane] (R-MMU-182923) phospho-PolyUb,p-Y700,Y731,Y774-CBL [cytosol] (R-MMU-8848826) phospho-p-Y700,Y731,Y774-CBL [cytosol] (R-MMU-912656) CBL [cytosol] (R-MMU-112199)	0.564	5
UniProt:Q9JIA7	1	SPHK2 [cytosol] (R-MMU-428236)	0.544	2
UniProt:Q14332 FZD2	2	FZD2 [clathrin-coated endocytic vesicle membrane] (R-HSA-5140723) FZD2 [plasma membrane] (R-HSA-443945)	0.525	4
UniProt:P18433 PTPRA	1	PTPRA [plasma membrane] (R-HSA-388755)	0.524	2
UniProt:O75051 PLXNA2	2	PLXNA2 [plasma membrane] (R-HSA-396934) p-Y-PLXNA2 [plasma membrane] (R-HSA-419607)	0.499	3
UniProt:Q3U1F9	2	Pag1 [plasma membrane] (R-MMU-180500) phospho-Pag1 [plasma membrane] (R-MMU-180494)	0.499	4
UniProt:Q9JJG6 TMM47			0.463	2
UniProt:P35570 Irs1	7	Irs1 [cytosol] (R-RNO-1168867) phospho-Irs1 [plasma membrane] (R-RNO-2445090) Irs1 [plasma membrane] (R-RNO-2425392) p-Y-Irs1 [cytosol] (R-RNO-112362) Irs1 [cytosol] (R-RNO-74769) phospho-Irs1 [cytosol] (R-RNO-74772) phospho-Irs1 [plasma membrane] (R-RNO-198366)	0.462	4

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