Reactome | PLXNA2 [plasma membrane]

PLXNA2 [plasma membrane]

Stable Identifier

R-HSA-396934

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Plexin-A2, PLXA2_HUMAN

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External Reference Information

External Reference

UniProt:O75051 PLXNA2

Gene Names

PLXNA2, KIAA0463, OCT, PLXN2, UNQ209/PRO235

Chain

signal peptide:1-34, chain:35-1894

Reference Genes

BioGPS Gene:5362 PLXNA2

COSMIC (genes):PLXNA2 PLXNA2

CTD Gene:5362 PLXNA2

dbSNP Gene:5362 PLXNA2

ENSEMBL:ENSG00000076356 PLXNA2

HGNC:9100 PLXNA2

KEGG:hsa:5362 PLXNA2

Monarch:5362 PLXNA2

NCBI Gene:5362 PLXNA2

OMIM:601054 PLXNA2

UCSC:O75051 PLXNA2

Reference Transcript

RefSeq:NM_025179.3 PLXNA2

Other Identifiers

11720562_a_at

11720563_at

16698816

207290_PM_at

207290_at

213030_PM_s_at

213030_s_at

227032_PM_at

227032_at

2453366

2453367

2453369

2453371

2453372

2453373

2453374

2453375

2453376

2453377

2453378

2453382

2453384

2453387

2453388

2453389

2453390

2453391

2453392

2453393

2453396

2453398

2453399

2453401

2453402

2453403

2453404

2453406

2453413

2453414

2453415

2453419

2453421

2453422

2453424

2453425

2453440

2453451

2453452

2453453

2453454

2453455

2453456

2453457

2453459

2453460

2453463

2453464

40395_at

5362

54877_at

56539_at

7923991

A_23_P307544

A_23_P46618

GE476341

GE53202

GO:0001756

GO:0002116

GO:0005515

GO:0005886

GO:0007162

GO:0007166

GO:0008360

GO:0017154

GO:0021915

GO:0021935

GO:0030334

GO:0042802

GO:0048856

GO:0048870

GO:0050772

GO:0051642

GO:0060037

GO:0060089

GO:0060174

GO:0071526

HMNXSV003002733

HMNXSV003022410

Hs.290927.0.A1_3p_at

Hs.300622.1.S1_3p_a_at

ILMN_1680617

ILMN_1844408

PH_hs_0015467

PH_hs_0032777

TC01003778.hg

TC01006075.hg

g13378152_3p_at

Participates

as a member of

as a component of

Plexin-A2:Neuropilin-1:Fyn [plasma membrane] (Homo sapiens)

Other forms of this molecule

p-Y-PLXNA2 [plasma membrane]

Inferred To

Plxna2 [plasma membrane] (Rattus norvegicus)

plxna2 [plasma membrane] (Danio rerio)

plxna2 [plasma membrane] (Xenopus tropicalis)

PlexA [plasma membrane] (Drosophila melanogaster)

plx-1 [plasma membrane] (Caenorhabditis elegans)

PLXNA2 [plasma membrane] (Bos taurus)

PLXNA2 [plasma membrane] (Gallus gallus)

PLXNA2 [plasma membrane] (Sus scrofa)

Plexin-A2 [plasma membrane] (Mus musculus)

Cross References

ENSEMBL

ENSG00000076356, ENST00000367033, ENSP00000356000

OpenTargets

ENSG00000076356

GeneCards

PLXNA2

HPA

ENSG00000076356-PLXNA2

PRO

O75051

Pharos - Targets

O75051

GlyGen

O75051

PDB

3Q3J

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P59665 DEFA1	9	DEFA1(1-94) [Golgi lumen] (R-HSA-1467215) DEFA1(20-94) [Golgi lumen] (R-HSA-1467282) DEFA1(66-94) [Golgi lumen] (R-HSA-975663) DEFA1(20-65) [Golgi lumen] (R-HSA-8864970) DEFA1(66-94) [extracellular region] (R-HSA-1461998) DEFA1(66-94) [azurophil granule lumen] (R-HSA-1470038) DEFA1(65-94) [extracellular region] (R-HSA-1462022) omega-N-(ADP-ribosyl)-L-arginine-DEFA1(65-94) [extracellular region] (R-HSA-1972397) DEFA1(65-94) [azurophil granule lumen] (R-HSA-1470053)	0.527	2
UniProt:P43630 KIR3DL2	1	KIR3DL2 [plasma membrane] (R-HSA-197713)	0.527	2
UniProt:P01375 TNF	5	TNF(1-233) [plasma membrane] (R-HSA-66220) TNF(77-233) [extracellular region] (R-HSA-976821) TNF(1-76) [plasma membrane] (R-HSA-8863120) TNF(1-34) [plasma membrane] (R-HSA-8863367) TNF(52-76) [extracellular region] (R-HSA-8863375)	0.527	2
UniProt:Q01523 DEFA5	5	DEFA5(1-94) [Golgi lumen] (R-HSA-1467267) DEFA5(20-94) [Golgi lumen] (R-HSA-1467208) DEFA5(20-94) [secretory granule lumen] (R-HSA-1471358) DEFA5(20-94) [extracellular region] (R-HSA-1471344) DEFA5(?-94) [extracellular region] (R-HSA-1462017)	0.527	2
UniProt:P39688 Fyn	6	Fyn [cytosol] (R-MMU-420333) MyrG,p-Y420-Fyn [plasma membrane] (R-MMU-9037733) phospho-p-Y420-FYN [cytosol] (R-MMU-391821) pFyn(Y531) [cytosol] (R-MMU-420350) pFyn (420) [cytosol] (R-MMU-420335) phospho-p-S21,Y420-FYN [cytosol] (R-MMU-5218745)	0.499	3