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PLXNA2 [plasma membrane]
Stable Identifier
R-HSA-396934
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Plexin-A2, PLXA2_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
Semaphorin interactions (Homo sapiens)
CRMPs in Sema3A signaling (Homo sapiens)
Activation of Fyn (Homo sapiens)
NRP1:PlexinA1-4:FYN [plasma membrane] (Homo sapiens)
Plexin-A1-4:FYN [plasma membrane] (Homo sapiens)
Plexin-A1-4 [plasma membrane] (Homo sapiens)
PLXNA2 [plasma membrane] (Homo sapiens)
Sema3A:Nrp-1:PlexinA:Fyn [plasma membrane] (Homo sapiens)
NRP1:PlexinA1-4:FYN [plasma membrane] (Homo sapiens)
Plexin-A1-4:FYN [plasma membrane] (Homo sapiens)
Plexin-A1-4 [plasma membrane] (Homo sapiens)
PLXNA2 [plasma membrane] (Homo sapiens)
Phosphorylation of CRMPs by Cdk5 (Homo sapiens)
Sema3A:Nrp-1:PlexinA:Fyn:Cdk5:pCRMP's [plasma membrane] (Homo sapiens)
NRP1:PlexinA1-4:FYN:Cdk5:p53:p-CRMP tetramers [plasma membrane] (Homo sapiens)
PlexinA1-4:FYN:Cdk5:p35:p-CRMP tetramers [plasma membrane] (Homo sapiens)
Plexin-A1-4 [plasma membrane] (Homo sapiens)
PLXNA2 [plasma membrane] (Homo sapiens)
Sema3A:Nrp-1:PlexinA:Fyn:pCdk5 [plasma membrane] (Homo sapiens)
NRP1:PlexinA1-4:FYN:pCdk5:p53 [plasma membrane] (Homo sapiens)
PlexinA1-4:FYN:pCdk5:p35 [plasma membrane] (Homo sapiens)
Plexin-A1-4 [plasma membrane] (Homo sapiens)
PLXNA2 [plasma membrane] (Homo sapiens)
Phosphorylation of CRMPs by GSK3beta (Homo sapiens)
Sema3A:Nrp-1:PlexinA:Fyn:Cdk5:pCRMP's [plasma membrane] (Homo sapiens)
NRP1:PlexinA1-4:FYN:Cdk5:p53:p-CRMP tetramers [plasma membrane] (Homo sapiens)
PlexinA1-4:FYN:Cdk5:p35:p-CRMP tetramers [plasma membrane] (Homo sapiens)
Plexin-A1-4 [plasma membrane] (Homo sapiens)
PLXNA2 [plasma membrane] (Homo sapiens)
Recruitment and activation of Cdk5 (Homo sapiens)
Sema3A:Nrp-1:PlexinA:Fyn [plasma membrane] (Homo sapiens)
NRP1:PlexinA1-4:FYN [plasma membrane] (Homo sapiens)
Plexin-A1-4:FYN [plasma membrane] (Homo sapiens)
Plexin-A1-4 [plasma membrane] (Homo sapiens)
PLXNA2 [plasma membrane] (Homo sapiens)
Sema3A:Nrp-1:PlexinA:Fyn:pCdk5 [plasma membrane] (Homo sapiens)
NRP1:PlexinA1-4:FYN:pCdk5:p53 [plasma membrane] (Homo sapiens)
PlexinA1-4:FYN:pCdk5:p35 [plasma membrane] (Homo sapiens)
Plexin-A1-4 [plasma membrane] (Homo sapiens)
PLXNA2 [plasma membrane] (Homo sapiens)
Other semaphorin interactions (Homo sapiens)
SEMA6A binds to PLXNA2 and PLXNA4 (Homo sapiens)
PLXNA2,PLXNA4 [plasma membrane] (Homo sapiens)
PLXNA2 [plasma membrane] (Homo sapiens)
SEMA6A:PLXNA2,PLXNA4 [plasma membrane] (Homo sapiens)
PLXNA2,PLXNA4 [plasma membrane] (Homo sapiens)
PLXNA2 [plasma membrane] (Homo sapiens)
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion (Homo sapiens)
Inactivation of R-Ras by Sema3A-Plexin-A GAP activity (Homo sapiens)
Plexin-A1-4 [plasma membrane] (Homo sapiens)
PLXNA2 [plasma membrane] (Homo sapiens)
Phosphorylation of Plexin-A (Homo sapiens)
Sema3A:Nrp-1:Plexin A:Fyn [plasma membrane] (Homo sapiens)
NRP1:Plexin-A1-4:FYN [plasma membrane] (Homo sapiens)
Plexin-A1-4 [plasma membrane] (Homo sapiens)
PLXNA2 [plasma membrane] (Homo sapiens)
Plexin-A1-4 binds NRP1 (Homo sapiens)
NRP1:PlexinA1-4:FARP2:FYN [plasma membrane] (Homo sapiens)
Plexin-A1-4:FYN:FARP2 [plasma membrane] (Homo sapiens)
Plexin-A1-4:FYN [plasma membrane] (Homo sapiens)
Plexin-A1-4 [plasma membrane] (Homo sapiens)
PLXNA2 [plasma membrane] (Homo sapiens)
Plexin-A1-4:FYN [plasma membrane] (Homo sapiens)
Plexin-A1-4 [plasma membrane] (Homo sapiens)
PLXNA2 [plasma membrane] (Homo sapiens)
Sema3A binds Nrp-1 bound to PlexinA (Homo sapiens)
NRP1:PlexinA1-4:FARP2:FYN [plasma membrane] (Homo sapiens)
Plexin-A1-4:FYN:FARP2 [plasma membrane] (Homo sapiens)
Plexin-A1-4:FYN [plasma membrane] (Homo sapiens)
Plexin-A1-4 [plasma membrane] (Homo sapiens)
PLXNA2 [plasma membrane] (Homo sapiens)
Sema3A:Nrp-1:Plexin A:Fyn [plasma membrane] (Homo sapiens)
NRP1:Plexin-A1-4:FYN [plasma membrane] (Homo sapiens)
Plexin-A1-4 [plasma membrane] (Homo sapiens)
PLXNA2 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:O75051 PLXNA2
Gene Names
PLXNA2, KIAA0463, OCT, PLXN2, UNQ209/PRO235
Chain
signal peptide:1-34, chain:35-1894
Reference Genes
BioGPS Gene:5362 PLXNA2
COSMIC (genes):PLXNA2 PLXNA2
CTD Gene:5362 PLXNA2
dbSNP Gene:5362 PLXNA2
ENSEMBL:ENSG00000076356 PLXNA2
HGNC:9100 PLXNA2
KEGG:hsa:5362 PLXNA2
Monarch:5362 PLXNA2
NCBI Gene:5362 PLXNA2
OMIM:601054 PLXNA2
UCSC:O75051 PLXNA2
Reference Transcript
RefSeq:NM_025179.3 PLXNA2
Other Identifiers
11720562_a_at
11720563_at
16698816
207290_PM_at
207290_at
213030_PM_s_at
213030_s_at
227032_PM_at
227032_at
2453366
2453367
2453369
2453371
2453372
2453373
2453374
2453375
2453376
2453377
2453378
2453382
2453384
2453387
2453388
2453389
2453390
2453391
2453392
2453393
2453396
2453398
2453399
2453401
2453402
2453403
2453404
2453406
2453413
2453414
2453415
2453419
2453421
2453422
2453424
2453425
2453440
2453451
2453452
2453453
2453454
2453455
2453456
2453457
2453459
2453460
2453463
2453464
40395_at
5362
54877_at
56539_at
7923991
A_23_P307544
A_23_P46618
GE476341
GE53202
GO:0001756
GO:0002116
GO:0005515
GO:0005886
GO:0007162
GO:0007166
GO:0008360
GO:0017154
GO:0021915
GO:0021935
GO:0030334
GO:0042802
GO:0048856
GO:0048870
GO:0050772
GO:0051642
GO:0060037
GO:0060089
GO:0060174
GO:0071526
HMNXSV003002733
HMNXSV003022410
Hs.290927.0.A1_3p_at
Hs.300622.1.S1_3p_a_at
ILMN_1680617
ILMN_1844408
PH_hs_0015467
PH_hs_0032777
TC01003778.hg
TC01006075.hg
g13378152_3p_at
Participates
as a member of
PLXNA2,PLXNA4 [plasma membrane] (Homo sapiens)
Plexin-A1-4 [plasma membrane] (Homo sapiens)
as a component of
Plexin-A2:Neuropilin-1:Fyn [plasma membrane] (Homo sapiens)
Other forms of this molecule
p-Y-PLXNA2 [plasma membrane]
Inferred To
Plxna2 [plasma membrane]
(Rattus norvegicus)
plxna2 [plasma membrane]
(Danio rerio)
plxna2 [plasma membrane]
(Xenopus tropicalis)
PlexA [plasma membrane]
(Drosophila melanogaster)
plx-1 [plasma membrane]
(Caenorhabditis elegans)
PLXNA2 [plasma membrane]
(Bos taurus)
PLXNA2 [plasma membrane]
(Gallus gallus)
PLXNA2 [plasma membrane]
(Sus scrofa)
Plexin-A2 [plasma membrane]
(Mus musculus)
Cross References
ENSEMBL
ENSG00000076356
,
ENST00000367033
,
ENSP00000356000
OpenTargets
ENSG00000076356
GeneCards
PLXNA2
HPA
ENSG00000076356-PLXNA2
PRO
O75051
Pharos - Targets
O75051
GlyGen
O75051
PDB
3Q3J
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P59665 DEFA1
9
DEFA1(1-94) [Golgi lumen]
(R-HSA-1467215)
DEFA1(20-94) [Golgi lumen]
(R-HSA-1467282)
DEFA1(66-94) [Golgi lumen]
(R-HSA-975663)
DEFA1(20-65) [Golgi lumen]
(R-HSA-8864970)
DEFA1(66-94) [extracellular region]
(R-HSA-1461998)
DEFA1(66-94) [azurophil granule lumen]
(R-HSA-1470038)
DEFA1(65-94) [extracellular region]
(R-HSA-1462022)
omega-N-(ADP-ribosyl)-L-arginine-DEFA1(65-94) [extracellular region]
(R-HSA-1972397)
DEFA1(65-94) [azurophil granule lumen]
(R-HSA-1470053)
0.527
2
UniProt:P43630 KIR3DL2
1
KIR3DL2 [plasma membrane]
(R-HSA-197713)
0.527
2
UniProt:P01375 TNF
5
TNF(1-233) [plasma membrane]
(R-HSA-66220)
TNF(77-233) [extracellular region]
(R-HSA-976821)
TNF(1-76) [plasma membrane]
(R-HSA-8863120)
TNF(1-34) [plasma membrane]
(R-HSA-8863367)
TNF(52-76) [extracellular region]
(R-HSA-8863375)
0.527
2
UniProt:Q01523 DEFA5
5
DEFA5(1-94) [Golgi lumen]
(R-HSA-1467267)
DEFA5(20-94) [Golgi lumen]
(R-HSA-1467208)
DEFA5(20-94) [secretory granule lumen]
(R-HSA-1471358)
DEFA5(20-94) [extracellular region]
(R-HSA-1471344)
DEFA5(?-94) [extracellular region]
(R-HSA-1462017)
0.527
2
UniProt:P39688 Fyn
6
Fyn [cytosol]
(R-MMU-420333)
MyrG,p-Y420-Fyn [plasma membrane]
(R-MMU-9037733)
phospho-p-Y420-FYN [cytosol]
(R-MMU-391821)
pFyn(Y531) [cytosol]
(R-MMU-420350)
pFyn (420) [cytosol]
(R-MMU-420335)
phospho-p-S21,Y420-FYN [cytosol]
(R-MMU-5218745)
0.499
3
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