Reactome | phospho-Fyn [cytosol]

phospho-Fyn [cytosol]

Stable Identifier

R-MMU-5218745

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

p-S21,Y420-FYN, P39688

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P39688 Fyn

Gene Names

Fyn

Chain

initiator methionine:1, chain:2-537

Reference Genes

BioGPS Gene:14360 Fyn

ENSEMBL:ENSMUSG00000019843 Fyn

KEGG Gene (Mus musculus):14360 Fyn

Monarch:14360 Fyn

NCBI Gene:14360 Fyn

UCSC:P39688 Fyn

Reference Transcript

Other Identifiers

100133_at

10362596

1417558_at

14360

1448765_at

17232649

4314829

4397041

4466414

4541435

4580322

4654065

4676338

4715314

4725505

4743495

4781355

4858624

4940270

4945244

4963615

5066773

5108731

5151999

5281641

5312172

5529442

5554180

5559307

A_66_P138915

GO:0003674

GO:0004672

GO:0004713

GO:0005515

GO:0005524

GO:0006464

GO:0006468

GO:0008150

GO:0016301

GO:0043167

ILMN_2663821

ILMN_2730490

ILMN_2751207

mMC016479

u70324_s_at

Participates

as a component of

VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Mus musculus)

Other forms of this molecule

phospho-Fyn [plasma membrane]

Fyn [cytosol]

pFyn (420) [cytosol]

pFyn(Y531) [cytosol]

MyrG,p-Y420-Fyn [plasma membrane]

Inferred From

p-S21,Y420-FYN [cytosol] (Homo sapiens)

Modified Residues

Name

O4'-phospho-L-tyrosine at 420

Coordinate

420

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O-phospho-L-serine at 21 (in Homo sapiens)

Coordinate

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Cross References

RefSeq

NP_032080.2, NP_001116365.1, NP_001116364.1, XP_006512603.1, XP_011241419.1, XP_006512602.1

ZINC - Substances

FYN_MOUSE

ZINC target

P39688

Ensembl

ENSMUSP00000114188, ENSMUST00000135242, ENSMUST00000063091, ENSMUSP00000117111, ENSMUST00000146287, ENSMUSP00000057707, ENSMUST00000126486, ENSMUSP00000115233, ENSMUST00000099967, ENSMUSG00000019843, ENSMUSP00000097547

PRO

P39688

MGI

95602

ZINC - Predictions - Purchasable

FYN_MOUSE

PDB

3UF4

Interactors (13)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9QUM4 SLAF1			0.82	15
UniProt:P22681 CBL	39	CBL R420Q [cytosol] (R-HSA-9706186) CBL R420G [cytosol] (R-HSA-9706203) CBL Y371H [cytosol] (R-HSA-9706680) CBL H398Y [cytosol] (R-HSA-9706639) CBL P417A [cytosol] (R-HSA-9706636) CBL S376F [cytosol] (R-HSA-9706643) CBL del366-409 [cytosol] (R-HSA-9706179) CBL del366-477 [cytosol] (R-HSA-9706176) CBL R499L [cytosol] (R-HSA-9706678) CBL L380P [cytosol] (R-HSA-9706630) CBL L287R [cytosol] (R-HSA-9706693) CBL L380R [cytosol] (R-HSA-9706635) CBL G375P [cytosol] (R-HSA-9706219) CBL P417L [cytosol] (R-HSA-9706634) CBL H398Q [cytosol] (R-HSA-9706633) CBL P417R [cytosol] (R-HSA-9706632) CBL R499* [cytosol] (R-HSA-9706670) CBL H398R [cytosol] (R-HSA-9706638) CBL H398P [cytosol] (R-HSA-9706637) CBL G375fs16 [cytosol] (R-HSA-9706211) CBL R420 [cytosol] (R-HSA-9706208) CBL H398D [cytosol] (R-HSA-9706631) CBL Y371C [cytosol] (R-HSA-9706694) CBL G375S [cytosol] (R-HSA-9706214) CBL Y371D [cytosol] (R-HSA-9706687) CBL Y371S [cytosol] (R-HSA-9706674) CBL P417S [cytosol] (R-HSA-9706642) CBL H398N [cytosol] (R-HSA-9706641) CBL R420P [cytosol] (R-HSA-9706193) CBL Y371N [cytosol] (R-HSA-9706679) CBL R499Q [cytosol] (R-HSA-9706677) CBL R420L [cytosol] (R-HSA-9706197) CBL P417H [cytosol] (R-HSA-9706644) p-Y371-CBL [cytosol] (R-HSA-182940) p-Y371-CBL [plasma membrane] (R-HSA-182923) PolyUb,p-Y700,Y731,Y774-CBL [cytosol] (R-HSA-8848826) p-Y700,Y731,Y774-CBL [cytosol] (R-HSA-912656) p-Y-CBL [cytosol] (R-HSA-8875457) CBL [cytosol] (R-HSA-112199)	0.591	3
UniProt:Q60749	3	phospho-Khdrbs1 [cytosol] (R-MMU-8848995) Khdrbs1 [nucleoplasm] (R-MMU-8848941) phospho-Khdrbs1 [nucleoplasm] (R-MMU-8848970)	0.573	15
UniProt:P22682	6	phospho-Cbl [plasma membrane] (R-MMU-182923) phospho-Cbl [cytosol] (R-MMU-182940) phospho-Cbl [cytosol] (R-MMU-8848826) phospho-Cbl [cytosol] (R-MMU-912656) phospho-Cbl [cytosol] (R-MMU-8875457) Cbl [cytosol] (R-MMU-112199)	0.564	5
UniProt:P18052	1	Ptpra [plasma membrane] (R-MMU-388755)	0.564	2
UniProt:O88890	1	Sh2d1a [cytosol] (R-MMU-5685108)	0.564	4
UniProt:Q9JIA7	1	Sphk2 [cytosol] (R-MMU-428236)	0.544	2
UniProt:Q14332 FZD2	2	FZD2 [plasma membrane] (R-HSA-443945) FZD2 [clathrin-coated endocytic vesicle membrane] (R-HSA-5140723)	0.525	4
UniProt:P18433 PTPRA	1	PTPRA [plasma membrane] (R-HSA-388755)	0.524	2
UniProt:O75051 PLXNA2	2	p-Y-PLXNA2 [plasma membrane] (R-HSA-419607) PLXNA2 [plasma membrane] (R-HSA-396934)	0.499	3
UniProt:Q3U1F9	2	phospho-Pag1 [plasma membrane] (R-MMU-180494) Pag1 [plasma membrane] (R-MMU-180500)	0.499	4
UniProt:Q9JJG6 TMM47			0.463	2
UniProt:P35570 Irs1	7	p-Y-Irs1 [cytosol] (R-RNO-112362) Irs1 [cytosol] (R-RNO-1168867) phospho-Irs1 [plasma membrane] (R-RNO-2445090) Irs1 [plasma membrane] (R-RNO-2425392) Irs1 [cytosol] (R-RNO-74769) phospho-Irs1 [cytosol] (R-RNO-74772) phospho-Irs1 [plasma membrane] (R-RNO-198366)	0.462	4

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