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phospho-Fyn [cytosol]
Stable Identifier
R-MMU-5218745
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
cytosol
Synonyms
p-S21,Y420-FYN, P39688
Locations in the PathwayBrowser
Expand all
Signal Transduction (Mus musculus)
Signaling by Receptor Tyrosine Kinases (Mus musculus)
Signaling by VEGF (Mus musculus)
VEGFA-VEGFR2 Pathway (Mus musculus)
CDC42:GTP binds PAK2 (Mus musculus)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN:PAK2 [plasma membrane] (Mus musculus)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Mus musculus)
phospho-Fyn [cytosol] (Mus musculus)
VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:PAK2:CDC42:GTP [plasma membrane] (Mus musculus)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Mus musculus)
phospho-Fyn [cytosol] (Mus musculus)
FYN phosphorylates PAK2 (Mus musculus)
VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:p-2Y-PAK2:CDC42:GTP [plasma membrane] (Mus musculus)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Mus musculus)
phospho-Fyn [cytosol] (Mus musculus)
VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:p-3Y-PAK2:CDC42:GTP [plasma membrane] (Mus musculus)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Mus musculus)
phospho-Fyn [cytosol] (Mus musculus)
phospho-Fyn [cytosol] (Mus musculus)
PAK2 autophorylates (Mus musculus)
VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:PAK2:CDC42:GTP [plasma membrane] (Mus musculus)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Mus musculus)
phospho-Fyn [cytosol] (Mus musculus)
VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:p-2Y-PAK2:CDC42:GTP [plasma membrane] (Mus musculus)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Mus musculus)
phospho-Fyn [cytosol] (Mus musculus)
PAK2 binds NCK (Mus musculus)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Mus musculus)
phospho-Fyn [cytosol] (Mus musculus)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN:PAK2 [plasma membrane] (Mus musculus)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Mus musculus)
phospho-Fyn [cytosol] (Mus musculus)
p-Y420-FYN is phosphorylated on S21 (Mus musculus)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Mus musculus)
phospho-Fyn [cytosol] (Mus musculus)
p38 MAPK activation by VEGFR (Mus musculus)
VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:p-3Y-PAK2:CDC42:GTP [plasma membrane] (Mus musculus)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Mus musculus)
phospho-Fyn [cytosol] (Mus musculus)
External Reference Information
External Reference
UniProt:P39688 Fyn
Gene Names
Fyn
Chain
initiator methionine:1, chain:2-537
Reference Genes
BioGPS Gene:14360 Fyn
ENSEMBL:ENSMUSG00000019843 Fyn
KEGG Gene (Mus musculus):14360 Fyn
Monarch:14360 Fyn
NCBI Gene:14360 Fyn
UCSC:P39688 Fyn
Reference Transcript
RefSeq:NM_001122893.1 Fyn
RefSeq:NM_001122892.1 Fyn
RefSeq:NM_008054.2 Fyn
RefSeq:XM_006512540.3 Fyn
RefSeq:XM_011243117.2 Fyn
RefSeq:XM_006512539.3 Fyn
Other Identifiers
100133_at
10362596
1417558_at
14360
1448765_at
17232649
4314829
4397041
4466414
4541435
4580322
4654065
4676338
4715314
4725505
4743495
4781355
4858624
4940270
4945244
4963615
5066773
5108731
5151999
5281641
5312172
5529442
5554180
5559307
A_66_P138915
GO:0003674
GO:0004672
GO:0004713
GO:0005515
GO:0005524
GO:0006464
GO:0006468
GO:0008150
GO:0016301
GO:0043167
ILMN_2663821
ILMN_2730490
ILMN_2751207
mMC016479
u70324_s_at
Participates
as a component of
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Mus musculus)
Other forms of this molecule
phospho-Fyn [plasma membrane]
Fyn [cytosol]
pFyn (420) [cytosol]
pFyn(Y531) [cytosol]
MyrG,p-Y420-Fyn [plasma membrane]
Inferred From
p-S21,Y420-FYN [cytosol]
(Homo sapiens)
Modified Residues
Name
O4'-phospho-L-tyrosine at 420
Coordinate
420
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O-phospho-L-serine at 21 (in Homo sapiens)
Coordinate
21
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
NP_032080.2
,
NP_001116365.1
,
NP_001116364.1
,
XP_006512603.1
,
XP_011241419.1
,
XP_006512602.1
ZINC - Substances
FYN_MOUSE
ZINC target
P39688
Ensembl
ENSMUSP00000114188
,
ENSMUST00000135242
,
ENSMUST00000063091
,
ENSMUSP00000117111
,
ENSMUST00000146287
,
ENSMUSP00000057707
,
ENSMUST00000126486
,
ENSMUSP00000115233
,
ENSMUST00000099967
,
ENSMUSG00000019843
,
ENSMUSP00000097547
PRO
P39688
MGI
95602
ZINC - Predictions - Purchasable
FYN_MOUSE
PDB
3UF4
Interactors (13)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9QUM4 SLAF1
0.82
15
UniProt:P22681 CBL
39
CBL R420Q [cytosol]
(R-HSA-9706186)
CBL R420G [cytosol]
(R-HSA-9706203)
CBL Y371H [cytosol]
(R-HSA-9706680)
CBL H398Y [cytosol]
(R-HSA-9706639)
CBL P417A [cytosol]
(R-HSA-9706636)
CBL S376F [cytosol]
(R-HSA-9706643)
CBL del366-409 [cytosol]
(R-HSA-9706179)
CBL del366-477 [cytosol]
(R-HSA-9706176)
CBL R499L [cytosol]
(R-HSA-9706678)
CBL L380P [cytosol]
(R-HSA-9706630)
CBL L287R [cytosol]
(R-HSA-9706693)
CBL L380R [cytosol]
(R-HSA-9706635)
CBL G375P [cytosol]
(R-HSA-9706219)
CBL P417L [cytosol]
(R-HSA-9706634)
CBL H398Q [cytosol]
(R-HSA-9706633)
CBL P417R [cytosol]
(R-HSA-9706632)
CBL R499* [cytosol]
(R-HSA-9706670)
CBL H398R [cytosol]
(R-HSA-9706638)
CBL H398P [cytosol]
(R-HSA-9706637)
CBL G375fs*16 [cytosol]
(R-HSA-9706211)
CBL R420* [cytosol]
(R-HSA-9706208)
CBL H398D [cytosol]
(R-HSA-9706631)
CBL Y371C [cytosol]
(R-HSA-9706694)
CBL G375S [cytosol]
(R-HSA-9706214)
CBL Y371D [cytosol]
(R-HSA-9706687)
CBL Y371S [cytosol]
(R-HSA-9706674)
CBL P417S [cytosol]
(R-HSA-9706642)
CBL H398N [cytosol]
(R-HSA-9706641)
CBL R420P [cytosol]
(R-HSA-9706193)
CBL Y371N [cytosol]
(R-HSA-9706679)
CBL R499Q [cytosol]
(R-HSA-9706677)
CBL R420L [cytosol]
(R-HSA-9706197)
CBL P417H [cytosol]
(R-HSA-9706644)
p-Y371-CBL [cytosol]
(R-HSA-182940)
p-Y371-CBL [plasma membrane]
(R-HSA-182923)
PolyUb,p-Y700,Y731,Y774-CBL [cytosol]
(R-HSA-8848826)
p-Y700,Y731,Y774-CBL [cytosol]
(R-HSA-912656)
p-Y-CBL [cytosol]
(R-HSA-8875457)
CBL [cytosol]
(R-HSA-112199)
0.591
3
UniProt:Q60749
3
phospho-Khdrbs1 [cytosol]
(R-MMU-8848995)
Khdrbs1 [nucleoplasm]
(R-MMU-8848941)
phospho-Khdrbs1 [nucleoplasm]
(R-MMU-8848970)
0.573
15
UniProt:P22682
6
phospho-Cbl [plasma membrane]
(R-MMU-182923)
phospho-Cbl [cytosol]
(R-MMU-182940)
phospho-Cbl [cytosol]
(R-MMU-8848826)
phospho-Cbl [cytosol]
(R-MMU-912656)
phospho-Cbl [cytosol]
(R-MMU-8875457)
Cbl [cytosol]
(R-MMU-112199)
0.564
5
UniProt:P18052
1
Ptpra [plasma membrane]
(R-MMU-388755)
0.564
2
UniProt:O88890
1
Sh2d1a [cytosol]
(R-MMU-5685108)
0.564
4
UniProt:Q9JIA7
1
Sphk2 [cytosol]
(R-MMU-428236)
0.544
2
UniProt:Q14332 FZD2
2
FZD2 [plasma membrane]
(R-HSA-443945)
FZD2 [clathrin-coated endocytic vesicle membrane]
(R-HSA-5140723)
0.525
4
UniProt:P18433 PTPRA
1
PTPRA [plasma membrane]
(R-HSA-388755)
0.524
2
UniProt:O75051 PLXNA2
2
p-Y-PLXNA2 [plasma membrane]
(R-HSA-419607)
PLXNA2 [plasma membrane]
(R-HSA-396934)
0.499
3
UniProt:Q3U1F9
2
phospho-Pag1 [plasma membrane]
(R-MMU-180494)
Pag1 [plasma membrane]
(R-MMU-180500)
0.499
4
UniProt:Q9JJG6 TMM47
0.463
2
UniProt:P35570 Irs1
7
p-Y-Irs1 [cytosol]
(R-RNO-112362)
Irs1 [cytosol]
(R-RNO-1168867)
phospho-Irs1 [plasma membrane]
(R-RNO-2445090)
Irs1 [plasma membrane]
(R-RNO-2425392)
Irs1 [cytosol]
(R-RNO-74769)
phospho-Irs1 [cytosol]
(R-RNO-74772)
phospho-Irs1 [plasma membrane]
(R-RNO-198366)
0.462
4
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