Reactome | Multiple phosphorylated FAK [cytosol]

Multiple phosphorylated FAK [cytosol]

Stable Identifier

R-MMU-420344

Type

Genes and Transcripts [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

External Reference Information

External Reference

UniProt:P34152-4 Ptk2

Gene Names

Ptk2, Fadk, Fak, Fak1, Kiaa4203

Other Identifiers

10429341

14083

1423059_at

1430827_a_at

167825_r_at

17317858

4386227

4401103

4407572

4432301

4441659

4443338

4524128

4545642

4557284

4619807

4622929

4647920

4675762

4679236

4703443

4704101

4781786

4797825

4803094

4803357

4815069

4816125

4819792

4864803

4890851

4907985

4931592

4946451

4970816

5059992

5080094

5100085

5117839

5122131

5123711

5143171

5153747

5177069

5191803

5205664

5208425

5224059

5255998

5267333

5318829

5343889

5364113

5382571

5387586

5398524

5459628

5464361

5484230

5534854

5556700

5575936

5597162

5614128

97363_at

A_51_P216219

A_52_P359381

A_52_P58585

A_55_P2349258

A_55_P2349265

A_55_P2742078

GE34373

GO:0000166

GO:0000226

GO:0001525

GO:0001568

GO:0001570

GO:0001764

GO:0001934

GO:0003824

GO:0004672

GO:0004713

GO:0004715

GO:0005515

GO:0005524

GO:0005634

GO:0005737

GO:0005813

GO:0005815

GO:0005829

GO:0005856

GO:0005886

GO:0005925

GO:0005938

GO:0006468

GO:0007010

GO:0007097

GO:0007172

GO:0007173

GO:0007229

GO:0007409

GO:0008284

GO:0008360

GO:0010507

GO:0010613

GO:0016020

GO:0016301

GO:0016324

GO:0016477

GO:0016740

GO:0018108

GO:0021955

GO:0030027

GO:0030054

GO:0030154

GO:0030155

GO:0030198

GO:0030335

GO:0033628

GO:0035265

GO:0036064

GO:0040008

GO:0042127

GO:0042995

GO:0043066

GO:0043542

GO:0045667

GO:0045860

GO:0046621

GO:0046777

GO:0048013

GO:0048471

GO:0048856

GO:0048870

GO:0050767

GO:0050771

GO:0051239

GO:0051897

GO:0051964

GO:0065003

GO:0065008

GO:0070161

GO:0071560

GO:0098978

GO:0140096

GO:1905274

GO:2000060

ILMN_1240840

ILMN_2615901

M95408_s_at

mMC010925

Participates

as a component of

Multiple phosphorylated FAK bound to NCAM:pFyn (420) [plasma membrane] (Mus musculus)

Other forms of this molecule

phospho-p-6Y-PTK2 [cytosol]

phospho-p-Y397-PTK2 [cytosol]

PTK2 [cytosol]

Focal adhesion kinase 1 [cytosol]

pFAK (397) [cytosol]

PTK2(1-772) [cytosol]

PTK2(773-1052) [cytosol]

phospho-p-6Y,S732-PTK2 [cytosol]

phospho-p-5Y,S732-PTK2 [cytosol]

phospho-p-5Y-PTK2 [cytosol]

phospho-pY-PTK2 [cytosol]

phospho-p-Y194,Y397-PTK2 [cytosol]

phospho-p-Y194,Y397,Y576,Y577-PTK2 [cytosol]

Modified Residues

Name

O4'-phospho-L-tyrosine at 397

Coordinate

397

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 407

Coordinate

407

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 576

Coordinate

576

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 577

Coordinate

577

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 861

Coordinate

861

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 925

Coordinate

925

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

NP_032008.2, XP_030104191.1, XP_036015042.1, XP_030104192.1

ENSEMBL

ENSMUSP00000155470, ENSMUSP00000154242, ENSMUST00000228180, ENSMUST00000226988, ENSMUSG00000022607, ENSMUSP00000105663, ENSMUST00000110036

IntEnz

2.7.10.2

PRO

P34152

MGI

95481

PDB

6BZ3, 5F28, 1K40

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q8VI36	4	Pxn [plasma membrane] (R-MMU-180493) phospho-Pxn [plasma membrane] (R-MMU-9031680) Pxn [cytosol] (R-MMU-210014) phospho-Pxn [cytosol] (R-MMU-5218693)	0.784	6
UniProt:Q61140 Bcar1	6	Bcar1 [cytosol] (R-MMU-201625) phospho-Bcar1 [cytosol] (R-MMU-8848723) phospho-Bcar1 [cytosol] (R-MMU-5218739) p130Cas [cytosol] (R-MMU-5218743) p-12Y-P130Cas [cytosol] (R-MMU-5218727) phospho-Bcar1 [cytosol] (R-MMU-372645)	0.646	3
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.597	3
UniProt:P05480 Src	13	SRC-2 [cytosol] (R-MMU-191648) phospho-MyrG-p-Y419-SRC [plasma membrane] (R-MMU-1810408) SRC-1 [plasma membrane] (R-MMU-65043) phospho-MyrG,p-Y530-SRC [plasma membrane] (R-MMU-377598) phospho-p-Y419-SRC [cytosol] (R-MMU-377592) Src [cytosol] (R-MMU-418782) phospho-p-Y419-SRC-1 [plasma membrane] (R-MMU-112331) MyrG-SRC [plasma membrane] (R-MMU-8876922) phospho-p-Y419-SRC [cytosol] (R-MMU-8964276) SRC [cytosol] (R-MMU-9628701) MyrG-p-Y424-Src [plasma membrane] (R-MMU-9011258) Activated Src [nucleoplasm] (R-MMU-8937700) p-Y416-Src [cytosol] (R-MMU-8964306)	0.589	2
UniProt:P12931 SRC	6	MyrG-p-Y419-SRC [plasma membrane] (R-HSA-1810408) MyrG,p-Y530-SRC [plasma membrane] (R-HSA-377598) MyrG-SRC [plasma membrane] (R-HSA-8876922) p-Y419-SRC [cytosol] (R-HSA-8964276) SRC [cytosol] (R-HSA-9628701) p-Y419-SRC [nucleoplasm] (R-HSA-8937690)	0.564	2
UniProt:Q60631 Grb2	3	Grb2 [cytosol] (R-MMU-74686) Grb2 [plasma membrane] (R-MMU-202993) Grb2 [cytosol] (R-MMU-443287)	0.508	2
UniProt:Q99JY9	1	Actr3 [cytosol] (R-MMU-200811)	0.463	2
UniProt:P49023 PXN	4	p-Y31,Y118-PXN [cytosol] (R-HSA-5218693) PXN [cytosol] (R-HSA-210014) p-Y-PXN [plasma membrane] (R-HSA-9031680) PXN [plasma membrane] (R-HSA-180493)	0.463	2
UniProt:P54763 Ephb2	9	phospho-p-Y596,Y602-EPHB2 [plasma membrane] (R-MMU-3928375) p-Ephb2 [plasma membrane] (R-MMU-3928433) EPHB2 [plasma membrane] (R-MMU-443809) EPHB2 (19-?) [extracellular region] (R-MMU-3928436) EPHB2 (?-1055) [plasma membrane] (R-MMU-3928386) EPHB2 (?-1055) [cytosol] (R-MMU-3928432) P54763 [plasma membrane] (R-MMU-3928394) Ephb2 [plasma membrane] (R-MMU-3928443) p-Y604,Y610-Ephb2 [plasma membrane] (R-MMU-4093312)	0.463	3