Reactome | phospho-Pxn [cytosol]

phospho-Pxn [cytosol]

Stable Identifier

R-MMU-5218693

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

p-Y31,Y118-PXN, Q8VI36

Locations in the PathwayBrowser

Expand all

Signal Transduction (Mus musculus)

- Signaling by Non-Receptor Tyrosine Kinases (Mus musculus)
  - Signaling by PTK6 (Mus musculus)
    - PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases (Mus musculus)
      - Activation of RAC1 by the PXN:CRK complex (Mus musculus)
        
        p-Y31,Y118-PXN:CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Mus musculus)
        
        phospho-Pxn [cytosol] (Mus musculus)
      - PTK6 phosphorylates PXN (Mus musculus)
        
        phospho-Pxn [cytosol] (Mus musculus)
      - Phosphorylated PXN recruits the CRK complex (Mus musculus)
        
        p-Y31,Y118-PXN:CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Mus musculus)
        
        phospho-Pxn [cytosol] (Mus musculus)
        
        phospho-Pxn [cytosol] (Mus musculus)
- Signaling by Receptor Tyrosine Kinases (Mus musculus)
  - Signaling by VEGF (Mus musculus)
    - VEGFA-VEGFR2 Pathway (Mus musculus)
      - CRK binds BCAR1 and or PXN (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Mus musculus)
        
        phospho-Pxn [cytosol] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1/p-Y31,Y118-PAX:CRK [plasma membrane] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Mus musculus)
        
        phospho-Pxn [cytosol] (Mus musculus)
      - DOCK180:ELMO binds CRK (Mus musculus)
        
        CRK:DOCK180:ELMO1,ELMO2:VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Mus musculus)
        
        phospho-Pxn [cytosol] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1/p-Y31,Y118-PAX:CRK [plasma membrane] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Mus musculus)
        
        phospho-Pxn [cytosol] (Mus musculus)
      - DOCK180:ELMO exchanges GTP for GDP, activating RAC1 (Mus musculus)
        
        CRK:DOCK180:ELMO1,ELMO2:VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Mus musculus)
        
        phospho-Pxn [cytosol] (Mus musculus)
      - PTK2 and SRC-1 phosphorylate PXN on Y31 and Y118 (Mus musculus)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Mus musculus)
        
        phospho-Pxn [cytosol] (Mus musculus)

External Reference Information

External Reference

UniProt:Q8VI36

Gene Names

Pxn

Reference Genes

BioGPS Gene:19303 Pxn

ENSEMBL:ENSMUSG00000029528

KEGG:mmu:19303 Pxn

Monarch:19303 Pxn

NCBI Gene:19303 Pxn

UCSC:Q8VI36 Pxn

Reference Transcript

Other Identifiers

103398_at

10524703

1424027_at

1426085_a_at

1456135_s_at

17441168

19303

4369725

4389859

4414763

4416900

4468088

4488491

4558006

4681918

4696196

4707523

4784276

4795556

4814186

4880634

4891888

4918436

4953286

4957142

5053013

5072706

5121873

5185565

5197464

5204160

5219942

5275687

5332285

5373630

5383193

5387860

5435199

5439568

5447022

5455307

5466402

5479212

5486072

5498596

5542018

5552829

5557398

5596839

5599855

5605911

5614653

A_51_P214859

A_52_P317416

A_52_P532973

A_66_P134044

GE119263

GE127603

GO:0000165

GO:0005078

GO:0005178

GO:0005515

GO:0005737

GO:0005829

GO:0005856

GO:0005925

GO:0005938

GO:0007010

GO:0007155

GO:0007179

GO:0007229

GO:0008360

GO:0016477

GO:0019901

GO:0030027

GO:0030032

GO:0030159

GO:0031252

GO:0034330

GO:0034446

GO:0038191

GO:0043226

GO:0043542

GO:0044877

GO:0045766

GO:0046872

GO:0048041

GO:0048754

GO:0048870

GO:0051435

GO:0060090

GO:0070161

GO:1901652

ILMN_1225102

ILMN_2460293

ILMN_3047586

ILMN_3123303

mMC011168

Participates

as a component of

as an input of

Phosphorylated PXN recruits the CRK complex (Mus musculus)

as an output of

PTK6 phosphorylates PXN (Mus musculus)

Other forms of this molecule

phospho-Pxn [plasma membrane]

Pxn [plasma membrane]

Pxn [cytosol]

Inferred From

p-Y31,Y118-PXN [cytosol] (Homo sapiens)

Modified Residues

Name

O4'-phospho-L-tyrosine at 31 (in Homo sapiens)

Coordinate

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 118 (in Homo sapiens)

Coordinate

118

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

NP_598676.2, NP_035353.1

ENSEMBL

ENSMUSP00000069624, ENSMUST00000067268, ENSMUSG00000029528

PRO

Q8VI36

GlyGen

Q8VI36

MGI

108295

PDB

6JMU, 5W93

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P34152 Ptk2	13	phospho-p-6Y-PTK2 [cytosol] (R-MMU-354128) phospho-p-Y397-PTK2 [cytosol] (R-MMU-354068) PTK2 [cytosol] (R-MMU-201621) PTK2(1-772) [cytosol] (R-MMU-202827) PTK2(773-1052) [cytosol] (R-MMU-202829) phospho-p-6Y,S732-PTK2 [cytosol] (R-MMU-5218694) phospho-p-5Y,S732-PTK2 [cytosol] (R-MMU-5229006) phospho-p-5Y-PTK2 [cytosol] (R-MMU-5218711) Fak1 [cytosol] (R-MMU-3928448) p-Y428-FAK1 [cytosol] (R-MMU-3928397) phospho-pY-PTK2 [cytosol] (R-MMU-9632393) phospho-p-Y194,Y397-PTK2 [cytosol] (R-MMU-8874600) phospho-p-Y194,Y397,Y576,Y577-PTK2 [cytosol] (R-MMU-8874613)	0.784	6
UniProt:Q64727	6	Vcl [cytosol] (R-MMU-9861471) Vcl [specific granule lumen] (R-MMU-6799711) Vcl [secretory granule lumen] (R-MMU-6801010) Vcl [extracellular region] (R-MMU-350736) Vcl [ficolin-1-rich granule lumen] (R-MMU-6800985) Vcl [cytosol] (R-MMU-350753)	0.537	3