Reactome | phospho-p-Y397-PTK2 [cytosol]

phospho-p-Y397-PTK2 [cytosol]

Stable Identifier

R-MMU-354068

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

P34152

Locations in the PathwayBrowser

Expand all

Developmental Biology (Mus musculus)

- Nervous system development (Mus musculus)
  - Axon guidance (Mus musculus)
    - EPH-Ephrin signaling (Mus musculus)
      - EPHB-mediated forward signaling (Mus musculus)
        
        Recruitment of p190RhoGEF to p-FAK (Mus musculus)
        
        EFNBs:p-EPHBs:p-Y397-PTK2 [plasma membrane] (Mus musculus)
        
        phospho-p-Y397-PTK2 [cytosol] (Mus musculus)
        
        EFNBs:p-EPHBs:p-Y397-PTK2:ARHGEF28 [plasma membrane] (Mus musculus)
        
        EFNBs:p-EPHBs:p-Y397-PTK2 [plasma membrane] (Mus musculus)
        
        phospho-p-Y397-PTK2 [cytosol] (Mus musculus)
        
        p190RhoGEF exchanges GTP for GDP on RHOA, activating it (Mus musculus)
        
        EFNBs:p-EPHBs:p-Y397-PTK2:ARHGEF28 [plasma membrane] (Mus musculus)
        
        EFNBs:p-EPHBs:p-Y397-PTK2 [plasma membrane] (Mus musculus)
        
        phospho-p-Y397-PTK2 [cytosol] (Mus musculus)
    - Netrin-1 signaling (Mus musculus)
      - DCC mediated attractive signaling (Mus musculus)
        
        Activation of Cdc42 (Mus musculus)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane] (Mus musculus)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1 [plasma membrane] (Mus musculus)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN [plasma membrane] (Mus musculus)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2 [plasma membrane] (Mus musculus)
        
        phospho-p-Y397-PTK2 [cytosol] (Mus musculus)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO:CDC42:GTP [plasma membrane] (Mus musculus)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane] (Mus musculus)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1 [plasma membrane] (Mus musculus)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN [plasma membrane] (Mus musculus)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2 [plasma membrane] (Mus musculus)
        
        phospho-p-Y397-PTK2 [cytosol] (Mus musculus)
        
        Activation of Rac1 (Mus musculus)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane] (Mus musculus)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1 [plasma membrane] (Mus musculus)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN [plasma membrane] (Mus musculus)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2 [plasma membrane] (Mus musculus)
        
        phospho-p-Y397-PTK2 [cytosol] (Mus musculus)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO:RAC1:GTP [plasma membrane] (Mus musculus)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane] (Mus musculus)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1 [plasma membrane] (Mus musculus)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN [plasma membrane] (Mus musculus)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2 [plasma membrane] (Mus musculus)
        
        phospho-p-Y397-PTK2 [cytosol] (Mus musculus)
        
        DCC interacting NCK-1 (Mus musculus)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN [plasma membrane] (Mus musculus)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2 [plasma membrane] (Mus musculus)
        
        phospho-p-Y397-PTK2 [cytosol] (Mus musculus)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1 [plasma membrane] (Mus musculus)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN [plasma membrane] (Mus musculus)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2 [plasma membrane] (Mus musculus)
        
        phospho-p-Y397-PTK2 [cytosol] (Mus musculus)
        
        Phosphorylation of DCC by Fyn (Mus musculus)
        
        NTN1:DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN [plasma membrane] (Mus musculus)
        
        NTN1:DCC oligomer:p-Y397-PTK2 [plasma membrane] (Mus musculus)
        
        phospho-p-Y397-PTK2 [cytosol] (Mus musculus)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN [plasma membrane] (Mus musculus)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2 [plasma membrane] (Mus musculus)
        
        phospho-p-Y397-PTK2 [cytosol] (Mus musculus)
        
        RhoGTPase GEF's recruited to DCC (Mus musculus)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1 [plasma membrane] (Mus musculus)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN [plasma membrane] (Mus musculus)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2 [plasma membrane] (Mus musculus)
        
        phospho-p-Y397-PTK2 [cytosol] (Mus musculus)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane] (Mus musculus)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1 [plasma membrane] (Mus musculus)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN [plasma membrane] (Mus musculus)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2 [plasma membrane] (Mus musculus)
        
        phospho-p-Y397-PTK2 [cytosol] (Mus musculus)

External Reference Information

External Reference

UniProt:P34152 Ptk2

Gene Names

Ptk2, Fadk, Fak, Fak1, Kiaa4203

Chain

initiator methionine:, chain:2-1052

Reference Genes

BioGPS Gene:14083 Ptk2

KEGG:mmu:14083 Ptk2

Monarch:14083 Ptk2

NCBI Gene:14083 Ptk2

UCSC:P34152 Ptk2

Reference Transcript

Participates

as a component of

as an output of

Phosphorylation of PTK2 (FAK) on tyrosine-397 in response to turbulent blood flow (Mus musculus)

This entity regulates

Positively

PTK2 (FAK) and Gq/11 enhance the degradation of NFKBIA (IkBalpha), phosphorylation of RELA (p65) on serine-536, and translocation of p-S536-RELA:NFKB1 (p65:p50) to the nucleus (Mus musculus)

Other forms of this molecule

phospho-p-6Y-PTK2 [cytosol]

PTK2 [cytosol]

PTK2(1-772) [cytosol]

PTK2(773-1052) [cytosol]

phospho-p-6Y,S732-PTK2 [cytosol]

phospho-p-5Y,S732-PTK2 [cytosol]

phospho-p-5Y-PTK2 [cytosol]

Fak1 [cytosol]

p-Y428-FAK1 [cytosol]

phospho-pY-PTK2 [cytosol]

phospho-p-Y194,Y397-PTK2 [cytosol]

phospho-p-Y194,Y397,Y576,Y577-PTK2 [cytosol]

Inferred From

p-Y397-PTK2 [cytosol] (Homo sapiens)

Modified Residues

Name

O4'-phospho-L-tyrosine at 397 (in Homo sapiens)

Coordinate

397

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

XP_006520496.1, NP_001123881.1, NP_032008.2

ENSEMBL

ENSMUSG00000022607, ENSMUSP00000155470, ENSMUSP00000154242, ENSMUSP00000105663, ENSMUST00000228180, ENSMUST00000226988, ENSMUST00000110036

IntEnz

2.7.10.2

PRO

P34152

MGI

95481

PDB

1K40, 6BZ3, 5F28

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q8VI36	4	phospho-Pxn [plasma membrane] (R-MMU-9031680) Pxn [plasma membrane] (R-MMU-180493) Pxn [cytosol] (R-MMU-210014) phospho-Pxn [cytosol] (R-MMU-5218693)	0.784	6
UniProt:Q61140 Bcar1	6	Bcar1 [cytosol] (R-MMU-201625) phospho-Bcar1 [cytosol] (R-MMU-8848723) phospho-Bcar1 [cytosol] (R-MMU-5218739) p130Cas [cytosol] (R-MMU-5218743) p-12Y-P130Cas [cytosol] (R-MMU-5218727) phospho-Bcar1 [cytosol] (R-MMU-372645)	0.646	3
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.597	3
UniProt:P05480 Src	13	SRC-2 [cytosol] (R-MMU-191648) phospho-MyrG-p-Y419-SRC [plasma membrane] (R-MMU-1810408) SRC-1 [plasma membrane] (R-MMU-65043) phospho-MyrG,p-Y530-SRC [plasma membrane] (R-MMU-377598) phospho-p-Y419-SRC [cytosol] (R-MMU-377592) Src [cytosol] (R-MMU-418782) phospho-p-Y419-SRC-1 [plasma membrane] (R-MMU-112331) MyrG-SRC [plasma membrane] (R-MMU-8876922) MyrG-p-Y424-Src [plasma membrane] (R-MMU-9011258) SRC [cytosol] (R-MMU-9628701) phospho-p-Y419-SRC [cytosol] (R-MMU-8964276) Activated Src [nucleoplasm] (R-MMU-8937700) p-Y416-Src [cytosol] (R-MMU-8964306)	0.589	2
UniProt:P12931 SRC	6	MyrG-p-Y419-SRC [plasma membrane] (R-HSA-1810408) MyrG,p-Y530-SRC [plasma membrane] (R-HSA-377598) MyrG-SRC [plasma membrane] (R-HSA-8876922) SRC [cytosol] (R-HSA-9628701) p-Y419-SRC [cytosol] (R-HSA-8964276) p-Y419-SRC [nucleoplasm] (R-HSA-8937690)	0.564	2
UniProt:Q60631 Grb2	1	Grb2 [cytosol] (R-MMU-443287)	0.508	2
UniProt:P54763 Ephb2	9	phospho-p-Y596,Y602-EPHB2 [plasma membrane] (R-MMU-3928375) p-Ephb2 [plasma membrane] (R-MMU-3928433) EPHB2 [plasma membrane] (R-MMU-443809) EPHB2 (19-?) [extracellular region] (R-MMU-3928436) EPHB2 (?-1055) [plasma membrane] (R-MMU-3928386) EPHB2 (?-1055) [cytosol] (R-MMU-3928432) P54763 [plasma membrane] (R-MMU-3928394) Ephb2 [plasma membrane] (R-MMU-3928443) p-Y604,Y610-Ephb2 [plasma membrane] (R-MMU-4093312)	0.463	3
UniProt:P49023 PXN	4	p-Y31,Y118-PXN [cytosol] (R-HSA-5218693) PXN [cytosol] (R-HSA-210014) PXN [plasma membrane] (R-HSA-180493) p-Y-PXN [plasma membrane] (R-HSA-9031680)	0.463	2
UniProt:Q99JY9	1	Actr3 [cytosol] (R-MMU-200811)	0.463	2