GATA3, CHD4, EP300, NFATC2, YY1, ETS1, POU2F1 (OCT1), POU2F2 (OCT2), BATF, SATB1, IRF4, SMARCA4, and STAT6 positively regulate expression of IL13

Stable Identifier
R-HSA-9976402
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, extracellular region
ReviewStatus
5/5
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GATA3, CHD4, EP300, NFATC2, YY1, ETS1, POU2F1 (OCT1), POU2F2 (OCT2), BATF, SATB1, IRF4, SMARCA4, and STAT6 positively regulate expression of IL13
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GATA3, CHD4, and EP300 bind upstream of the IL13 gene. EP300 acetylates histones in the gene cluster that contains IL13 and IL4 (inferred from mouse homologs in Hosokawa et al. 2013). NFATC2 (NFAT1) binds the promoter of the IL13 gene and interacts with GATA3 (Yao et al. 2012). GATA3, NFATC2, CHD4, and EP300 enhance transcription of IL13 (Yao et al. 2012, inferred from mouse homologs in Kishikawa et al. 2001, Yamashita et al. 2002, Sasaki et al. 2013). GATA3, YY1, ETS1, POU2F1 (OCT1), POU2F2 (OCT2), BATF, SATB1, IRF4, SMARCA4, and STAT6 bound to the locus control region (LCR) also enhance expression. Continued activation by GATA3 is required for expression of IL13 in memory Th2 cells (inferred from mouse homologs in Sasaki et al. 2013).
Literature References
PubMed ID Title Journal Year
20368097 GATA3 siRNA inhibits the binding of NFAT1 to interleukin-13 promoter in human T cells

Yao, X, Yang, Y, He, HY, Wang, M, Yin, KS, Huang, M

Chin Med J (Engl) 2010
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
GATA3:YY1:ETS1:POU2F1:POU2F2:BATF:p-Y641-STAT6:SATB1:IRF4:SMARCA4:RAD50 gene [nucleoplasm] (Homo sapiens)
Active Unit
ETS1 [nucleoplasm]
GATA3 [nucleoplasm]
POU2F1 [nucleoplasm]
POU2F2 [nucleoplasm]
p-Y641-STAT6 dimer [nucleoplasm]
Regulator
GATA3:CHD4:EP300:p-S243-NFATC2:IL13 gene [nucleoplasm] (Homo sapiens)
Active Unit
GATA3 [nucleoplasm]
Inferred From
Gata3, Chd4, Ep300, Nfatc2, Yy1, Ets1, Pou2f1 (Oct1), Pou2f2 (Oct2), Batf, Satb1, Irf4, Smarca4, and Stat6 positively regulate expression of Il13 (Mus musculus)
Authored
May, B  (2025-12-11)
Reviewed
Barbutti, I  (2026-02-24)
Lord, GM  (2026-02-26)
Created
May, B  (2025-12-11)
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