Gata3, Chd4, Ep300, Nfatc2, Yy1, Ets1, Pou2f1 (Oct1), Pou2f2 (Oct2), Batf, Satb1, Irf4, Smarca4, and Stat6 positively regulate expression of Il13

Stable Identifier
R-MMU-9978121
Type
Reaction [omitted]
Species
Mus musculus
Compartment
nucleoplasm, extracellular region
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Gata3, Chd4, Ep300, Nfatc2, Yy1, Ets1, Pou2f1 (Oct1), Pou2f2 (Oct2), Batf, Satb1, Irf4, Smarca4, and Stat6 positively regulate expression of Il13
Gata3, Chd4, and Ep300 bind upstream of the Il13 gene. Ep300 acetylates histones in the gene cluster that contains Il13 and Il4 (Hosokawa et al. 2013). Nfatc2 (Nfat1) binds the promoter of the Il13 gene and interacts with Gata3 (inferred from human homologs in Yao et al. 2012). Gata3, Nfatc2, Chd4, and Ep300 enhance transcription of Il13 (Kishikawa et al. 2001, Yamashita et al. 2002, Sasaki et al. 2013). Gata3, Yy1, Ets1, Pou2f1 (Oct1), Pou2f2 (Oct2), Batf, Satb1, Irf4, Smarca4, and Stat6 bound to the locus control region (LCR) also enhance expression. Continued activation by Gata3 is required for expression of Il13 in memory Th2 cells (Sasaki et al. 2013).
Literature References
PubMed ID Title Journal Year
12205084 Identification of a conserved GATA3 response element upstream proximal from the interleukin-13 gene locus

Yamashita, M, Ukai-Tadenuma, M, Kimura, M, Omori, M, Inami, M, Taniguchi, M, Nakayama, T

J Biol Chem 2002
23471993 Functionally distinct Gata3/Chd4 complexes coordinately establish T helper 2 (Th2) cell identity

Hosokawa, H, Tanaka, T, Suzuki, Y, Iwamura, C, Ohkubo, S, Endoh, K, Kato, M, Endo, Y, Onodera, A, Tumes, DJ, Kanai, A, Sugano, S, Nakayama, T

Proc Natl Acad Sci U S A 2013
23824597 Genome-Wide Gene Expression Profiling Revealed a Critical Role for GATA3 in the Maintenance of the Th2 Cell Identity

Sasaki, T, Onodera, A, Hosokawa, H, Watanabe, Y, Horiuchi, S, Yamashita, J, Tanaka, H, Ogawa, Y, Suzuki, Y, Nakayama, T

PLoS One 2013
11591766 The cell type-specific expression of the murine IL-13 gene is regulated by GATA-3

Kishikawa, H, Sun, J, Choi, A, Miaw, SC, Ho, IC

J Immunol 2001
Participants
Input
Output
This event is regulated
Positively by
Regulator
Gata3:Yy1:Ets1:Pou2f1:Pou2f2:Batf:Irf4:Satb1:Smarca4:p-Y641-Stat6:Rad50 gene [nucleoplasm] (Mus musculus)
Regulator
Gata3:Chd4:Ep300:p-S245-Nfatc2:Il13 gene [nucleoplasm] (Mus musculus)
Active Unit
Gata3 [nucleoplasm]
p-S245-Nfatc2 [nucleoplasm]
Orthologous Events
GATA3, CHD4, EP300, NFATC2, YY1, ETS1, POU2F1 (OCT1), POU2F2 (OCT2), BATF, SATB1, IRF4, SMARCA4, and STAT6 positively regulate expression of IL13 (Homo sapiens)
Authored
May, B  (2025-12-27)
Reviewed
Barbutti, I  (2026-02-24)
Lord, GM  (2026-02-26)
Created
May, B  (2025-12-27)
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