Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits

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R-HSA-997272
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Homo sapiens
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GABA B receptors are coupled to Gproteins and function by increasing the K+ and decreasing the Ca2+ inside the cell. The increase in K+ increases the negative membrane potential of the cell thereby hyper polarizing the cell which inhibits the release of neurotransmitters. The decrease in Ca2+ also inhibits neurotransmitter in two ways; first by preventing the fusion of synaptic vesicles containing the neurotransmitter with the plasma membrane and second by decreasing the Ca2+ dependent recruitment of synaptic vesicles to the plasma membrane. In particular GABA B receptors inhibit voltage gated Ca2+ channels via the activity of Gbeta/Ggamma subunits of G proteins.

Literature References
PubMed ID Title Journal Year
20655481 GABAB receptor coupling to G-proteins and ion channels

Slesinger, PA, Padgett, CL

Adv Pharmacol 2010
20655490 GABAB-GIRK2-mediated signaling in Down syndrome

Cramer, NP, Siarey, RJ, Stoffel, M, Galdzicki, Z, Best, TK

Adv Pharmacol 2010
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