Reactome | Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits

Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits

Stable Identifier

R-HSA-997272

Type

Pathway

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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Neuronal System (Homo sapiens)

- Transmission across Chemical Synapses (Homo sapiens)
  - Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
    - GABA receptor activation (Homo sapiens)
      - GABA B receptor activation (Homo sapiens)
        
        Activation of GABAB receptors (Homo sapiens)
        
        Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits (Homo sapiens)

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Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits

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GABA B receptors are coupled to Gproteins and function by increasing the K+ and decreasing the Ca2+ inside the cell. The increase in K+ increases the negative membrane potential of the cell thereby hyper polarizing the cell which inhibits the release of neurotransmitters. The decrease in Ca2+ also inhibits neurotransmitter in two ways; first by preventing the fusion of synaptic vesicles containing the neurotransmitter with the plasma membrane and second by decreasing the Ca2+ dependent recruitment of synaptic vesicles to the plasma membrane. In particular GABA B receptors inhibit voltage gated Ca2+ channels via the activity of Gbeta/Ggamma subunits of G proteins.

Literature References

PubMed ID	Title	Journal	Year
20655481	GABAB receptor coupling to G-proteins and ion channels Slesinger, PA, Padgett, CL	Adv Pharmacol	2010
20655490	GABAB-GIRK2-mediated signaling in Down syndrome Cramer, NP, Siarey, RJ, Stoffel, M, Galdzicki, Z, Best, TK	Adv Pharmacol	2010