Activation of GIRK/Kir3 Channels

Stable Identifier
R-HSA-1013020
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, extracellular region, plasma membrane
ReviewStatus
5/5
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Activation of GIRK/Kir3 Channels
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Binding of G beta gamma activates the GIRK/Kir3 channels that allow the efflux of K+ out of the cell resulting in a hyperpolarized membrane potential. This negative membrane potential prevents the activation of voltage dependent Ca2+ channels.
Literature References
PubMed ID Title Journal Year
17185339 Evidence for association of GABA(B) receptors with Kir3 channels and regulators of G protein signalling (RGS4) proteins

Fowler, CE, Aryal, P, Suen, KF, Slesinger, PA

J Physiol 2007
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Output
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as an event of
Catalyst Activity

G-protein activated inward rectifier potassium channel activity of GABA B receptor G-protein beta-gamma and Kir3 channel complex [plasma membrane]

Physical Entity
GABA B receptor G-protein beta-gamma and Kir3 channel complex [plasma membrane] (Homo sapiens)
Activity
G-protein activated inward rectifier potassium channel activity (GO:0015467)
Orthologous Events
Activation of GIRK/Kir3 Channels (Bos taurus)
Activation of GIRK/Kir3 Channels (Caenorhabditis elegans)
Activation of GIRK/Kir3 Channels (Canis familiaris)
Activation of GIRK/Kir3 Channels (Drosophila melanogaster)
Activation of GIRK/Kir3 Channels (Gallus gallus)
Activation of GIRK/Kir3 Channels (Mus musculus)
Activation of GIRK/Kir3 Channels (Rattus norvegicus)
Activation of GIRK/Kir3 Channels (Sus scrofa)
Activation of GIRK/Kir3 Channels (Xenopus tropicalis)
Cross References
Rhea
Authored
Mahajan, SS  (2010-11-12)
Reviewed
Restituito, S  (2008-11-27)
Created
Mahajan, SS  (2010-11-12)
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