Activation of GIRK/Kir3 Channels

Stable Identifier
R-HSA-1013020
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Binding of G beta gamma activates the GIRK/Kir3 channels that allow the efflux of K+ out of the cell resulting in a hyperpolarized membrane potential. This negative membrane potential prevents the activation of voltage dependent Ca2+ channels.

Literature References
PubMed ID Title Journal Year
17185339 Evidence for association of GABA(B) receptors with Kir3 channels and regulators of G protein signalling (RGS4) proteins

Fowler, CE, Aryal, P, Suen, KF, Slesinger, PA

J Physiol 2007
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
G-protein activated inward rectifier potassium channel activity of GABA B receptor G-protein beta-gamma and Kir3 channel complex [plasma membrane]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created