Activation of GIRK/Kir3 Channels

Stable Identifier
R-HSA-1013020
Type
Reaction
Species
Homo sapiens
Compartment
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Binding of G beta gamma activates the GIRK/Kir3 channels that allow the efflux of K+ out of the cell resulting in a hyperpolarized membrane potential. This negative membrane potential prevents the activation of voltage dependent Ca2+ channels.

Literature References
PubMed ID Title Journal Year
17185339 Evidence for association of GABA(B) receptors with Kir3 channels and regulators of G protein signalling (RGS4) proteins

Slesinger, PA, Fowler, CE, Suen, KF, Aryal, P

J Physiol 2007
Participants
Input
Participates
Catalyst Activity

G-protein activated inward rectifier potassium channel activity of GABA B receptor G-protein beta-gamma and Kir3 channel complex [plasma membrane]

Orthologous Events
Cross References
Rhea
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