Reactome | Activation of GIRK/Kir3 Channels

Activation of GIRK/Kir3 Channels

Stable Identifier

R-HSA-1013020

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, extracellular region, plasma membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

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Neuronal System (Homo sapiens)

- Potassium Channels (Homo sapiens)
  - Inwardly rectifying K+ channels (Homo sapiens)
    - G protein gated Potassium channels (Homo sapiens)
      - Activation of G protein gated Potassium channels (Homo sapiens)
        
        Activation of GIRK/Kir3 Channels (Homo sapiens)
- Transmission across Chemical Synapses (Homo sapiens)
  - Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
    - GABA receptor activation (Homo sapiens)
      - GABA B receptor activation (Homo sapiens)
        
        Activation of GABAB receptors (Homo sapiens)
        
        Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits (Homo sapiens)
        
        Activation of GIRK/Kir3 Channels (Homo sapiens)

General

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Binding of G beta gamma activates the GIRK/Kir3 channels that allow the efflux of K+ out of the cell resulting in a hyperpolarized membrane potential. This negative membrane potential prevents the activation of voltage dependent Ca2+ channels.

Literature References

PubMed ID	Title	Journal	Year
17185339	Evidence for association of GABA(B) receptors with Kir3 channels and regulators of G protein signalling (RGS4) proteins Slesinger, PA, Fowler, CE, Suen, KF, Aryal, P	J Physiol	2007