Association of GABA B receptor with G protein beta-gamma subunits

Stable Identifier
R-HSA-1013013
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane, extracellular region
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Association of GABA B receptor with G protein beta-gamma subunits
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Activation of GABA B receptors by GABA stimulates Gi/o proteins releasing the G beta gamma subunit that binds to voltage dependent Ca2+ channels.
Literature References
PubMed ID Title Journal Year
20453851 Gbeta5 recruits R7 RGS proteins to GIRK channels to regulate the timing of neuronal inhibitory signaling

Xie, K, Allen, KL, Kourrich, S, Colón-Saez, J, Thomas, MJ, Wickman, K, Martemyanov, KA

Nat Neurosci 2010
Participants
Input
Output
Participates
as an event of
Catalyst Activity

G protein-coupled GABA receptor activity of GABBR1:GABBR2:GABA [plasma membrane]

Physical Entity
GABBR1:GABBR2:GABA [plasma membrane] (Homo sapiens)
Activity
G protein-coupled GABA receptor activity (GO:0004965)
Orthologous Events
Association of GABA B receptor with G protein beta-gamma subunits (Bos taurus)
Association of GABA B receptor with G protein beta-gamma subunits (Caenorhabditis elegans)
Association of GABA B receptor with G protein beta-gamma subunits (Canis familiaris)
Association of GABA B receptor with G protein beta-gamma subunits (Mus musculus)
Authored
Mahajan, SS  (2010-11-26)
Reviewed
Restituito, S  (2008-11-27)
Created
Mahajan, SS  (2010-11-12)
Cite Us!