Association of GABA B receptor with G protein beta-gamma subunits

Stable Identifier
R-HSA-1013013
Type
Reaction
Species
Homo sapiens
Compartment
plasma membrane, extracellular region
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Association of GABA B receptor with G protein beta-gamma subunits
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Activation of GABA B receptors by GABA stimulates Gi/o proteins releasing the G beta gamma subunit that binds to voltage dependent Ca2+ channels.

Literature References
PubMed ID Title Journal Year
20453851 Gbeta5 recruits R7 RGS proteins to GIRK channels to regulate the timing of neuronal inhibitory signaling

Wickman, K, Martemyanov, KA, Allen, KL, Kourrich, S, Xie, K, Colón-Saez, J, Thomas, MJ

Nat Neurosci 2010
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Catalyst Activity

G protein-coupled GABA receptor activity of GABBR1:GABBR2:GABA [plasma membrane]

Physical Entity
GABBR1:GABBR2:GABA [plasma membrane] (Homo sapiens)
Activity
G protein-coupled GABA receptor activity (GO:0004965)
Orthologous Events
Association of GABA B receptor with G protein beta-gamma subunits (Caenorhabditis elegans)
Association of GABA B receptor with G protein beta-gamma subunits (Canis familiaris)
Association of GABA B receptor with G protein beta-gamma subunits (Danio rerio)
Association of GABA B receptor with G protein beta-gamma subunits (Gallus gallus)
Association of GABA B receptor with G protein beta-gamma subunits (Mus musculus)
Association of GABA B receptor with G protein beta-gamma subunits (Sus scrofa)
Authored
Mahajan, SS  (2010-11-25)
Reviewed
Restituito, S  (2008-11-27)
Created
Mahajan, SS  (2010-11-11)
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